메뉴 건너뛰기




Volumn 130, Issue 1, 2013, Pages 75-80

Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in advanced-stage cervical and vaginal cancers

Author keywords

Cervical cancer; Radiosensitization; Ribonucleotide reductase; Triapine

Indexed keywords

3 AMINOPICOLINALDEHYDE THIOSEMICARBAZONE; CISPLATIN; FLUORODEOXYGLUCOSE F 18; RIBONUCLEOTIDE REDUCTASE;

EID: 84879097670     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2013.04.019     Document Type: Article
Times cited : (80)

References (38)
  • 1
    • 34447562948 scopus 로고    scopus 로고
    • Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: A Gynecologic Oncology Group Study
    • P. Rose, S. Ali, E. Watkins, J. Thigpen, G. Deppe, and D. Clark-Pearson Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: a Gynecologic Oncology Group Study J Clin Oncol 25 2007 2804 2810
    • (2007) J Clin Oncol , vol.25 , pp. 2804-2810
    • Rose, P.1    Ali, S.2    Watkins, E.3    Thigpen, J.4    Deppe, G.5    Clark-Pearson, D.6
  • 2
    • 35548963316 scopus 로고    scopus 로고
    • Radiation therapy with or without weekly cisplatin for bulky stage 1B cervical carcinoma: Follow-up of a Gynecologic Oncology Group trial
    • F. Stehman, S. Ali, H. Keys, L. Muderspach, W. Chafe, and D. Gallup Radiation therapy with or without weekly cisplatin for bulky stage 1B cervical carcinoma: follow-up of a Gynecologic Oncology Group trial Am J Obstet Gynecol 197 2007 503.e1 503.e6
    • (2007) Am J Obstet Gynecol , vol.197
    • Stehman, F.1    Ali, S.2    Keys, H.3    Muderspach, L.4    Chafe, W.5    Gallup, D.6
  • 5
    • 83055178964 scopus 로고    scopus 로고
    • 18F-fluoro-2-deoxy-d-glucose positron emission tomography standard uptake value as an indicator of cervical cancer chemoradiation therapeutic response
    • 18F-fluoro-2-deoxy-d-glucose positron emission tomography standard uptake value as an indicator of cervical cancer chemoradiation therapeutic response Int J Gynecol Cancer 21 2011 1117 1123
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 1117-1123
    • Kunos, C.1    Radivoyevitch, T.2    Abdul-Karim, F.3    Faulhaber, P.4
  • 6
    • 34548807963 scopus 로고    scopus 로고
    • Primary vaginal cancer treated with concurrent chemoradiation using cis-platinum
    • R. Samant, B. Lau, E C, T. Le, and T. Tam Primary vaginal cancer treated with concurrent chemoradiation using cis-platinum Int J Radiat Oncol Biol Phys 69 2007 746 750
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , pp. 746-750
    • Samant, R.1    Lau, B.2    Le, T.3    Tam, T.4
  • 8
    • 0032523834 scopus 로고    scopus 로고
    • Expression of ribonucleotide reductase after ionizing radiation in human cervical carcinoma cells
    • M.-L. Kuo, and T. Kinsella Expression of ribonucleotide reductase after ionizing radiation in human cervical carcinoma cells Cancer Res 58 1998 2245 2252
    • (1998) Cancer Res , vol.58 , pp. 2245-2252
    • Kuo, M.-L.1    Kinsella, T.2
  • 9
    • 0034594978 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
    • H. Tanaka, H. Arakawa, T. Yamaguchi, K. Shiraishi, S. Fukuda, and K. Matsui A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage Nature 404 2000 42 49
    • (2000) Nature , vol.404 , pp. 42-49
    • Tanaka, H.1    Arakawa, H.2    Yamaguchi, T.3    Shiraishi, K.4    Fukuda, S.5    Matsui, K.6
  • 10
    • 33646359442 scopus 로고    scopus 로고
    • Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells
    • P. Hakansson, A. Hofer, and L. Thelander Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells J Biol Chem 281 2006 7834 7841
    • (2006) J Biol Chem , vol.281 , pp. 7834-7841
    • Hakansson, P.1    Hofer, A.2    Thelander, L.3
