Camphor-crataegus berry extract combination dose-dependently reduces tilt induced fall in blood pressure in orthostatic hypotension

Phytomedicine

Volumn 9, Issue 7, 2002, Pages 581-588

  Belz, G G ^a   Butzer, R ^a   Gaus, W ^b   Loew, D ^c  

^a ZeKaPha GmbH   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c Department of Pharmacology ^*  (Germany)

Author keywords

Blood pressure; Camphor; Crataegusberries extract; Hypotension; Orthostatic hypotension; Tilt table

Indexed keywords

CAMPHOR; CAMPHOR PLUS CRATAEGUS EXTRACT; CRATAEGUS EXTRACT; PLACEBO; PLANT EXTRACT; TROPFEN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECT; DRUG INDICATION; FEMALE; HUMAN; MALE; MEAN ARTERIAL PRESSURE; ORTHOSTATIC HYPOTENSION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TILT TABLE TEST;

CRATAEGUS; DRYOBALANOPS;

EID: 0036813135     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1078/094471102321616382     Document Type: Article

References (19)

1. Alli C, Avanzini F, Bettelli G, Colombo F, Corso R, Di Tullio M, Marchioli R, Mariotti G, Radice M, Taioli E, Terzian E, Tognoni G, Zussino A (1992) Prevalence and variability of orthoststic hypotension in the elderly: Results of the Italian study on blood pressure in the elderly (SPAA). Eur Heart J 13: 178-182
2. Applegate WB, Davis BR, Black HR, Smith WM, Miller ST, Burlando AJ (1991) Prevalance of postural hypotension at baseline in the systolic hypertension in the elderly program (SHEP) cohort. J Am Geriatr Soc 39: 1057-1064
3. Atkins D, Hanusa B, Sefcik T, Kapoor W (1991) Syncope and orthostatic hypotension. Am J Med 91: 179-185
4. Belz GG, Breithaupt-Grögler K, Butzer R, Herrmann V, Malerczyk C, Mang C, Roll S (2000) Klinische pharmakologie von d-campher. In: Phyto-pharmaka VI. Rietbrock N et al. (Hrsg), Steinkopff Verlag, pp. 21-28
5. Belz GG, Aust PE, Belz G (1981) Doppelblindstudie über die hämo-dynamischen wirkungen von amezinium bei patienten mit orthostatischer kreislaufregulationsstörung. Z Kardiol 70: 706-712
6. Consensus statement (1996) The definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy. J Auton Nervous Syst 58: 123-124
7. Gabard B, Trunzler G (1983) Zur Pharmakologie von Crataegus. In: Rietbrock N, Schnieders B, Schuster J, editors, Wandlungen in der Therapie der Herzinsuffizienz. Braunschweig: Friedr. Vieweg & Sohn: 43-53
8. Gaus W, Högel J (1992) Balanced designs for multiple crossover studies. Arzneimittelforschung 42: 163-172
9. Gesetz über den Verkehr von Arzneimitteln (AMG) in der Fassung des Gesetzes zur Neuordnung des Arzneimittelrechts von 1976 und ergänzt von 1996
10. Herrmann V, Butzer R, Roll S, Malerczyk C, Belz GG (1996) Hemodynamic responses to a cumulative dosage of Korodin Herz-Kreislauf-Tropfen. Eur J Clin Pharmacol 50: 544 (abstract)
11. ICH Harmonized Tripartite Guideline of Good Clinical Practice (ICH Topic E6) Adopted By CPMP, July 1996, issued as CPMP/ICH/135/95, Step 5
12. Lamarre-Cliche M, Cusson J (2001) The fainting patient: Value of the head-upright tilt-table test in adult patients with orthostatic intolerance. CMAJ 164: 372-376
13. Mader S (1989) Orthostatic hypotension. Med Clin North Am 73: 1337-1349
14. Mang C, Herrmann V, Butzer R, Roll S, Wolf GK, Belz GG (1997) Crataegus fructi extract: A placebo-controlled study on haemodynamic effects of single and repetitive doses in normal volunteers. Eur J Clin Pharmacol 52: A59 (abstract)
15. Masaki KH, Schatz IJ, Burchfiel CM, Sharp DS, Chiu D, Foley D, Curb D (1998) Orthostatic hypotension predicts mortality in elderly men: The Honolulu Heart Program. Circulation 98: 2290-2295
16. Masuo K, Mikami H, Ogihara T (1993) The frequency of ortostatic hypotension in elderly patients with essential hypertension, isolated systolic hyprtension and borderline hypertension. J Hypertens 11(Suppl 5): 306-307
17. Oldenburg O, Sack S, Erbel R, Phillipp T, Kribben A (1999) Therapie der orthostatischen hypotonie. Dtsch Med Wochenschr 124: 1209-1212
18. Raiha I, Luutonen S, Piha J, Seppanen A, Toikka T, Sourander L (1995) Prevalence, predisposing factors, and prognostic importance of postural hypotension. Arch Intern Med 155: 930-935
19. Rutan GH, Hermanson B, Bild DE, Kittner SJ, LaBaw F, Tell GS (1992) Orthostatic hypotension in older adults: The Cardiovascular Health Study. Hypertension 19: 508-519