Cost of a quality-adjusted life year in liver transplantation: The influence of the indication and the Model for End-Stage Liver Disease score

Liver Transplantation

Volumn 17, Issue 11, 2011, Pages 1333-1343

  Åberg, Fredrik ^a   Mäklin, Suvi ^b   Räsänen, Pirjo ^b,c   Roine, Risto P ^c   Sintonen, Harri ^d   Koivusalo, Anna Maria ^a   Höckerstedt, Krister ^a   Isoniemi, Helena ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c HOSPITAL DISTRICT OF HELSINKI AND UUSIMAA   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LIVER FAILURE; ADULT; ARTICLE; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; END STAGE LIVER DISEASE; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUALITY ADJUSTED LIFE YEAR;

ADULT; CHOLANGITIS, SCLEROSING; COST-BENEFIT ANALYSIS; DRUG COSTS; FEMALE; FINLAND; HEALTH CARE COSTS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIVER CIRRHOSIS, BILIARY; LIVER DISEASES, ALCOHOLIC; LIVER FAILURE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MODELS, STATISTICAL; QUALITY OF LIFE; QUALITY-ADJUSTED LIFE YEARS;

EID: 82955197321     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.22388     Document Type: Article

References (45)

1. Abecassis M. Making dollars and sense out of liver transplantation. Liver Transpl 2009;15:1159-1161.
2. Bambha K, Kim WR. Liver transplantation is effective, but is it cost-effective? Liver Transpl 2003;9:1308-1311. (Pubitemid 37536802)
3. van der Hilst CS, Ijtsma AJ, Slooff MJ, Tenvergert EM. Cost of liver transplantation: a systematic review and meta-analysis comparing the United States with other OECD countries. Med Care Res Rev 2009;66:3-22.
4. Biancofiore G. Economics and organ transplantation: a challenge to win. Minerva Anestesiol 2007;73:487-488. (Pubitemid 350055246)
5. O'Grady JG. Clinical economics review: liver transplantation. Aliment Pharmacol Ther 1997;11:445-451. (Pubitemid 27286943)
6. Showstack J, Katz PP, Lake JR, Brown RS Jr, Dudley RA, Belle S, et al. Resource utilization in liver transplantation: effects of patient characteristics and clinical practice. NIDDK Liver Transplantation Database Group. JAMA 1999;281:1381-1386. (Pubitemid 29190215)
7. Russell PS. Understanding resource use in liver transplantation. JAMA 1999;281:1431-1432. (Pubitemid 29190222)
8. Rawlins MD, Culyer AJ. National Institute for Clinical Excellence and its value judgments. BMJ 2004;329:224-227. (Pubitemid 39013284)
9. Longworth L, Young T, Buxton MJ, Ratcliffe J, Neuberger J, Burroughs A, Bryan S; for CELT Project Team. Midterm cost-effectiveness of the liver transplantation program of England and Wales for three disease groups. Liver Transpl 2003;9:1295-1307. (Pubitemid 37536801)
10. Sagmeister M, Mullhaupt B, Kadry Z, Kullak-Ublick GA, Clavien PA, Renner EL. Cost-effectiveness of cadaveric and living-donor liver transplantation. Transplantation 2002;73:616-622. (Pubitemid 34193627)
11. Ouwens JP, van Enckevort PJ, TenVergert EM, Bonsel GJ, van der Bij W, Haagsma EB, et al. The cost effectiveness of lung transplantation compared with that of heart and liver transplantation in the Netherlands. Transpl Int 2003;16:123-127. (Pubitemid 36682208)
12. Axelrod DA, Koffron AJ, Baker T, Al-Saden P, Dixler I, McNatt G, et al. The economic impact of MELD on liver transplant centers. Am J Transplant 2005;5:2297-2301. (Pubitemid 41648479)
13. Ammori JB, Pelletier SJ, Lynch R, Cohn J, Ads Y, Campbell DA, Englesbe MJ. Incremental costs of post-liver transplantation complications. J Am Coll Surg 2008;206:89-95. (Pubitemid 350267243)
14. Washburn WK, Pollock BH, Nichols L, Speeg KV, Halff G. Impact of recipient MELD score on resource utilization. Am J Transplant 2006;6:2449-2454. (Pubitemid 44359433)
15. Earl TM, Cooil B, Rubin JE, Chari RS. Cost prediction in liver transplantation using pretransplant donor and recipient characteristics. Transplantation 2008;86: 238-244.
16. Taylor MC, Greig PD, Detsky AS, McLeod RS, Abdoh A, Krahn MD. Factors associated with the high cost of liver transplantation in adults. Can J Surg 2002;45:425-434. (Pubitemid 36133657)
17. van Agthoven M, Metselaar HJ, Tilanus HW, de Man RA, IJzermans JN, Martin van Ineveld BM. A comparison of the costs and effects of liver transplantation for acute and for chronic liver failure. Transpl Int 2001;14:87-94. (Pubitemid 32405445)
18. Filipponi F, Pisati R, Cavicchini G, Ulivieri MI, Ferrara R, Mosca F. Cost and outcome analysis and cost determinants of liver transplantation in a European National Health Service hospital. Transplantation 2003;75: 1731-1736. (Pubitemid 36629158)
19. Buchanan P, Dzebisashvili N, Lentine KL, Axelrod DA, Schnitzler MA, Salvalaggio PR. Liver transplantation cost in the Model for End-Stage Liver Disease era: looking beyond the transplant admission. Liver Transpl 2009;15: 1270-1277.
