A randomized trial of adenotonsillectomy for childhood sleep apnea

New England Journal of Medicine

Volumn 368, Issue 25, 2013, Pages 2366-2376

  Marcus, Carole L ^a   Moore, Reneé H ^a,b   Rosen, Carol L ^c   Giordani, Bruno ^d   Garetz, Susan L ^d   Taylor, H Gerry ^c   Mitchell, Ron B ^e,f   Amin, Raouf ^g   Katz, Eliot S ^h   Arens, Raanan ^j   Paruthi, Shalini ^e   Muzumdar, Hiren ^j   Gozal, David ^k   Thomas, Nina Hattiangadi ^a   Janice Ware, Dean Beebe ^g,h   Snyder, Karen ^e   Elden, Lisa ^a   Sprecher, Robert C ^c   Willging, Paul ^g   Jones, Dwight ^h   Bent, John P ^j   Hoban, Timothy ^d   Chervin, Ronald D ^d   Ellenberg, Susan S ^a   Redline, Susan ⁱ   more..

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^g CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^h BOSTON CHILDREN S HOSPITAL   (United States)

ⁱ BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^j ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^k UNIVERSITY OF CHICAGO   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADENOTONSILLECTOMY; ARTICLE; ATTENTION; CHILD; CHILD BEHAVIOR; CONTROLLED STUDY; EXECUTIVE FUNCTION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; POLYSOMNOGRAPHY; PRESCHOOL CHILD; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SINGLE BLIND PROCEDURE; SLEEP DISORDERED BREATHING; TREATMENT OUTCOME; WATCHFUL WAITING;

EID: 84879121091     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1215881     Document Type: Article

References (40)

