Epidermal growth factor receptor tyrosine kinase inhibition up-regulates interleukin-6 in cancer cells and induces subsequent development of interstitial pneumonia

Oncotarget

Volumn 4, Issue 4, 2013, Pages 550-559

  Ishiguro, Yukari ^a,b   Ishiguro, Hitoshi ^a,b   Miyamoto, Hiroshi ^b  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Cytokine; EGFR TKI; Fibrosis; IL 6; Side effect

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ALPHA ACTIN; COLLAGEN; COLLAGEN TYPE 1A1; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEFITINIB; INTERLEUKIN 6; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER PATIENT; CELL ASSAY; CELL STRAIN A549; CELL STRAIN HSC 3; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; INTERSTITIAL PNEUMONIA; LUNG CANCER; LUNG FIBROBLAST; LUNG FIBROSIS; PATHOGENESIS; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RISK REDUCTION; SIGNAL TRANSDUCTION; TONGUE CANCER; UPREGULATION; WESTERN BLOTTING;

EID: 84879137528     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.939     Document Type: Article

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