EphrinA5-EphA7 complex induces apoptotic cell death via TNFR1

Molecules and Cells

Volumn 35, Issue 5, 2013, Pages 450-455

  Lee, Haeryung ^a   Park, Eunjeong ^a   Kim, Yujin ^a   Park, Soochul ^a  

^a Sookmyung Women's University   (South Korea)

Author keywords

apoptosis; EphA7; ephrinA5; TNFR1

Indexed keywords

EPHRIN RECEPTOR A5; EPHRIN RECEPTOR A7; MULTIPROTEIN COMPLEX; TUMOR NECROSIS FACTOR RECEPTOR 1; EPHA7 RECEPTOR, MOUSE; EPHRIN A5; TNFRSF1A PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOTINYLATION; CELL DEATH; CELL INTERACTION; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INCUBATION TEMPERATURE; INTERNALIZATION; LOW TEMPERATURE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; STIMULATION; ANIMAL; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; METABOLISM;

ANIMALS; APOPTOSIS; CELL DEATH; EPHRIN-A5; HEK293 CELLS; HUMANS; MICE; RECEPTOR, EPHA7; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84879113587     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-013-0072-3     Document Type: Article

References (21)

1. Brantley-Sieders, D.M., Zhuang, G., Hicks, D., Fang, W.B., Hwang, Y., Cates, J.M., Coffman, K., Jackson, D., Bruckheimer, E., Muraoka-Cook, R.S., et al. (2008). The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J. Clin. Invest. 118, 64-78.
2. Ciossek, T., Millauer, B., and Ullrich, A. (1995). Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system. Oncogene 10, 97-108.
3. de la Rosa, E.J., and de Pablo, F. (2000). Cell death in early neural development: beyond the neurotrophic theory. Trends Neurosci. 23, 454-458.
4. Depaepe, V., Suarez-Gonzalez, N., Dufour, A., Passante, L., Gorski, J.A., Jones, K.R., Ledent, C., and Vanderhaeghen, P. (2005). Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature 435, 1244-1250.
5. Gu, C., Shim, S., Shin, J., Kim, J., Park, J., Han, K., and Park, S. (2005). The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells. Oncogene 24, 4243-4256.
6. Hsu, H., Huang, J., Shu, H.B., Baichwal, V., and Goeddel, D.V. (1996a). TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4, 387-396.
7. Hsu, H., Shu, H.B., Pan, M.G., and Goeddel, D.V. (1996b). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84, 299-308.
8. Kuan, C.Y., Roth, K.A., Flavell, R.A., and Rakic, P. (2000). Mechanisms of programmed cell death in the developing brain. Trends Neurosci. 23, 291-297.
9. Lee, S.Y., Reichlin, A., Santana, A., Sokol, K.A., Nussenzweig, M.C., and Choi, Y. (1997). TRAF2 is essential for JNK but not NFkappaB activation and regulates lymphocyte proliferation and survival. Immunity 7, 703-713.
10. Lim, Y.S., McLaughlin, T., Sung, T.C., Santiago, A., Lee, K.F., and O'Leary, D.D. (2008). p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping. Neuron 59, 746-758.
11. Locksley, R.M., Killeen, N., and Lenardo, M.J. (2001). The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104, 487-501.
12. Marler, K.J., Becker-Barroso, E., Martinez, A., Llovera, M., Wentzel, C., Poopalasundaram, S., Hindges, R., Soriano, E., Comella, J., and Drescher, U. (2008). A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. J. Neurosci. 28, 12700-12712.
13. Noh, H., and Park, S. (2010). Ectopic expression of Ephrin-A5 under the EphA8 promoter at the anterior region of the superior colliculus. Exp. Neurobiol. 19, 49-53.
14. Park, E., Kim, Y., Noh, H., Lee, H., Yoo, S., and Park, S. (2013). EphA/ephrin-A signaling is critically involved in region-specific apoptosis during early brain development. Cell Death Differ. 20, 169-180.
15. Schneider-Brachert, W., Tchikov, V., Neumeyer, J., Jakob, M., Winoto-Morbach, S., Held-Feindt, J., Heinrich, M., Merkel, O., Ehrenschwender, M., Adam, D., et al. (2004). Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21, 415-428.
16. Schutze, S., and Schneider-Brachert, W. (2009). Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling. Results Probl. Cell Differ. 49, 63-85.
17. Schutze, S., Tchikov, V., and Schneider-Brachert, W. (2008). Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. Nat. Rev. Mol. Cell Biol. 9, 655-662.
18. Shin, J., Gu, C., Park, E., and Park, S. (2007). Identification of phospho-tyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function. Mol. Cell. Biol. 27, 8113-8126.
19. Wajant, H., Pfizenmaier, K., and Scheurich, P. (2003). Tumor necrosis factor signaling. Cell Death Differ. 10, 45-65.
20. Yeo, W., and Gautier, J. (2004). Early neural cell death: dying to become neurons. Dev. Biol. 274, 233-244.
21. Yoo, S., Kim, Y., Lee, H., and Park, S. (2012). A gene trap knockout of the Tiam-1 protein results in malformation of the early embryonic brain. Mol. Cells 34, 103-108.