1. Marcus CL, Brooks LJ, Draper KA, et al. Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics 2012;130:576-84.
2. Bhattacharyya N, Lin HW. Changes and consistencies in the epidemiology of pediatric adenotonsillar surgery, 1996-2006. Otolaryngol Head Neck Surg 2010;143:680-4.
3. Row BW, Kheirandish L, Neville JJ, Gozal D. Impaired spatial learning and hyperactivity in developing rats exposed to intermittent hypoxia. Pediatr Res 2002;52:449-53. (Pubitemid 34920280)
4. Redline S, Tishler PV, Schluchter M, Aylor J, Clark K, Graham G. Risk factors for sleep-disordered breathing in children: associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med 1999;159:1527-32. (Pubitemid 29227864)
5. Mitchell RB, Kelly J. Outcome of adenotonsillectomy for obstructive sleep apnea in obese and normal-weight children. Otolaryngol Head Neck Surg 2007;137:43-8. (Pubitemid 46962164)
6. Redline S, Amin R, Beebe D, et al. The Childhood Adenotonsillectomy Trial (CHAT): rationale, design, and challenges of a randomized controlled trial evaluating a standard surgical procedure in a pediatric population. Sleep 2011;34:1509-17.
7. Marcus CL, Omlin KJ, Basinki DJ, et al. Normal polysomnographic values for children and adolescents. Am Rev Respir Dis 1992;146:1235-9.
8. Witmans MB, Keens TG, Davidson Ward SL, Marcus CL. Obstructive hypopneas in children and adolescents: normal values. Am J Respir Crit Care Med 2003;168:1540. (Pubitemid 38037344)
9. Uliel S, Tauman R, Greenfeld M, Sivan Y. Normal polysomnographic respiratory values in children and adolescents. Chest 2004;125:872-8. (Pubitemid 38367276)
10. Montgomery-Downs HE, O'Brien LM, Gulliver TE, Gozal D. Polysomnographic characteristics in normal preschool and early school-aged children. Pediatrics 2006;117:741-53. (Pubitemid 46063216)
11. Korkman N, Kirk U, Kemp S. NEPSY: a developmental neuropsychological assessment manual. New York: Psychological Corporation, 1998.
12. Conners CK. Conners Rating Scales - Revised Technical Manual. 5th ed. North Tonawanda, NY: Multi-Health Systems, 2001.
13. Gioia GA, Isquith PK, Guy PK, Kenworthy L. Behavior Rating Inventory of Executive Function (BRIEF). Odessa, FL: Psychological Assessment Resources, 2000.
14. Chervin RD, Hedger K, Dillon JE, Pituch KJ. Pediatric Sleep Questionnaire (PSQ): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems. Sleep Med 2000;1:21-32.
15. Melendres MC, Lutz JM, Rubin ED, Marcus CL. Daytime sleepiness and hyperactivity in children with suspected sleep-disordered breathing. Pediatrics 2004;114:768-75. (Pubitemid 41529537)
16. Varni JW, Seid M, Kurtin PS. PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care 2001;39:800-12. (Pubitemid 33686263)
17. Franco RA Jr, Rosenfeld RM, Rao M. First place - resident clinical science award 1999: quality of life for children with obstructive sleep apnea. Otolaryngol Head Neck Surg 2000;123:9-16. (Pubitemid 30461178)
18. Elliott CD. Differential abilities scale: introductory and technical handbook. San Antonio: Harcourt Brace Jovanovich, 1990.
19. Gottlieb DJ, Chase C, Vezina RM, et al. Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old children. J Pediatr 2004;145:458-64. (Pubitemid 39345980)
20. PROC MI, version 9.3. Cary, NC: SAS Institute. 2011.
21. Varni JW, Burwinkle TM, Seid M, Skarr D. The PedsQL 4.0 as a pediatric population health measure: feasibility, reliability, and validity. Ambul Pediatr 2003;3:329-41. (Pubitemid 37527280)
22. Brouillette RT, Fernbach SK, Hunt CE. Obstructive sleep apnea in infants and children. J Pediatr 1982;100:31-40. (Pubitemid 12209612)
23. Guilleminault C, Korobkin R, Winkle R. A review of 50 children with obstructive sleep apnea syndrome. Lung 1981;159:275-87. (Pubitemid 11014647)
24. Gozal D. Sleep-disordered breathing and school performance in children. Pediatrics 1998;102:616-20. (Pubitemid 28409262)
25. Chervin RD, Ruzicka DL, Giordani BJ, et al. Sleep-disordered breathing, behavior, and cognition in children before and after adenotonsillectomy. Pediatrics 2006;117(4):e769-e778. (Pubitemid 46071482)
26. Montgomery-Downs HE, Crabtree VM, Gozal D. Cognition, sleep and respiration in at-risk children treated for obstructive sleep apnoea. Eur Respir J 2005;25:336-42. (Pubitemid 40246536)
27. O'Brien LM, Mervis CB, Holbrook CR, et al. Neurobehavioral correlates of sleep-disordered breathing in children. J Sleep Res 2004;13:165-72. (Pubitemid 38829898)
28. Friedman BC, Hendeles-Amitai A, Kozminsky E, et al. Adenotonsillectomy improves neurocognitive function in children with obstructive sleep apnea syndrome. Sleep 2003;26:999-1005. (Pubitemid 39619761)
29. Kohler MJ, Lushington K, van den Heuvel CJ, Martin J, Pamula Y, Kennedy D. Adenotonsillectomy and neurocognitive deficits in children with sleep disordered breathing. PLoS One 2009;4(10):e7343.
30. Halbower AC, Degaonkar M, Barker PB, et al. Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury. PLoS Med 2006;3(8):e301.
31. O'Brien LM, Mervis CB, Holbrook CR, et al. Neurobehavioral implications of habitual snoring in children. Pediatrics 2004;114:44-9. (Pubitemid 38857564)
32. Cortese S, Faraone SV, Konofal E, Lecendreux M. Sleep in children with attention-deficit/hyperactivity disorder: meta-analysis of subjective and objective studies. J Am Acad Child Adolesc Psychiatry 2009;48:894-908.
33. Emancipator JL, Storfer-Isser A, Taylor HG, et al. Variation of cognition and achievement with sleep-disordered breathing in full-term and preterm children. Arch Pediatr Adolesc Med 2006;160:203-10. (Pubitemid 43213869)
34. Apostolidou MT, Alexopoulos EI, Chaidas K, et al. Obesity and persisting sleep apnea after adenotonsillectomy in Greek children. Chest 2008;134:1149-55.
35. Brietzke SE, Gallagher D. The effectiveness of tonsillectomy and adenoidectomy in the treatment of pediatric obstructive sleep apnea/hypopnea syndrome: a meta-analysis. Otolaryngol Head Neck Surg 2006;134:979-84. (Pubitemid 43766558)
36. Bhattacharjee R, Kheirandish-Gozal L, Spruyt K, et al. Adenotonsillectomy outcomes in treatment of obstructive sleep apnea in children: a multicenter retrospective study. Am J Respir Crit Care Med 2010;182:676-83.
37. Tauman R, Gulliver TE, Krishna J, et al. Persistence of obstructive sleep apnea syndrome in children after adenotonsillectomy. J Pediatr 2006;149:803-8. (Pubitemid 44809273)
38. Costa DJ, Mitchell R. Adenotonsillectomy for obstructive sleep apnea in obese children: a meta-analysis. Otolaryngol Head Neck Surg 2009;140:455-60.
39. Mitchell RB, Kelly J. Adenotonsillectomy for obstructive sleep apnea in obese children. Otolaryngol Head Neck Surg 2004;131:104-8. (Pubitemid 38902772)
40. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum, 1988.