Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2a': Implications for pathological roles of CK2 in promoting cancer cell survival.

Oncotarget

Volumn 4, Issue 4, 2013, Pages 560-571

  Turowec, Jacob P ^a   Vilk, Greg ^a   Gabriel, Michelle ^a   Litchfield, David W ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

Caspase 3; Isozyme specific substrate; Protein kinase CK2

Indexed keywords

CASEIN KINASE II; CASEIN KINASE IIALPHA; CASEIN KINASE IIBETA; CASPASE 3; OKADAIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL NUCLEUS; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HELA CELL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION;

EID: 84879151614     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.948     Document Type: Article

References (53)

1. Litchfield DW. Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J. 2003; 369: 1-15.
2. Gietz RD, Graham KC, Litchfield DW. Interactions between the subunits of casein kinase II. J Biol Chem. 1995; 270: 13017-13021.
3. Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, Sherlock G, Lewicki J, Shedden K, Clarke MF. The prognostic role of a gene signature from tumorigenic breastcancer cells. N Engl J Med. 2007; 356: 217-226.
4. Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, Vogelstein B. A phosphatase associated with metastasis of colorectal cancer. Science. 2001; 294: 1343-1346.
5. Duncan JS, Litchfield DW. Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2. Biochim Biophys Acta. 2008; 1784: 33-47.
6. Landesman-Bollag E, Romieu-Mourez R, Song DH, Sonenshein GE, Cardiff RD, Seldin DC. Protein kinase CK2 in mammary gland tumorigenesis. Oncogene. 2001; 20: 3247-3257.
7. Seldin DC, Leder P. Casein kinase II alpha transgene induced murine lymphoma: relation to theileriosis in cattle. Science. 1995; 267: 894-897.
8. Cozza G, Pinna LA, Moro S. Protein kinase CK2 inhibitors: a patent review. Expert Opin Ther Pat. 2012; 22: 1081-1097.
9. Siddiqui-Jain A, Drygin D, Streiner N, Chua P, Pierre F, O'Brien SE, Bliesath J, Omori M, Huser N, Ho C, Proffitt C, Schwaebe MK, Ryckman DM, Rice WG, Anderes K. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010; 70: 10288-10298.
10. Deshiere A, Duchemin-Pelletier E, Spreux E, Ciais D, Combes F, Vandenbrouck Y, Coute Y, Mikaelian I, Giusiano S, Charpin C, Cochet C, Filhol O. Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction. Oncogene. 2012;.
11. Brown MS, Diallo OT, Hu M, Ehsanian R, Yang X, Arun P, Lu H, Korman V, Unger G, Ahmed K, Van Waes C, Chen Z. CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules. Clin Cancer Res. 2010; 16: 2295-2307.
12. Wirkner U, Voss H, Lichter P, Ansorge W, Pyerin W. The human gene (CSNK2A1) coding for the casein kinase II subunit alpha is located on chromosome 20 and contains tandemly arranged Alu repeats. Genomics. 1994; 19: 257-265.
13. Yang-Feng TL, Zheng K, Kopatz I, Naiman T, Canaani D. Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. Nucleic Acids Res. 1991; 19: 7125-7129.
14. Yang-Feng TL, Naiman T, Kopatz I, Eli D, Dafni N, Canaani D. Assignment of the human casein kinase II alpha' subunit gene (CSNK2A1) to chromosome 16p13.2-p13.3. Genomics. 1994; 19: 173.
15. Litchfield DW, Luscher B. Casein kinase II in signal transduction and cell cycle regulation. Mol Cell Biochem. 1993; 127-128: 187-199.
16. St-Denis NA, Bailey ML, Parker EL, Vilk G, Litchfield DW. Localization of phosphorylated CK2alpha to the mitotic spindle requires the peptidyl-prolyl isomerase Pin1. J Cell Sci. 2011; 124: 2341-2348.
17. Messenger MM, Saulnier RB, Gilchrist AD, Diamond P, Gorbsky GJ, Litchfield DW. Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylationdependent interactions. J Biol Chem. 2002; 277: 23054-23064.
18. Bosc DG, Graham KC, Saulnier RB, Zhang C, Prober D, Gietz RD, Litchfield DW. Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2. J Biol Chem. 2000; 275: 14295-14306.
19. Heriche JK, Lebrin F, Rabilloud T, Leroy D, Chambaz EM, Goldberg Y. Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alpha. Science. 1997; 276: 952-955.
20. Bischoff N, Olsen B, Raaf J, Bretner M, Issinger OG, Niefind K. Structure of the human protein kinase CK2 catalytic subunit CK2alpha' and interaction thermodynamics with the regulatory subunit CK2beta. J Mol Biol. 2011; 407: 1-12.
21. Meggio F, Boldyreff B, Marin O, Marchiori F, Perich JW, Issinger OG, Pinna LA. The effect of polylysine on caseinkinase-2 activity is influenced by both the structure of the protein/peptide substrates and the subunit composition of the enzyme. Eur J Biochem. 1992; 205: 939-945.
22. Bidwai AP, Reed JC, Glover CV. Phosphorylation of calmodulin by the catalytic subunit of casein kinase II is inhibited by the regulatory subunit. Arch Biochem Biophys. 1993; 300: 265-270.
23. Salvi M, Sarno S, Cesaro L, Nakamura H, Pinna LA. Extraordinary pleiotropy of protein kinase CK2 revealed by weblogo phosphoproteome analysis. Biochim Biophys Acta. 2009;.
24. Xu X, Toselli PA, Russell LD, Seldin DC. Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit. Nat Genet. 1999; 23: 118-121.
