Deletion of podocyte STAT3 mitigates the entire spectrum of HIV-1-associated nephropathy

AIDS

Volumn 27, Issue 7, 2013, Pages 1091-1098

  Gu, Leyi ^a,b   Dai, Yan ^a,c   Xu, Jin ^a   Mallipattu, Sandeep ^a   Kaufman, Lewis ^a   Klotman, Paul E ^d   He, John C ^a,e   Chuang, Peter Y ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Dedifferentiation; Glomerular disease; HIV 1 associated nephropathy; Kidney; Podocyte; STAT3

Indexed keywords

CXCL2 CHEMOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATROPHY; CELL DEDIFFERENTIATION; CELL HYPERPLASIA; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GLOMERULOPATHY; GLOMERULOSCLEROSIS; HUMAN IMMUNODEFICIENCY VIRUS 1 ASSOCIATED NEPHROPATHY; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; KIDNEY DISEASE; KIDNEY FAILURE; KIDNEY TUBULE CELL; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; VIRUS PATHOGENESIS; WEIGHT REDUCTION;

AIDS-ASSOCIATED NEPHROPATHY; ALBUMINURIA; ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; GENE DELETION; GENE EXPRESSION PROFILING; HIV INFECTIONS; HUMANS; KIDNEY GLOMERULUS; MICE; MICE, TRANSGENIC; MICRORNAS; PODOCYTES; REAL-TIME POLYMERASE CHAIN REACTION; SCLEROSIS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; WEIGHT LOSS;

EID: 84879113485     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32835f1ea1     Document Type: Article

References (31)

1. D'Agati V, Appel GB. HIV infection and the kidney. J Am Soc Nephrol 1997; 8:138-152.
2. Wyatt CM, Klotman PE, D'Agati VD. HIV-associated nephropathy: clinical presentation, pathology, and epidemiology in the era of antiretroviral therapy. Semin Nephrol 2008; 28:513-522.
3. Peters PJ, Moore DM, Mermin J, Brooks JT, Downing R, Were W, et al. Antiretroviral therapy improves renal function among HIV-infected Ugandans. Kidney Int 2008; 74:925-929.
4. Wyatt CM, Meliambro K, Klotman PE. Recent progress in HIV-associated nephropathy. Annu Rev Med 2012; 63:147-159.
5. Leventhal JS, Ross MJ. Pathogenesis of HIV-associated nephropathy. Semin Nephrol 2008; 28:523-534.
6. Zhong J, Zuo Y, Ma J, Fogo AB, Jolicoeur P, Ichikawa I, et al. Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy. Kidney Int 2005; 68:1048-1060.
7. Husain M, D'Agati VD, He JC, Klotman ME, Klotman PE. HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. AIDS 2005; 19:1975-1980.
8. He JC, Husain M, Sunamoto M, D'Agati VD, Klotman ME, Iyengar R, et al. Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. J Clin Invest 2004; 114:643-651.
9. Feng X, Lu TC, Chuang PY, Fang W, Ratnam K, Xiong H, et al. Reduction of Stat3 activity attenuates HIV-induced kidney injury. J Am Soc Nephrol 2009; 20:2138-2146.
10. Kopp JB, Klotman ME, Adler SH, Bruggeman LA, Dickie P, Marinos NJ, et al. Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. Proc Natl Acad Sci U S A 1992; 89:1577-1581.
11. Jacoby JJ, Kalinowski A, Liu MG, Zhang SS, Gao Q, Chai GX, et al. Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A 2003; 100:12929-12934.
12. Moeller MJ, Sanden SK, Soofi A, Wiggins RC, Holzman LB. Podocyte-specific expression of cre recombinase in transgenic mice. Genesis 2003; 35:39-42.
13. Takemoto M, Asker N, Gerhardt H, Lundkvist A, Johansson BR, Saito Y, et al. A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol 2002; 161:799-805.
14. Chuang PY, Dai Y, Liu R, He H, Kretzler M, Jim B, et al. Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus. PLoS One 2011; 6:e23566.
15. Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, et al. A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. Nat Med 2012; 18:580-588.
16. Bodi I, Abraham AA, Kimmel PL. Apoptosis in human immunodeficiency virus-associated nephropathy. Am J Kidney Dis 1995; 26:286-291.
17. Ross MJ, Fan C, Ross MD, Chu TH, Shi Y, Kaufman L, et al. HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells. J Acquir Immune Defic Syndr 2006; 42:1-11.
18. Snyder A, Alsauskas Z, Gong P, Rosenstiel PE, Klotman ME, Klotman PE, et al. FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. J Virol 2009; 83:11983-11988.
19. Rosenstiel PE, Gruosso T, Letourneau AM, Chan JJ, LeBlanc A, Husain M, et al. HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells. Kidney Int 2008; 74:1049-1058.
20. Ding M, Coward RJ, Jeansson M, Kim W, Quaggin SE. Regulation of Hypoxia-nducible Factor 2-Alpha is Essential for Integrity of the Glomerular Barrier. Am J Physiol Renal Physiol 2013; 304:F120-F126.
21. Godel M, Hartleben B, Herbach N, Liu S, Zschiedrich S, Lu S, et al. Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest 2011; 121:2197-2209.
22. Yamamoto T, Noble NA, Miller DE, Gold LI, Hishida A, Nagase M, et al. Increased levels of transforming growth factor-beta in HIV-associated nephropathy. Kidney Int 1999; 55:579-592.
23. Bodi I, Kimmel PL, Abraham AA, Svetkey LP, Klotman PE, Kopp JB. Renal TGF-beta in HIV-associated kidney diseases. Kidney Int 1997; 51:1568-1577.
24. Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE. Side-kick-1 is upregulated in glomeruli in HIV-associated nephropathy. J Am Soc Nephrol 2004; 15:1721-1730.
25. Korgaonkar SN, Feng X, Ross MD, Lu TC, D'Agati V, Iyengar R, et al. HIV-1 upregulates VEGF in podocytes. J Am Soc Nephrol 2008; 19:877-883.
26. Gupta SK, Eustace JA, Winston JA, Boydstun II, Ahuja TS, Rodriguez RA, et al. Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis 2005; 40:1559-1585.
27. Adolescents. PoAGfAa. Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. Dep. Health Hum. Serv.; 2011. pp. 1-167.
28. Page BD, Ball DP, Gunning PT. Signal transducer and activator of transcription 3 inhibitors: a patent review. Expert Opin Ther Pat 2011; 21:65-83.
29. Sansone P, Bromberg J. Targeting the interleukin-6/Jak/stat pathway in human malignancies. J Clin Oncol 2012; 30:1005-1014.
30. O'Shea JJ, Plenge R. JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity 2012; 36:542-550.
31. Berthier CC, Zhang H, Schin M, Henger A, Nelson RG, Yee B, et al. Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes 2009; 58:469-477.