Aromatase expression in the eutopic endometrium of myomatous uteri: The influence of the menstrual cycle and oral contraceptive use

Gynecological Endocrinology

Volumn 23, Issue 6, 2007, Pages 320-324

  Maia Jr , Hugo ^a   Pimentel, Kleber ^b   Casoy, Júlio ^a   Correia, Tânia ^b,c,d   Freitas, Luis Antonio R ^c,d   Zausner, Bela ^e   Athayde, Célia ^a   Coutinho, Elsimar ^a  

^a Centro De Pesquisa E Assistencia Em Reproducao Humana   (Brazil)

^b ESCOLA BAHIANA DE MEDICINA E SAÚDE PÚBLICA   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^e Genese   (Brazil)

Author keywords

Aromatase; Endometrium; Menorrhagia; Myomas; Oral contraceptives

Indexed keywords

AROMATASE; CYTOCHROME P450; ETHINYLESTRADIOL; GESTINOL; GESTODENE; ORAL CONTRACEPTIVE AGENT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLEEDING; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOMETRIUM; FEMALE; HUMAN; HUMAN TISSUE; HYSTEROSCOPY; IMMUNOHISTOCHEMISTRY; LUTEAL PHASE; MAJOR CLINICAL STUDY; MENORRHAGIA; MENSTRUAL CYCLE; MYOMECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR LOCALIZATION; UTERUS MYOMA;

ADULT; AROMATASE; CONTRACEPTIVES, ORAL; ENDOMETRIUM; FEMALE; FOLLICULAR PHASE; HUMANS; IMMUNOHISTOCHEMISTRY; LUTEAL PHASE; MENORRHAGIA; MENSTRUAL CYCLE; MIDDLE AGED; RETROSPECTIVE STUDIES; UTERINE NEOPLASMS;

EID: 34447132027     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.1080/09513590701321565     Document Type: Article

References (24)

1. Rein MS, Barbiere RL, Friedman AJ. Progesterone: a critical role in pathogenesis of myomas. Am J Obstet Gynecol 1995;172:14-18.
2. Otsuka H, Shinohara M, Kashimura M, Yoshida K, Okamura Y. A comparative study of the estrogen receptor ratio in myometrium and uterine leiomyomas. Int J Gynecol Obstet 1989;29:189-194.
3. Kataoka S, Yamada H, Hoshi N, Kudo M, Hareyama H, Sakuragi N, Fugimoto S. Cytogenetic analysis of uterine leiomyoma: the size, histopathology and GnRH a response in relation to chromosome karyotype. Eur J Obstet Gyecol Reprod Biol 2003;110:58-62.
4. Crow J. Pathology of uterine fibroids. Baillieres Clin Obstet Gynecol 1998;12:197-211.
5. Brosens I, Deprest J, Dal Cin P, Van den Berghe H. Clinical significance of cytogenetic abnormalities in uterine myomas. Fertil.Steril 1998;69:232-235.
6. Maia H Jr, Barbosa IC, Farias JR, Coutinho EM. Endometrial abnormalities in patients with intramural and submucous myoma. Contracept Fertil Sex 1995;23(Suppl 9):S44.
7. Brandon DD, Erickson TE, Keenan EJ, Strawn EY, Novy MJ, Burry KA, Warner C, Clinton CM. Estrogen receptor gene expression in human uterine leiomyomata. J Clin Endocrinol Metab 1995;78:1876-1880.
8. Shozu M, Murakami K, Inoue M. Aromatase and leiomyoma of the uterus. Semin Reprod Med 2004;22:51-60.
9. Kitawaki J, Noguchi T, Amatsu T, Maeda K, Tsukamoto K, Yamamoto T, Fushiki S, Osawa Y, Honjo H. Expression of aromatase cytochrome p450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissue but not in normal endometrium. Biol Reprod 1997;57:514-519.
10. Attar E. Aromatase and other steroidogenic genes in endometriosis. Translational aspects. Hum Reprod Update 2006;12:49-56.
11. Maia H Jr, Pimentel K, Silva TM, Freitas LA, Zausner B, Athayde C, Coutinho EM. Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle. Gynecol Endocrinol 2006;2:219-224.
12. Sugino N, Kashida S, Karube-Harada A, Takiquchi S, Kato H. Expression of vascular endothelial growth factor and its receptor in human endometrium throughout the menstrual cycle and early pregnancy. Reproduction 2002;123:379-389.
13. Girling JE, Rogers PA. Recent advances in endometrial angiogenesis research. Angiogenesis 2005;8:89-99.
14. Jensen JT, Speroff L. Health benefits of oral contraceptives. Obstet Gynecol Clin North Am 2000;27:705-722.
15. Orsini G, Laricchia L, Fanelli M. Low dose combination oral contraceptive use in women with uterine leiomyomas. Minerva Ginecol 2002;54:253-261.
16. Ishira H. Gonadotrophin-releasing hormone agonist and danazol normalize aromatase cytochrome p450 expression in eutopic endometrium from women with endometriosis, adenomyosis or leiomyomas. Fertil Steril 2003;79(Suppl 1):735-742.
17. Maia H Jr, Casoy J, Correia T, Freitas A, Pimentel K, Coutinho EM. Effect of the menstrual cycle and oral contraceptives on aromatase and cyclooxygenase-2 expression in adenomyosis. Gynecol Endocrinol 2006;22:1-5.
18. Shozu M, Sumitani H, Segawa T, Yang HJ, Murakami K, Kasai T, Inoue M. Overexpressiom of aromatase P450 in leiomyoma tissue is driven through the promoter I.4 of the aromatase P450 gene (CYP19). J Clin Endocrinol Metab 2002;87:2540-2548.
19. 2 stimulates aromatase activity in endometriosis derived stromal cells. J Clin Endocrinol Metab 1997;82:600-606.
20. Bulun SE, Gurates B, Fang Z, Tamura M, Sebastian S, Zhou J, Amin S, Yang S. Mechanisms of excessive estrogen formation in endometriosis. J Reprod Immunol 2002;55:21-33.
21. Ebert AD, Bartley J, David M. Aromatase inhibitors and cyclooxygenase-2 (COX-2) inhibitors in endometriosis: new questions - old answers? Eur J Obstet Gynecol Reprod Biol 2005;122:144-150.
22. Baskin GB, Smith SM, Marx PA. Endometrial hyperplasia, polyps and adenomyosis associated with unopposed estrogens in rhesus monkey (Macaca mulata). Vet Pathol 2002;39:572-575.
23. Ross RK, Pike MC, Vessey MP, Bull D, Yeates D, Casagrande JT. Risk factors for uterine fibroids: reduced risk associated with oral contraceptives. Br Med J (Clin Res Ed) 1986;293:359-362.
24. Chiaffarino F, Parazzini F, Vechia C. Use of oral contraceptives and uterine fibroids. Results from a case-control study. Br J Obstet Gynaecol 1999;106:857-860.