25. Vilk G, Saulnier RB, St Pierre R, Litchfield DW. Inducible expression of protein kinase CK2 in mammalian cells. Evidence for functional specialization of CK2 isoforms. J Biol Chem. 1999; 274: 14406-14414.
26. Desagher S, Osen-Sand A, Montessuit S, Magnenat E, Vilbois F, Hochmann A, Journot L, Antonsson B, Martinou JC. Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. Mol Cell. 2001; 8: 601-611.
27. Riman S, Rizkallah R, Kassardjian A, Alexander KE, Luscher B, Hurt MM. Phosphorylation of the transcription factor YY1 by CK2alpha prevents cleavage by caspase 7 during apoptosis. Mol Cell Biol. 2012; 32: 797-807.
28. Duncan JS, Turowec JP, Vilk G, Li SS, Gloor GB, Litchfield DW. Regulation of cell proliferation and survival: convergence of protein kinases and caspases. Biochim Biophys Acta. 2010; 1804: 505-510.
29. Duncan JS, Turowec JP, Duncan KE, Vilk G, Wu C, Luscher B, Li SS, Gloor GB, Litchfield DW. A Peptidebased target screen implicates the protein kinase CK2 in the global regulation of caspase signaling. Sci Signal. 2011; 4: ra30.
30. Martic S, Gabriel M, Turowec JP, Litchfield DW, Kraatz HB. Versatile strategy for biochemical, electrochemical and immunoarray detection of protein phosphorylations. J Am Chem Soc. 2012; 134: 17036-17045.
31. Litchfield DW. Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J. 2003; 369: 1-15.
32. Olsten ME, Weber JE, Litchfield DW. CK2 interacting proteins: emerging paradigms for CK2 regulation? Mol Cell Biochem. 2005; 274: 115-124.
33. Salvi M, Sarno S, Marin O, Meggio F, Itarte E, Pinna LA. Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits. FEBS Lett. 2006; 580: 3948-3952.
34. Shore LJ, Soler AP, Gilmour SK. Ornithine decarboxylase expression leads to translocation and activation of protein kinase CK2 in vivo. J Biol Chem. 1997; 272: 12536-12543.
35. Lawson K, Larentowicz L, Laury-Kleintop L, Gilmour SK. B23 is a downstream target of polyamine-modulated CK2. Mol Cell Biochem. 2005; 274: 103-114.
36. Lawson K, Larentowicz L, Artim S, Hayes CS, Gilmour SK. A novel protein kinase CK2 substrate indicates CK2 is not directly stimulated by polyamines in vivo. Biochemistry. 2006; 45: 1499-1510.
37. Filhol O, Nueda A, Martel V, Gerber-Scokaert D, Benitez MJ, Souchier C, Saoudi Y, Cochet C. Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits. Mol Cell Biol. 2003; 23: 975-987.
38. Quadroni M, James P, Carafoli E. Isolation of phosphorylated calmodulin from rat liver and identification of the in vivo phosphorylation sites. J Biol Chem. 1994; 269: 16116-16122.
39. Orlandini M, Semplici F, Ferruzzi R, Meggio F, Pinna LA, Oliviero S. Protein kinase CK2alpha' is induced by serum as a delayed early gene and cooperates with Ha-ras in fibroblast transformation. J Biol Chem. 1998; 273: 21291-21297.
40. Li X, Guan B, Maghami S, Bieberich CJ. NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells. Mol Cell Biol. 2006; 26: 3008-3017.
41. Olsten ME, Canton DA, Zhang C, Walton PA, Litchfield DW. The Pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane. J Biol Chem. 2004; 279: 42114-42127.
42. Gnad F, Gunawardena J, Mann M. PHOSIDA 2011: the posttranslational modification database. Nucleic Acids Res. 2011; 39: D253-60.
43. Mimnaugh EG, Worland PJ, Whitesell L, Neckers LM. Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase. J Biol Chem. 1995; 270: 28654-28659.
44. Shi Y, Brown ED, Walsh CT. Expression of recombinant human casein kinase II and recombinant heat shock protein 90 in Escherichia coli and characterization of their interactions. Proc Natl Acad Sci U S A. 1994; 91: 2767-2771.
45. Miyata Y, Yahara I. Interaction between casein kinase II and the 90-kDa stress protein, HSP90. Biochemistry. 1995; 34: 8123-8129.
46. Pinna LA, Meggio F. Protein kinase CK2 ("casein kinase-2") and its implication in cell division and proliferation. Prog Cell Cycle Res. 1997; 3: 77-97.
47. Cochet C, Chambaz EM. Oligomeric structure and catalytic activity of G type casein kinase. Isolation of the two subunits and renaturation experiments. J Biol Chem. 1983; 258: 1403-1406.
48. Luscher B, Litchfield DW. Biosynthesis of casein kinase II in lymphoid cell lines. Eur J Biochem. 1994; 220: 521-526.
49. Guerra B, Siemer S, Boldyreff B, Issinger OG. Protein kinase CK2: evidence for a protein kinase CK2beta subunit fraction, devoid of the catalytic CK2alpha subunit, in mouse brain and testicles. FEBS Lett. 1999; 462: 353-357.
50. Jordan M, Schallhorn A, Wurm FM. Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res. 1996; 24: 596-601.
51. Penner CG, Wang Z, Litchfield DW. Expression and localization of epitope-tagged protein kinase CK2. J Cell Biochem. 1997; 64: 525-537.
52. Vilk G, Derksen DR, Litchfield DW. Inducible expression of the regulatory protein kinase CK2beta subunit: incorporation into complexes with catalytic CK2 subunits and re-examination of the effects of CK2beta on cell proliferation. J Cell Biochem. 2001; 84: 84-99.
53. Turowec JP, Duncan JS, French AC, Gyenis L, St Denis NA, Vilk G, Litchfield DW. Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells. Methods Enzymol. 2010; 484: 471-493.