  • 11
    • 67449158984 scopus 로고    scopus 로고
    • Changes in gene expression predicting local control in cervical cancer: Results from Radiation Therapy Oncology Group 0128
    • J. Weidhaas, S. Li, K. Winter, J. Ryu, A. Jhingran, and B. Miller Changes in gene expression predicting local control in cervical cancer: results from Radiation Therapy Oncology Group 0128 Clin Cancer Res 15 2009 4199 4206
    • (2009) Clin Cancer Res , vol.15 , pp. 4199-4206
    • Weidhaas, J.1    Li, S.2    Winter, K.3    Ryu, J.4    Jhingran, A.5    Miller, B.6
  • 12
    • 70549109318 scopus 로고    scopus 로고
    • Modulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 protein
    • C. Kunos, S. Chiu, J. Pink, and T. Kinsella Modulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 protein Radiat Res 172 2009 666 676
    • (2009) Radiat Res , vol.172 , pp. 666-676
    • Kunos, C.1    Chiu, S.2    Pink, J.3    Kinsella, T.4
  • 13
    • 77958091728 scopus 로고    scopus 로고
    • Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers
    • C. Kunos, T. Radivoyevitch, J. Pink, S. Chiu, T. Stefan, and J. Jaccobberger Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers Radiat Res 174 2010 574 581
    • (2010) Radiat Res , vol.174 , pp. 574-581
    • Kunos, C.1    Radivoyevitch, T.2    Pink, J.3    Chiu, S.4    Stefan, T.5    Jaccobberger, J.6
  • 14
    • 79959363029 scopus 로고    scopus 로고
    • Radiosensitization of human cervical cancer cells by inhibiting ribonucleotide reductase: Enhanced radiation response at low dose rates
    • C. Kunos, V. Colussi, J. Pink, T. Radivoyevitch, and N. Oleinick Radiosensitization of human cervical cancer cells by inhibiting ribonucleotide reductase: enhanced radiation response at low dose rates Int J Radiat Oncol Biol Phys 80 2011 1198 1204
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , pp. 1198-1204
    • Kunos, C.1    Colussi, V.2    Pink, J.3    Radivoyevitch, T.4    Oleinick, N.5
  • 15
    • 80053236914 scopus 로고    scopus 로고
    • Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers
    • C. Kunos, G. Ferris, N. Pyatka, J. Pink, and T. Radivoyevitch Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers Radiat Res 176 2011 425 433
    • (2011) Radiat Res , vol.176 , pp. 425-433
    • Kunos, C.1    Ferris, G.2    Pyatka, N.3    Pink, J.4    Radivoyevitch, T.5
  • 17
    • 1542398694 scopus 로고    scopus 로고
    • Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: An update of Radiation Therapy Oncology Group trial (RTOG) 90-01
    • P.J. Eifel, K. Winter, M. Morris, C. Levenback, P.W. Grigsby, and J. Cooper Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of Radiation Therapy Oncology Group trial (RTOG) 90-01 J Clin Oncol 22 2004 872 880
    • (2004) J Clin Oncol , vol.22 , pp. 872-880
    • Eifel, P.J.1    Winter, K.2    Morris, M.3    Levenback, C.4    Grigsby, P.W.5    Cooper, J.6
  • 18
    • 0032895783 scopus 로고    scopus 로고
    • Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: A Gynecologic Oncology Group and Southwest Oncology Group study
    • C.W. Whitney, W. Sause, B.N. Bundy, J.H. Malfetano, E.V. Hannigan, and W.C. Fowler Jr. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study J Clin Oncol 17 1999 1339 1348
    • (1999) J Clin Oncol , vol.17 , pp. 1339-1348
    • Whitney, C.W.1    Sause, W.2    Bundy, B.N.3    Malfetano, J.H.4    Hannigan, E.V.5    Fowler, Jr.W.C.6
  • 19
    • 79955582400 scopus 로고    scopus 로고
    • A phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix
    • A. Duenas-Gonzalez, J. Zarba, F. Patel, J. Alcedo, F. Beslija, and L. Casanova A phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix J Clin Oncol 29 2011 1678 1685
