A systematic review of the pharmacological management of orthostatic hypotension

International Journal of Clinical Practice

Volumn 67, Issue 7, 2013, Pages 633-646

  Ong, A C L ^a   Myint, P K ^a   Shepstone, L ^b   Potter, J F ^a  

^a NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPHOR; DOMPERIDONE; EPHEDRINE; FLUDROCORTISONE; MIDODRINE; OCTREOTIDE; PINDOLOL; PLACEBO; PYRIDOSTIGMINE; THREO 3,4 DIHYDROXYPHENYLSERINE;

BLOOD PRESSURE MEASUREMENT; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; HEAD TILTING; HUMAN; ORTHOSTATIC HYPOTENSION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SINGLE DRUG DOSE; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE;

ADULT; AGED; CARDIOVASCULAR AGENTS; DOUBLE-BLIND METHOD; FEMALE; FLUDROCORTISONE; HUMANS; HYPOTENSION, ORTHOSTATIC; MALE; MIDDLE AGED; MIDODRINE; OCTREOTIDE; PYRIDOSTIGMINE BROMIDE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SINGLE-BLIND METHOD; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84879109071     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/ijcp.12122     Document Type: Review

References (44)

1. ESC. Guidelines for the diagnosis and management of syncope (2009): the Task Force for the Diagnosis and Management of Syncope of the European Society of Cardiology (ESC). Eur Heart J 2009; 30: 2631-71.
2. Lahrmann H, Cortelli P, Hilz M, Mathias CJ, Struhal W, Tassinari M,. EFNS guidelines on the diagnosis and management of orthostatic hypotension. Eur J Neurol 2006; 13: 930-6.
3. Davis BR, Langford HG, Blaufox MD, Curb JD, Polk BF, Shulman NB,. The association of postural changes in systolic blood pressure and mortality in persons with hypertension: the Hypertension Detection and Follow-up Program experience. Circulation 1987; 75: 340-6.
4. Rose KM, Eigenbrodt ML, Biga RL, et al. Orthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk In Communities (ARIC) Study. Circulation 2006; 114: 630-6.
5. Poon IO, Braun U,. High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. J Clin Pharm Ther 2005; 30: 173-8.
6. Mader SL, Josephson KR, Rubenstein LZ,. Low prevalence of postural hypotension among community-dwelling elderly. JAMA 1987; 258: 1511-4.
7. Campbell IW, Ewing DJ, Clarke BF,. 9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. Diabetes 1975; 24: 381-4.
8. Decaux G,. Fludrocortisone in orthostatic hypotension. N Engl J Med 1979; 301: 1121-2.
9. Jankovic J, Gilden JL, Hiner BC, Kaufmann H, Brown DC, Coghlan CH, et al. Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine. Am J Med 1993; 95: 38-48.
10. Hoeldtke RD, Bryner KD, Hoeldtke ME, Hobbs G,. Treatment of postural tachycardia syndrome: a comparison of octreotide and midodrine. Clin Auton Res 2006; 16: 390-5.
11. Kaufmann H, Saadia D, Voustianiouk A,. Midodrine in neurally mediated syncope: a double-blind, randomized, crossover study. Ann Neurol 2002; 52: 342-5.
12. Bellamy GR, Hunyor SN,. The effect of dihydroergotamine on venous distensibility and blood pressure in idiopathic orthostatic hypotension. Aust N Z J Med 1984; 14: 157-9.
13. Bevegard S, Castenfors J, Lindblad LE,. Circulatory effects of dihydroergotamine in patients with disturbed sympathetic vasomotor control with special reference to postural hypotension. Cardiology 1976; 61 (Suppl. 1): 322-32.
14. Fouad FM, Tarazi RC, Bravo EL,. Dihydroergotamine in idiopathic orthostatic hypotension: short-term intramuscular and long-term oral therapy. Clin Pharmacol Ther 1981; 30: 782-9.
15. Birkmayer W, Birkmayer G, Lechner H, Riederer P,. DL-3,4-threo-DOPS in Parkinson's disease: effects on orthostatic hypotension and dizziness. J Neural Transm Gen Sect 1983; 58: 305-13.
16. Bordet R, Benhadjali J, Destee A, Belabbas A, Libersa C,. Octreotide effects on orthostatic hypotension in patients with multiple system atrophy: a controlled study of acute administration. Clin Neuropharmacol 1995; 18: 83-9.
17. Shibao C, Okamoto LE, Gamboa A, et al. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension 2010; 56: 847-51.
18. Montastruc JL, Chamontin B, Senard JM, Rascol A,. Domperidone in the management of orthostatic hypotension. Clin Neuropharmacol 1985; 8: 191-2.
19. Belz GG, Butzer R, Gaus W, Loew D,. Camphor-Crataegus berry extract combination dose-dependently reduces tilt induced fall in blood pressure in orthostatic hypotension. Phytomedicine 2002; 9: 581-8.