20. Best JH, Veenstra DL, Geppert J. Trends in expenditures for Medicare liver transplant recipients. Liver Transpl 2001;7:858-862. (Pubitemid 33040459)
21. Finlex. Sosiaali- ja terveysministeriön asetus. http://www.finlex. fi/fi/laki/alkup/2009/20090201. Accessed July 2011.
22. Sintonen H. 15D instrument. http://www.15d-instru-ment.net/15d. Accessed July 2011.
23. Sintonen H. The 15-D measure of health related quality of life. II Feasibility, reliability and validity of its valuation system. http://www.buseco.monash.edu.au/centres/che/pubs/wp42.pdf. Accessed July 2011.
24. Sintonen H. The 15D instrument of health-related quality of life: properties and applications. Ann Med 2001;33:328-336. (Pubitemid 32675373)
25. Stavem K. Reliability, validity and responsiveness of two multiattribute utility measures in patients with chronic obstructive pulmonary disease. Qual Life Res 1999;8:45-54. (Pubitemid 29362745)
26. Hawthorne G, Richardson J, Day NA. A comparison of the assessment of quality of life (AQoL) with four other generic utility instruments. Ann Med 2001;33:358-370. (Pubitemid 32675377)
27. Moock J, Kohlmann T. Comparing preference-based qual-ity-of-life measures: results from rehabilitation patients with musculoskeletal, cardiovascular, or psychosomatic disorders. Qual Life Res 2008;17:485-495.
28. Aberg F, Rissanen AM, Sintonen H, Roine RP, Höcker-stedt K, Isoniemi H. Health-related quality of life and employment status of liver transplant patients. Liver Transpl 2009;15:64-72.
29. Cookson R, McCabe C, Tsuchiya A. Public healthcare resource allocation and the rule of rescue. J Med Ethics 2008;34:540-544.
30. McKie J, Richardson J. The rule of rescue. Soc Sci Med 2003;56:2407-2419. (Pubitemid 36555359)
31. Ratcliffe J, Buxton M, Young T, Longworth L. Determining priority for liver transplantation: a comparison of cost per QALY and discrete choice experiment-generated public preferences. Appl Health Econ Health Policy 2005;4:249-255. (Pubitemid 43242213)
32. Volk ML, Lok AS, Ubel PA, Vijan S. Beyond utilitarianism: a method for analyzing competing ethical principles in a decision analysis of liver transplantation. Med Decis Making 2008;28:763-772.
33. Azoulay D, Linhares MM, Huguet E, Delvart V, Castaing D, Adam R, et al. Decision for retransplantation of the liver: an experience- and cost-based analysis. Ann Surg 2002;236:713-721. (Pubitemid 35403226)
34. Kremers WK, van IJperen M, Kim WR, Freeman RB, Harper AM, Kamath PS, Wiesner RH. MELD score as a predictor of pretransplant and posttransplant survival in OPTN/UNOS status 1 patients. Hepatology 2004;39:764-769. (Pubitemid 38337656)
35. Katoonizadeh A, Decaestecker J, Wilmer A, Aerts R, Ver-slype C, Vansteenbergen W, et al. MELD score to predict outcome in adult patients with non-acetaminophen-induced acute liver failure. Liver Int 2007;27:329-334. (Pubitemid 46416622)
36. Schmidt LE, Larsen FS. MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury. Hepatology 2007;45:789-796. (Pubitemid 46450630)
37. Al Sibae MR, Cappell MS. Accuracy of MELD scores in predicting mortality in decompensated cirrhosis from variceal bleeding, hepatorenal syndrome, alcoholic hepatitis, or acute liver failure as well as mortality after non-transplant surgery or TIPS. Dig Dis Sci 2011;56: 977-987.
38. Yantorno SE, Kremers WK, Ruf AE, Trentadue JJ, Podestá LG, Villamil FG. MELD is superior to King's College and Clichy's criteria to assess prognosis in fulminant hepatic failure. Liver Transpl 2007;13: 822-828. (Pubitemid 46939436)
39. Schaubel DE, Guidinger MK, Biggins SW, Kalbfleisch JD, Pomfret EA, Sharma P, Merion RM. Survival benefit-based deceased-donor liver allocation. Am J Transplant 2009;9(pt 2):970-981.
40. Merion RM, Schaubel DE, Dykstra DM, Freeman RB, Port FK, Wolfe RA. The survival benefit of liver transplantation. Am J Transplant 2005;5:307-313. (Pubitemid 40179517)
41. Foxton MR, Al-Freah MA, Portal AJ, Sizer E, Bernal W, Auzinger G, et al. Increased Model for End-Stage Liver Disease score at the time of liver transplant results in prolonged hospitalization and overall intensive care unit costs. Liver Transpl 2010;16:668-677.
42. Habib S, Berk B, Chang CC, Demetris AJ, Fontes P, Dvor-chik I, et al. MELD and prediction of post-liver transplantation survival. Liver Transpl 2006;12:440-447.
43. McGregor M. Cost-utility analysis: use QALYs only with great caution. CMAJ 2003;168:433-434. (Pubitemid 36255729)
44. Kantola T, Mäklin S, Koivusalo AM, Räsänen P, Rissanen A, Roine R, et al. Cost-utility of Molecular Adsorbent Recirculating System treatment in acute liver failure. World J Gastroenterol 2010;16:2227-2234.
45. Malmström RK, Roine RP, Heikkilä A, Räsänen P, Sinto-nen H, Muroma-Karttunen R, Honkanen E. Cost analysis and health-related quality of life of home and self-care satellite haemodialysis. Nephrol Dial Transplant 2008; 23:1990-1996. (Pubitemid 351768159)