    • (2011) J Clin Oncol , vol.29 , pp. 1678-1685
    • Duenas-Gonzalez, A.1    Zarba, J.2    Patel, F.3    Alcedo, J.4    Beslija, F.5    Casanova, L.6
  • 20
    • 76749092292 scopus 로고    scopus 로고
    • Phase i trial of intravenous 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in combination with pelvic radiation therapy and weekly cisplatin chemotherapy for locally advanced cervical cancer
    • C. Kunos, S. Waggoner, V. Von Gruenigen, E. Eldermire, J. Pink, and A. Dowlati Phase I trial of intravenous 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in combination with pelvic radiation therapy and weekly cisplatin chemotherapy for locally advanced cervical cancer Clin Cancer Res 16 2010 1298 1306
    • (2010) Clin Cancer Res , vol.16 , pp. 1298-1306
    • Kunos, C.1    Waggoner, S.2    Von Gruenigen, V.3    Eldermire, E.4    Pink, J.5    Dowlati, A.6
  • 21
    • 84857347252 scopus 로고    scopus 로고
    • Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone induced methemoglobinemia
    • C. Kunos, T. Radivoyevitch, S. Ingalls, and C. Hoppel Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone induced methemoglobinemia Future Oncol 8 2012 145 150
    • (2012) Future Oncol , vol.8 , pp. 145-150
    • Kunos, C.1    Radivoyevitch, T.2    Ingalls, S.3    Hoppel, C.4
  • 22
    • 84872346050 scopus 로고    scopus 로고
    • Therapeutic mechanisms of treatment in cervical and vaginal cancer
    • C. Kunos Therapeutic mechanisms of treatment in cervical and vaginal cancer Oncol Hematol Rev 8 2012 55 60
    • (2012) Oncol Hematol Rev , vol.8 , pp. 55-60
    • Kunos, C.1
  • 27
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • E. Kaplan, and P. Meier Nonparametric estimation from incomplete observations J Am Stat Assoc 53 1958 457 481
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.1    Meier, P.2
  • 28
    • 0032580320 scopus 로고    scopus 로고
    • Two-sided confidence intervals for the single proportion: Comparison of seven methods
    • R. Newcombe Two-sided confidence intervals for the single proportion: comparison of seven methods Stat Med 17 1998 857 872
    • (1998) Stat Med , vol.17 , pp. 857-872
    • Newcombe, R.1
  • 29
    • 0033561333 scopus 로고    scopus 로고
    • Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer
    • P.G. Rose, B.N. Bundy, E.B. Watkins, J.T. Thigpen, G. Deppe, and M.A. Maiman Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer N Engl J Med 340 1999 1144 1153
    • (1999) N Engl J Med , vol.340 , pp. 1144-1153
    • Rose, P.G.1    Bundy, B.N.2    Watkins, E.B.3    Thigpen, J.T.4    Deppe, G.5    Maiman, M.A.6
  • 30
    • 77958091728 scopus 로고    scopus 로고
    • Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers
    • C. Kunos, T. Radivoyevitch, J. Pink, S. Chiu, T. Stefan, and J. Jacobberger Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers Radiat Res 174 2010 574 581
    • (2010) Radiat Res , vol.174 , pp. 574-581
    • Kunos, C.1    Radivoyevitch, T.2    Pink, J.3    Chiu, S.4    Stefan, T.5    Jacobberger, J.6
  • 31
    • 66249084554 scopus 로고    scopus 로고
    • Kinetics of H2AX phosphorylation after exposure to cisplatin
    • P. Olive, and J. Banath Kinetics of H2AX phosphorylation after exposure to cisplatin Cytometry Part B 76B 2009 79 90
    • (2009) Cytometry Part B , vol.76 B , pp. 79-90
    • Olive, P.1    Banath, J.2
  • 32
    • 84862165672 scopus 로고    scopus 로고
    • Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: A Gynecologic Oncology Group study
    • [1-10]
    • C. Kunos, T. Radivoyevitch, F. Abdul-Karim, J. Fanning, O. Abulafia, and A. Bonebrake Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group study J Transl Med 10 2012 79 [1-10]
