Mitochondrial calcium uniporter, MiRNA and cancer

Communicative and Integrative Biology

Volumn 6, Issue 3, 2013, Pages

  Marchi, Saverio ^a   Pinton, Paolo ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

Apoptosis; Calcium(Ca2+); Cancer; Cell death; MicroRNAs (MiRNA); Mitochondria; Mitochondrial CalciumUniporter (MCU)

Indexed keywords

EID: 84879114425     PISSN: 19420889     EISSN: 19420889     Source Type: Journal    
DOI: 10.4161/cib.23818     Document Type: Article

References (23)

1. Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 2011; 476:341-5; PMID:21685886; http://dx.doi. org/10.1038/nature10234.
2. De Stefani D, Raffaello A, Teardo E, Szabò I, Rizzuto R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 2011; 476:336-40; PMID:21685888; http://dx.doi. org/10.1038/nature10230
3. Perocchi F, Gohil VM, Girgis HS, Bao XR, McCombs JE, Palmer AE, et al. MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature 2010; 467:291-6; PMID:20693986; http://dx.doi.org/10.1038/nature09358.
4. Mallilankaraman K, Cárdenas C, Doonan PJ, Chandramoorthy HC, Irrinki KM, Golenár T, et al. MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Nat Cell Biol 2012; 14:1336-43; PMID:23178883; http://dx.doi.org/10.1038/ncb2622.
5. Giorgi C, Agnoletto C, Bononi A, Bonora M, De Marchi E, Marchi S, et al. Mitochondrial calcium homeostasis as potential target for mitochondrial medicine. Mitochondrion 2012; 12:77- 85; PMID:21798374; http://dx.doi.org/10.1016/j. mito.2011.07.004.
6. Giorgi C, Baldassari F, Bononi A, Bonora M, De Marchi E, Marchi S, et al. Mitochondrial Ca(2+) and apoptosis. Cell Calcium 2012; 52:36-43; PMID:22480931; http://dx.doi.org/10.1016/j. ceca.2012.02.008.
7. + release and apoptosis. Cell Death Dis 2012; 3:e304; PMID:22552281; http://dx.doi.org/10.1038/cddis.2012.45.
8. Pinton P, Ferrari D, Magalhães P, Schulze-Osthoff K, Di Virgilio F, Pozzan T, et al. Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells. J Cell Biol 2000; 148:857-62; PMID:10704437; http://dx.doi.org/10.1083/jcb.148.5.857.
9. Rimessi A, Marchi S, Fotino C, Romagnoli A, Huebner K, Croce CM, et al. Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis. Proc Natl Acad Sci USA 2009; 106:12753-8; PMID:19622739; http://dx.doi. org/10.1073/pnas.0906484106.
10. Giorgi C, Ito K, Lin HK, Santangelo C, Wieckowski MR, Lebiedzinska M, et al. PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science 2010; 330:1247-51; PMID:21030605; http://dx.doi.org/10.1126/science. 1189157.
11. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136:215-33; PMID:19167326; http://dx.doi.org/10.1016/j. cell.2009.01.002.
12. Iorio MV, Croce CM. MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 2012; 4:143-59; PMID:22351564; http://dx.doi. org/10.1002/emmm.201100209.
13. Birks DK, Barton VN, Donson AM, Handler MH, Vibhakar R, Foreman NK. Survey of MicroRNA expression in pediatric brain tumors. Pediatr Blood Cancer 2011; 56:211-6; PMID:21157891; http:// dx.doi.org/10.1002/pbc.22723.
14. Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, de Martino I, et al. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 2008; 13:272-86; PMID:18328430; http://dx.doi. org/10.1016/j.ccr.2008.02.013.
15. Dacic S, Kelly L, Shuai Y, Nikiforova MN. miRNA expression profiling of lung adenocarcinomas: correlation with mutational status. Mod Pathol 2010; 23:1577-82; PMID:20818338; http://dx.doi. org/10.1038/modpathol.2010.152.
16. Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, et al. Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Sci Signal 2010; 3:ra29; PMID:20388916; http://dx.doi. org/10.1126/scisignal.2000594.
17. Zhang H, Zuo Z, Lu X, Wang L, Wang H, Zhu Z. MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer. Oncol Rep 2012; 27:594-8; PMID:22076535.
18. Razumilava N, Bronk SF, Smoot RL, Fingas CD, Werneburg NW, Roberts LR, et al. miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma. Hepatology 2012; 55:465- 75; PMID:21953056; http://dx.doi.org/10.1002/ hep.24698.
19. Marchi S, Lupini L, Patergnani S, Rimessi A, Missiroli S, Bonora M, et al. Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25. Curr Biol 2013; 23:58-63; PMID:23246404; http:// dx.doi.org/10.1016/j.cub.2012.11.026.
20. Patergnani S, Suski JM, Agnoletto C, Bononi A, Bonora M, De Marchi E, et al. Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell Commun Signal 2011; 9:19; PMID:21939514; http://dx.doi.org/10.1186/1478- 811X-9-19.
21. Drawnel FM, Wachten D, Molkentin JD, Maillet M, Aronsen JM, Swift F, et al. Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. J Cell Biol 2012; 199:783-98; PMID:23166348; http://dx.doi. org/10.1083/jcb.201111095.
22. 2+ overload and cell death. J Clin Invest 2012; 122:1222-32; PMID:22426211; http://dx.doi. org/10.1172/JCI59327.
23. Ryu S, McDonnell K, Choi H, Gao D, Hahn M, Joshi N, et al. Suppression of miRNA-708 by polycomb group promotes metastases by calciuminduced cell migration. Cancer Cell 2013; 23:63- 76; PMID:23328481; http://dx.doi.org/10.1016/j. ccr.2012.11.019