Hippocampal neuron loss is correlated with cognitive deficits in SAMP8 mice

Neurological Sciences

Volumn 34, Issue 6, 2013, Pages 963-969

  Li, Guomin ^a,b   Cheng, Haiyan ^b,c   Zhang, Xuezhu ^b   Shang, Xuemei ^b   Xie, Hui ^a   Zhang, Xin ^b   Yu, Jianchun ^b   Han, Jingxian ^b  

^a THE FIRST PEOPLE S HOSPITAL OF CHENZHOU   (China)

^b FIRST TEACHING HOSPITAL OF TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c Department of Traditional Chinese Medicine   (China)

Author keywords

Morris water maze; Neuron loss; Senescence accelerated mice prone 8 (SAMP8); Stereology

Indexed keywords

AGING; ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL LOSS; COGNITIVE DEFECT; CONTROLLED STUDY; DEGENERATIVE DISEASE; DENTATE GYRUS; DISEASE SEVERITY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; LEARNING DISORDER; MEMORY DISORDER; MOUSE; NERVE CELL; NEUROFIBRILLARY TANGLE; NONHUMAN; SCORING SYSTEM; SENESCENCE ACCELERATED MOUSE;

AGING; ANALYSIS OF VARIANCE; ANIMALS; CELL COUNT; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MAZE LEARNING; MICE; MICE, INBRED STRAINS; NEURONS; STEREOTAXIC TECHNIQUES;

EID: 84879121976     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-012-1173-z     Document Type: Article

References (33)

