Efficacy of vitamin D loading doses on serum 25-hydroxy vitamin D levels in school going adolescents: An open label non-randomized prospective trial

Journal of Pediatric Endocrinology and Metabolism

Volumn 26, Issue 5-6, 2013, Pages 515-523

  Garg, M K ^b   Marwaha, Raman K ^a,c   Khadgawat, Rajesh ^d   Ramot, Rekha ^d   Obroi, Avneet Kaur ^d   Mehan, Neena ^e   Gupta, Nandita ^d   Madan, Renu ^b  

^a Gautam Apartments   (India)

^b ARMY HOSPITAL RESEARCH AND REFERRAL   (India)

^c ILSI India   (India)

^d ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^e BR sur Homeopathy Medical College   (India)

Author keywords

Adolescents; Vitamin D deficiency; Vitamin D supplementation

Indexed keywords

ALKALINE PHOSPHATASE; CALCIFEDIOL; CALCIUM; COLECALCIFEROL; PHOSPHATE;

ADOLESCENT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; CALCIUM BLOOD LEVEL; CHILD; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; LOADING DRUG DOSE; MAINTENANCE DRUG DOSE; MAJOR CLINICAL STUDY; OPEN STUDY; PHOSPHATE BLOOD LEVEL; PROSPECTIVE STUDY; SCHOOL CHILD; TREATMENT DURATION; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

ADOLESCENT; ANIMALS; BODY MASS INDEX; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOOD, FORTIFIED; HUMANS; INDIA; MALE; MILK; PROSPECTIVE STUDIES; VITAMIN D; VITAMIN D DEFICIENCY; VITAMINS;

EID: 84879061131     PISSN: 0334018X     EISSN: 21910251     Source Type: Journal    
DOI: 10.1515/jpem-2012-0390     Document Type: Article

References (26)

1. Hollick MF. Vitamin D deficiency. N Engl J Med 2007;357: 266-81.
2. Harinarayan CV, Joshi S R. Vitamin D status in India-its implications and remedial measures. J Assoc Phys India 2009;57:40-8.
3. Hollick MF. Vitamin D: Extraskeletal health. Endocrinol Metab Clin N Am 2010;39: 381-400.
4. Durup D, Jørgensen HL, Christensen J, Schwarz P, Heegaard AM, et al. A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: The CopD study. J Clin Endocrinol Metab 2012;97:2644-52.
5. Thomas GN, Hartaigh B, Bosch JA, Pilz S, Loerbroks A, et al. Vitamin D levels predict all-cause and cardiovascular disease mortality in subjects with the metabolic syndrome: The Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. Diabetes Care 2012;35:1158-64.
6. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 2009;20:1807-20.
7. Marwaha RK, Tandon N, Reddy DR, Aggaral R, Singh R, et al. Vitamin D and bone mineral density of healthy school children in northern India. Am J Clin Nutr 2005;82:477-82.
8. Puri S, Marwaha RK, Agarwal N, Tandon N, Agarwal R, et al. Vitamin D status of apparently healthy schoolgirls from two different socioeconomic strata in Delhi: Relation to nutrition and lifestyle. Br J Nutr 2008;99:876-82. (Pubitemid 351351644)
9. Winzenberg T, Jones G. Vitamin D and Bone health in childhood and adolescence, Calcif Tissue Int 2012; DOI 10.1007/s00223-012-9615-4.
10. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96:1911-30.
11. Marwaha RK, Khadgawat R, Tandon N, Kanwar R, Narang A, et al. Reference intervals of serum calcium, ionized calcium, phosphate and alkaline phosphatase in healthy Indian school children and adolescents. Clin Biochem 2010; 43:1216-9.
12. Metz MP. Determining urinary calcium/creatinine cut-offs for the paediatric population using published data. Ann Clin Biochem 2006;43:398-401. (Pubitemid 44526540)
13. van Groningen L, Opdenoordt S, van Sorge A, Telting D, Giesen A, et al. Cholecalciferol loading dose guideline for vitamin D-deficient adults. Eur J Endocrinol 2010;162:805-11.
14. Goswami R, Gupta N, Goswami D, Marwaha RK, Tandon N, et al. Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi. Am J Clin Nutr 2000;72:472-5. (Pubitemid 30620654)
15. Marwaha RK, Tandon N, Agarwal N, Puri S, Agarwal R, et al. Impact of two regimens of vitamin D supplementation on calcium-vitamin D-PTH axis of schoolgirls of Delhi. Indian Pediatr 2010;47:761-9.
16. Khadilkar AV, Sayyad MG, Sanwalka NJ, Bhandari DR, Naik S, et al. Vitamin D supplementation and bone mass accrual in underprivileged adolescent Indian girls. Asia Pac J Clin Nutr 2010;19:465-72.
17. Carnes J, Quinn S, Nelson M, Jones G, Winzenberg T. Intermittent high-dose vitamin D corrects vitamin D deficiency in adolescents: A pilot study. Eur J ClinNutr 2012;66:530-2.
18. Duhamel JF, Zeghoud F, Sempé M, Boudailliez B, Odièvre M, et al. Prevention of vitamin D deficiency in adolescents and pre-adolescents. An interventional multicenter study on the biological effect of repeated doses of 100,000 IU of vitamin D3. Arch Pediatr 2000;7:148-53. (Pubitemid 30091005)
19. Guillemant J, Le HT, Maria A, Allemandou A, Pér̀s G, et al. Wintertime vitamin D deficiency in male adolescents: Effect on parathyroid function and response to vitamin D3 supplements. Osteoporos Int 2001;12:875-9. (Pubitemid 33086276)
20. Maalouf J, Nabulsi M, Vieth R, Kimball S, El-Rassi R, et al. Short-and long-term safety of weekly high-dose vitamin D3 supplementation in school children. J Clin Endocrinol Metab 2008;93:2693-701. (Pubitemid 352008538)
21. Dahifar H, Faraji A, Ghorbani A, Yassobi S. Impact of dietary and lifestyle on vitamin D in healthy student girls aged 11-15 years. J Med Invest 2006;53:204-8. (Pubitemid 44619837)
22. Ghazi AA, Hosseinpanah F, Mardakani E, Ghazi S, Hedayati M, et al. Effects of different doses of oral cholecalciferol on serum 25(OH)D, PTH, calcium and bone markers during fall and winter in schoolchildren. Eur J Clin Nutr 2010;64:1415-22.
23. Goswami R, Gupta N, Ray D, Singh N, Tomar N. Pattern of 25-hydroxy vitamin D response at short (2 month) and long (1 year) interval after 8 weeks of oral supplementation with cholecalciferol in Asian Indians with chronic hypovitaminosis D. Br J Nutr 2008;100:526-9.
24. Autier P, Gandini S, Mullie P. A systematic review: Influence of vitamin D supplementation on serum 25-hydroxyvitamin D concentration. J Clin Endocrinol Metab 2012;97:2606-13.
25. Rajakumar K, Fernstrom JD, Holick MF, Janosky JE, Greenspan SL. Vitamin D status and response to Vitamin D(3) in obese vs. non-obese African American children. Obesity (Silver Spring) 2008;16:90-5. (Pubitemid 351271955)
26. Emel T, Doǧan DA, Erdem G, Faruk O. Therapy strategies in vitamin D deficiency with or without rickets: Efficiency of low-dose stoss therapy. J Pediatr Endocr Metab 2012;25:107-10.