The effect of oral contraceptives on aromatase and Cox-2 expression in the endometrium of patients with idiopathic menorrhagia or adenomyosis

International Journal of Women's Health

Volumn 5, Issue 1, 2013, Pages 293-299

  Maia, Hugo ^a,b,c   Haddad, Clarice ^c   Pinheiro, Nathaniel ^a   Casoy, Julio ^c  

^a FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^b Itaigara Memorial Day Hospital   (Brazil)

^c Centro De Pesquisa E Assistencia Em Reproducao Humana   (Brazil)

Author keywords

Adenomyosis; Aromatase; Cox 2; Endometrium; Menorrhagia

Indexed keywords

AROMATASE; CYCLOOXYGENASE 2; DROSPIRENONE PLUS ETHINYLESTRADIOL; ETHINYLESTRADIOL PLUS GESTODENE; GESTINOL; ORAL CONTRACEPTIVE AGENT; UNCLASSIFIED DRUG;

ADENOMYOSIS; ARTICLE; CONTROLLED STUDY; ENDOMETRIUM; FEMALE; HUMAN; HUMAN TISSUE; HYSTEROSCOPY; IDIOPATHIC MENORRHAGIA; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MENORRHAGIA; METRORRHAGIA; PROTEIN EXPRESSION;

EID: 84879049886     PISSN: None     EISSN: 11791411     Source Type: Journal    
DOI: 10.2147/IJWH.S45093     Document Type: Article

References (25)

1. Smith OP, Jabour HN, Critchley HP. Cyclooxygenase enzyme expression and E series prostaglandin receptor signalling are enhanced in heavy menstruation. Hum Reprod. 2007;22(5):1450-1456.
2. Maia HJ, Casoy J. Non-contraceptive health benefits of oral contraceptives. Eur J Contracept Reprod Health Care. 2008;13(1): 17-24.
3. Fraser IS, Kovacs GT. The efficacy of non-contraceptive uses for hormonal contraceptives. Med J Aust. 2003;178(12):621-623.
4. Maia H Jr, Maltez A, Coelho G, Athayde C, Coutinho EM. Insertion of Mirena after endometrial resection in patients with adenomyosis. J Am Assoc Gynecol Laparosc. 2003;10(4):512-516.
5. Maia H Jr, Maltez A, Studard E, Zausner B, Athayde C, Coutinho E. Effect of menstrual cycle and oral contraceptives on cycloooxygenase-2 expression in the endometrium. Gynecol Endocrinol. 2005;21(1):57-61.
6. Koike H, Egawa H, Ohtsuka T, Yamaguchi M, Ikenoue T, Mori N. Correlation between dysmenorrheic severity and prostaglandin production in women with endometriosis. Prostaglandins Leukot Essent Fatty Acids. 1992;46(2):133-137.
7. Noble LS, Takayama K, Zeitoun KM. Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab. 1997;82(2):600-606.
8. Bulun S, Gurates B, Fang Z, et al. Mechanisms of excessive estrogen formation in endometriosis. J Reprod Immunol. 2002;55(1):21-33.
9. Maia H Jr, Haddad C, Casoy J. Correlation between aromatase expression in the eutopic endometrium of symptomatic patients and the presence of endometriosis. Int J Women's Health. 2012;4:61-65.
10. Ferenczy A. Pathophysiology of adenomyosis. Hum Reprod Update. 1998;4(4):312-322.
11. Maia H Jr, Casoy J, Valente Filho J. Is aromatase expression in the endometrium the cause of endometriosis and its related infertility? Gynecol Endocrinol. 2010;26(4):253-257.
12. Maia H Jr, Pimentel K, Casoy J, et al. Aromatase expression in the eutopic endometrium of myomatous uteri: the influence of the menstrual cycle and oral contraceptive use. Gynecol Endocrinol. 2007;23(6): 320-324.
13. Maia H Jr, Casoy J, Correia T, Freitas A, Pimentel K, Coutinho EM. Effect of the menstrual cycle and oral contraceptives on aromatase and cycooxygenase-2 expression in adenomyosis. Gynecol Endocrinol. 2006;22(10):1-5.
14. Maia H Jr, Casoy J, Correia T, Freitas LA, Pimentel K, Athayde C. The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis. Gynecol Endocrinol. 2008; 24(3):123-128.
15. Baskin GB, Smith SM, Marx PA. Endometrial hyperplasia, polyps and adenomyosis associated with unopposed estrogens in rhesus monkeys (Macaca mulatta). Vet Pathol. 2002;39(5):572-575.
16. Maia H Jr, Casoy J, Pimentel K, et al. Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies. Contraception. 2008;78(6):479-485.
17. McLucas B. Does endometrial resection cause adenomyosis? J Am Assoc Gynecol Laparosc. 1994;1(4 Part 2):S21.
18. Quemere MP, Cravello L, Roger V, d'Ercole C, Blanc B. [Impact of adenomyosis on results of endometrial ablations.] Contracept Fertil Sex. 1999;27(5):357-363. French.
19. Hatok J, Zubor P, Galo S, et al. Endometrial aromatase mRNA as a possible screening tool for advanced endometriosis and adenomyosis. Gynecol Endocrinol. 2011;27(5):331-336.
20. Maia H Jr, Casoy J, Correia T, Athayde C, Valente J, Coutinho EM. Activation of NF-kappaB and COX-2 expression is associated with breakthrough bleeding in patients using oral contraceptives in extended regimens. Gynecol Endocrinol. 2010;26(4):265-269.
21. Fechner S, Husen B, Thole H, et al. Expression and regulation of estrogen-converting enzymes in ectopic human endometrial tissue. Fertil Steril. 2007;88(Suppl 4):1029-1038.
22. Yamanaka K, Xu B, Suganuma I, et al. Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture. Fertil Steril. 2012;97(2):477-482.
23. Maia H Jr, Haddad C, Coelho G, Casoy J. Role of inflammation and aromatase expression in the eutopic endometrium and its relationship with the development of endometriosis. Women's Health (Lond Engl). 2012;8(6):647-658.
24. Maia H Jr, Haddad C, Pinheiro N, Casoy J. Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain. Int J Women's Health. 2012;4:543-549.
25. Munro MG, Critchley HO, Broder MS, Fraser IS; FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet. 2011;113(1):3-13.