1. Tiraboschi P, Hansen LA, Thal LJ, Corey-Bloom J (2004) The importance of neuritic plaques and tangles to the development and evolution of AD. Neurology 62(11):1984-1989
2. West MJ, Coleman PD, Flood DG, Janke AL, Rose SE, Semple J, Hong MS, Herman DH, Gravano D, Doddrell DM, Toga AW (1994) Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344:769-772
3. Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42:631-639
4. Samuel W, Terry RD, DeTeresa R, Butters N, Masliah E (1994) Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia. Arch Neurol 51:772-778
5. Bondareff W, Mountjoy CQ, Roth M (1982) Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia. Neurology 32:164-168
6. Bussiere T, Giannakopoulos P, Bouras C, Perl DP, Morrison JH, Hof PR (2003) Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9. J Comp Neurol 463:281-302
7. Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT (1997) Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 41:17-24
8. Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, Delon MR (1982) Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215:1237-1239
9. Chen Q, Nakajima A, Choi SH, Xiong X, Sisodia SS, Tang YP (2008) Adult neurogenesis is functionally associated with AD-like neurodegeneration. Neurobiol Dis 29:316-326
10. West MJ, Kawas CH, Stewart WF, Rudow GL, Troncoso JC (2004) Hippocampal neurons in pre-clinical Alzheimer's disease. Neurobiol Aging 25:1205-1212
11. Alvarez-García O, Vega-Naredo I, Sierra V, Caballero B, Tomás-Zapico C, Camins A, García JJ, Pallàs M, Coto-Montes A (2006) Elevated oxidative stress in the brain of senescence-accelerated mice at 5 months of age. Biogerontology 7:43-52
12. Canudas AM, Gutierrez-Cuesta J, Rodríguez MI, Acuña- Castroviejo D, Sureda FX, Camins A, Pallàs M (2005) Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM). Mech Ageing Dev 126:1300-1304
13. Morley JE, Kumar VB, Bernardo AE, Farr SA, Uezu K, Tumosa N, Flood JF (2000) Beta-amyloid precursor polypeptide in SAMP8 mice affects learning and memory. Peptides 21:1761-1767
14. Yamaguchi H, Ishiguro K, Uchida T, Takashima A, Lemere CA, Imahori K (1996) Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II. Acta Neuropathol 92:232-241
15. Takeda T, Hosokawa M, Takeshita S, Irino M, Higuchi K, Matsushita T, Tomita Y, Yasuhira K, Hamamoto H, Shimizu K, Ishii M, Yamamuro T (1981) A new murine model of accelerated senescence. Mech Ageing Dev 17:183-194
16. Hosokawa M, Kasai R, Higuchi K, Takeshita S, Shimizu K, Hamamoto H, Honma A, Irino M, Toda K, Matsumura A (1984) Grading score system: a method for evaluation of the degree of senescence in senescence accelerated mouse (SAM). Mech Ageing Dev 26:91-102
17. Kohno A, Yonezu T, Matsushita M, Higuchi K, Higuchi K, Takeshita S, Hosokawa M, Takeda T (1985) Chronic food restriction modulates the advance of senescence in the senescence accelerated mouse (SAM). J Nutr 115:1259-1266
18. Liu CZ, Yu JC, Cheng HY, Li T, Zhang XZ, Zhang LL, Han JX (2006) Spatial memory performance and hippocampal neuron number in osteoporotic SAMP6 mice. Exp Neurol 201:452-460
19. Yu J, Liu C, Zhang X, Han J (2005) Acupuncture improved cognitive impairment caused by multi-infarct dementia in rats. Physiol Behav 86:434-441
20. West MJ, Slomianka L, Gundersen HJ (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231:482-497
21. Hausdorf J, Lemmens MA, Kaplan S, Marangoz C, Milz S, Odaci E, Korr H, Schmitz C, Maier M (2008) Extracorporeal shockwave application to the distal femur of rabbits diminishes the number of neurons immunoreactive for substance P in dorsal root ganglia L5. Brain Res 1207:96-101
22. Gundersen HJ, Jensen EB (1987) The efficacy of systematic sampling in stereology and its prediction. J Microsc 147:229-263
23. von Gunten A, Kövari E, Bussière T, Rivara CB, Gold G, Bouras C, Hof PR, Giannakopoulos P (2006) Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease. Neurobiol Aging 27:270-277
24. Barber R, McKeith IG, Ballard C, Gholkar A, O'Brien JT (2001) A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: magnetic resonance imaging volumetric study. Dement Geriatr Cogn Disord 12:198-205
25. Thompson PM, Hayashi KM, De Zubicaray GI et al (2004) Mapping hippocampal and ventricular change in Alzheimer disease. Neuroimage 22:1754-1766
26. Price JL, Ko AI, Wade MJ, Tsou SK, McKeel DW, Morris JC (2001) Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Arch Neurol 58:1395-1402
27. Casas C, Sergeant N, Itier JM, Blanchard V, Wirths O, van der Kolk N, Vingtdeux V, van de Steeg E, Ret G, Canton T, Drobecq H, Clark A, Bonici B, Delacourte A, Benavides J, Schmitz C, Tremp G, Bayer TA, Benoit P, Pradier L (2004) Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol 165:1289-1300
28. Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L (1999) Plaque-independent disruption of neural circuits in Alzheimer'sdisease mouse models. Proc Natl Acad Sci USA 96:3228-3233
29. Schmitz C, Rutten BP, Pielen A, Schäfer S, Wirths O, Tremp G, Czech C, Blanchard V, Multhaup G, Rezaie P, Korr H, Steinbusch HW, Pradier L, Bayer TA (2004) Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am J Pathol 164:1495-1502
30. Bonthius DJ, McKim R, Koele L, Harb H, Karacay B, Mahoney J, Pantazis NJ (2004) Use of frozen sections to determine neuronal number in the murine hippocampus and neocortex using the optical disector and optical fractionator. Brain Res Protoc 14:45-57
31. Duyckaerts C, Potier MC, Delatour B (2008) Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol 115:5-38
32. Zhu X, Raina AK, Perry G, Smith MA (2004) Alzheimer's disease: the two-hit hypothesis. Lancet Neurol 3:219-226
33. Zhu X, Lee HG, Perry G, Smith MA (2007) Alzheimer disease, the two-hit hypothesis: an update. Biochim Biophys Acta 1772:494-502 of Higher Education