A new flavan-3-ol dimer from Ficus spragueana leaves and its cytotoxic activity

Pharmacognosy Magazine

Volumn 9, Issue 34, 2013, Pages 144-148

  Ragab, Ehab A ^a   Mohammed, Abd El Salam I ^a   Abbass, Hatem S ^a   Kotb, Saaid I ^a  

^a Al Azhar University   (Egypt)

Author keywords

Cytotoxic activity; Ficus spragueana; Flavan 3 ol dimer; Moraceae

Indexed keywords

ACETIC ACID ETHYL ESTER; AFZELECHIN; AFZELECHIN (4-8) EPICATECHIN; DIMER; EPICATECHIN; FLAVAN 3 OL; FLAVONOID; SILICA GEL; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL STRUCTURE; CHROMATOGRAPHY; CONCENTRATION RESPONSE; CYTOTOXICITY; FICUS; FICUS SPRAGUEANA; HUMAN; HUMAN CELL; IC 50; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT LEAF;

EID: 84879105204     PISSN: 09731296     EISSN: 09764062     Source Type: Journal    
DOI: 10.4103/0973-1296.111274     Document Type: Article

References (24)

1. Van Noort S, Gardiner AJ, Tolley KA. New records of Ficus (Moraceae) species emphasize the conservation significance of inselbergs in Mozambique. South Afr J Bot 2007;73:642-9. (Pubitemid 47588481)
2. Ripu MK, Rainer WB. Ficus (Fig) species in Nepal: a review of diversity and indigenous uses. Lyonia 2006;11:85-97.
3. Abdel-Hameed ES. Total phenolic contents and free radical scavenging activity of certain Egyptian Ficus species leaf samples. Food Chem 2009;114:1271-7.
4. Kuetea V, Nanab F, Ngamenic B, Mbavengd AT, Keumedjio F, Ngadjuib BT. Antimicrobial activity of the crude extract, fractions and compounds from stem bark of Ficus ovata (Moraceae). J Ethnopharmacol 2009;124:556-61.
5. Pandita R, Phadkeb A, Jagtapa A. Antidiabetic effect of Ficus religiosa extract in streptozotocin-induced diabetic rats. J Ethnopharmacol 2010;128:462-6.
6. Savova ST, Ribarova F, Gerova M. (+)-Catechin and (-)-epicatechin in Bulgarian fruits. J Food Compos Anal 2005;18:691-8. (Pubitemid 40567908)
7. Veberic R, Colaric M, Stampar F. Phenolic acids and flavonoids of fig fruit (Ficus carica L.) in the Northern Mediterranean region. Food Chem 2008;106:153-7. (Pubitemid 47332100)
8. Kuo YH, Li YC. Three new compounds, ficusone, ficuspirolide and ficusolide from the heartwood of Ficus microcarpa. Chem Pharm Bull 1999;47:299-301.
9. Li YC, Kuo YH. Two New Isoflavones from the Bark of Ficus microcarpa. J Nat Prod 1997;60:292-3.
10. Li YC, Kuo YH. A monoterpenoids and two simple phenols from heartwood of Ficus microcarpa. Phytochemistry 1998;49:2417-9.
11. Chiang YM, Chang JY, Kuo CC, Chang CY, Kuo YH. Cytotoxic triterpenes from the aerial roots of Ficus microcarpa. Phytochemistry 2005;66:495-501.
12. Rubnov S, Kashman Y, Rabinowitz R, Schlesinger M, Mechoulam R. Suppressors of Cancer Cell Proliferation from Fig (Ficus carica) Resin: Isolation and Structure Elucidation. J Nat Prod 2001;64:993-6. (Pubitemid 32729927)
13. Baumgartner B, Erdelmeier CAJ, Wright AD, Rali T, Sticher O. An antimicrobial alkaloid from Ficus septic. Phytochemistry 1990;29:3327-30.
14. Johns SR, Russel JH. Ficine, a novel flavonoidal alkaloid from Ficus panfoniana. Tetrahedron Lett 1965;21:1987-91.
15. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983;65:55-63. (Pubitemid 14203433)
16. Francis D, Rita L. Rapid colorimetric assay for cell growth and survival: modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986;89:271-7.
17. Agrawal PK. Carbon-13 NMR of Flavonoids. New York: Elsevier Oxford; 1989.
18. Harborne JB. The Flavonoids, Advances in Research Since 1986. New York: Chapman and Hall; 1994.
19. Mabry TJ, Markham KR, Thomas MB. The Systematic Identification of Flavonoids. New York: Springer-Verlag; 1970.
20. 13C-NMR assignments of some green tea polyphenols. Magn Reson Chem 1996;34:887-90.
21. Jacques D, Haslam E, Bedford GR, Greatbanks D. Plant proanthocyanidins Part II. Proanthocyanidin-A2 and its derivatives. J Chem Soc 1974;I:2663-71.
22. Morimoto S, Nonaka G, Nishioka I. Tannins and related compounds, LIX. Aesculitanins, novel proanthocyanidins with doubly bonded structures from Aesculus hippocastanum L. Chem Pharm Bull 1987;35:4717-29.
23. Bruyne TD, Pieters LA, Dommisse RA, Kolodziej H, Wray V, Domke T, et al. Unambiguous assignments for free dimeric proanthocyanidin phenols from 2D NMR. Phytochemistry 1996;43:265-72. (Pubitemid 27065622)
24. Bae YS, Burger JF, Steynberg JP, Ferreira D, Hemingway RW. Flavan and procyanidin glycosides from the bark of Blackjack Oak. Phytochmistry 1994;3:473-8. (Pubitemid 2036637)