20. Claydon VE, Hainsworth R,. Salt supplementation improves orthostatic cerebral and peripheral vascular control in patients with syncope. Hypertension 2004; 43: 809-13.
21. Higgins JPT, Green S,. Chapter 8, Cochrane Handbook for Systematic reviews of Interventions Version 5.0.0 The Cochrane Collaboration www.cochrane.handbook.org 2008. (accessed 5 June 2009).
22. Kaufmann H, Brannan T, Krakoff L, Yahr MD, Mandeli J,. Treatment of orthostatic hypotension due to autonomic failure with a peripheral alpha-adrenergic agonist (midodrine). Neurology 1988; 38: 951-6.
23. Schoffer KL, Henderson RD, O'Maley K, O'Sullivan JD,. Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease. Mov Disord 2007; 22: 1543-9.
24. Fouad-Tarazi FM, Okabe M, Goren H,. Alpha sympathomimetic treatment of autonomic insufficiency with orthostatic hypotension. Am J Med 1995; 99: 604-10.
25. Low PA, Gilden JL, Freeman R, Sheng KN, McElligott MA,. Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension: a randomized, double-blind multicenter study. JAMA 1997; 277: 1046-51.
26. Cleophas TJ, Kauw FH, Bijl C, Meijers J, Stapper G,. Effects of beta adrenergic receptor agonists and antagonists in diabetics with symptoms of postural hypotension: a double-blind, placebo-controlled study. Angiology 1986; 37: 855-62.
27. Kroll M, Ring C, Gaus W, Hempel B,. A randomized trial of Korodin Herz-Kreislauf-Tropfen as add-on treatment in older patients with orthostatic hypotension. Phytomedicine 2005; 12: 395-402.
28. Wright RA, Kaufmann HC, Perera R, et al. A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension. Neurology 1998; 51: 120-4.
29. Kaufmann H, Saadia D, Voustianiouk A, Goldstein DS, Holmes C, Yahr MD, et al. Norepinephrine precursor therapy in neurogenic orthostatic hypotension. Circulation 2003; 108: 724-8.
30. Freeman R, Landsberg L, Young J,. The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trial. Neurology 1999; 53: 2151-7.
31. Singer W, Sandroni P, Opfer-Gehrking TL, et al. Pyridostigmine treatment trial in neurogenic orthostatic hypotension. Arch Neurol 2006; 63: 513-8.
32. Lahrmann H, Cortelli P, Hilz M, Mathias CJ, Struhal W, Tassinari M,. Orthostatic hypotension. In:, Gilhus NE, Barnes MP, Brainin M, eds. European Handbook of Neurological Managment: Volume 1, 2nd edn. Oxford: Wiley-Blackwell, 2010: 469-75.
33. Hickler RB, Thompson GR, Fox LM, Hamlin JT,. Successful treatment of orthostatic hypotension with 9-alpha-fluorohydrocortisone. N Engl J Med 1959; 261: 788-91.
34. Figueroa JJ, Basford JR, Low PA,. Preventing and treating orthostatic hypotension: as easy as A, B, C. Cleve Clin J Med 2010; 77: 298-306.
35. Deegan BMT, O'Connor M, Donnelly T, et al. Orthostatic hypotension: a new classification system. Europace 2007; 9: 937-41.
36. Low PA, Gilden JL, Freeman R, Sheng KN, McElligott MA,. Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group. [Erratum appears in JAMA 1997 Aug 6;278(5):388]. JAMA 1997; 277: 1046-51.
37. Freeman R,. Treatment of orthostatic hypotension. Semin Neurol 2003; 23: 435-42.
38. Hussain RM, McIntosh SJ, Lawson J, Kenny RA,. Fludrocortisone in the treatment of hypotensive disorders in the elderly. Heart 1996; 76: 507-9.
39. Pathak A, Raoul V, Montastruc JL, Senard JM,. Adverse drug reactions related to drugs used in orthostatic hyotension: a prospective and systematic pharmacovigilance study in France. Eur J Clin Pharmacol 2005; 61: 471-4.
40. Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally medicated syncope and the postural tachycardia syncrome. Clin Auton Res 2011; 21: 69-72.
41. Mattace-Raso FUS, van der Cammen TJ, Knetsch AM, et al. Arterial stiffness as the candidate underlying mechanism for postural blood pressure changes and orthostatic hypotension in older adults: the Rotterdam Study. J Hypertens 2006; 24: 339-44.
42. Protogerou AD, Stergiou GS, Lourida P, Achimastos A,. Arterial stiffness and orthostatic blood pressure changes in untreated and treated hypertensive subjects. J Am Soc Hypertens 2008; 2: 372-7.
43. Low PA,. Composite autonomic scoring scale for laboratory quantification of generalized autonomic failure. Mayo Clin Proc 1993; 68: 748-52.
44. Fan CW, Walsh C, Cunningham CJ,. The effect of sleeping with the head of the bed elevated six inches on elderly patients with orthostatic hypotension: an open randomised controlled trial. Age Ageing 2011; 40: 187-92.