    • (2012) J Transl Med , vol.10 , pp. 79
    • Kunos, C.1    Radivoyevitch, T.2    Abdul-Karim, F.3    Fanning, J.4    Abulafia, O.5    Bonebrake, A.6
  • 33
    • 80051789536 scopus 로고    scopus 로고
    • Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer
    • R. Pötter, P. Georg, J. Dimopoulos, M. Grimm, D. Berger, and N. Nesvacil Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer Radiother Oncol 100 2011 116 123
    • (2011) Radiother Oncol , vol.100 , pp. 116-123
    • Pötter, R.1    Georg, P.2    Dimopoulos, J.3    Grimm, M.4    Berger, D.5    Nesvacil, N.6
  • 34
    • 84860389451 scopus 로고    scopus 로고
    • Treatment of locally advanced vaginal cancer with radiochemotherapy and magnetic resonance image-guided adaptive brachytherapy: Dose-volume parameters and first clinical results
    • J. Dimopoulos, M. Schmid, E. Fidarova, D. Berger, C. Kirisits, and R. Pötter Treatment of locally advanced vaginal cancer with radiochemotherapy and magnetic resonance image-guided adaptive brachytherapy: dose-volume parameters and first clinical results Int J Radiat Oncol Biol Phys 82 2012 1880 1888
    • (2012) Int J Radiat Oncol Biol Phys , vol.82 , pp. 1880-1888
    • Dimopoulos, J.1    Schmid, M.2    Fidarova, E.3    Berger, D.4    Kirisits, C.5    Pötter, R.6
  • 35
    • 78649292701 scopus 로고    scopus 로고
    • Implementing chemoradiation treatment for patients with cervical cancer in a comprehensive cancer center community oncology practice
    • C. Kunos, G. Ferris, and S. Waggoner Implementing chemoradiation treatment for patients with cervical cancer in a comprehensive cancer center community oncology practice Commun Oncol 7 2010 446 450
    • (2010) Commun Oncol , vol.7 , pp. 446-450
    • Kunos, C.1    Ferris, G.2    Waggoner, S.3
  • 36
    • 70349942940 scopus 로고    scopus 로고
    • Chemotherapy administration during pelvic radiation for cervical cancer patients aged ≥ 55 years in the SEER-Medicare population
    • C. Kunos, H. Gibbons, F. Simpkins, and S. Waggoner Chemotherapy administration during pelvic radiation for cervical cancer patients aged ≥ 55 years in the SEER-Medicare population J Oncol 2008 2008 1 7
    • (2008) J Oncol , vol.2008 , pp. 1-7
    • Kunos, C.1    Gibbons, H.2    Simpkins, F.3    Waggoner, S.4
  • 37
    • 73449126941 scopus 로고    scopus 로고
    • Retrospective analysis of concomitant cisplatin during radiation in patients aged ≥ 55 years for treatment of advanced cervical cancer: A Gynecologic Oncology Group Study
    • C. Kunos, C. Tian, S. Waggoner, P. Rose, and R. Lanciano Retrospective analysis of concomitant cisplatin during radiation in patients aged ≥ 55 years for treatment of advanced cervical cancer: a Gynecologic Oncology Group Study Int J Gynecol Cancer 19 2009 1258 1263
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 1258-1263
    • Kunos, C.1    Tian, C.2    Waggoner, S.3    Rose, P.4    Lanciano, R.5
  • 38
    • 84859776781 scopus 로고    scopus 로고
    • A phase i and pharmacokinetic study of oral 3-aminopyridine-2- carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced stage solid cancers-A California Cancer Consortium Study
    • J. Chao, T. Synold, R. Morgan Jr., C. Kunos, J. Longmate, and H.-J. Lenz A phase I and pharmacokinetic study of oral 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced stage solid cancers-a California Cancer Consortium Study Cancer Chemother Pharmacol 69 2012 835 843
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 835-843
    • Chao, J.1    Synold, T.2    Morgan, Jr.R.3    Kunos, C.4    Longmate, J.5    Lenz, H.-J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.