Isolation, purification, and immunological activities of a low-molecular-weight polysaccharide from the lingzhi or reishi medicinal mushroom ganoderma lucidum (Higher Basidiomycetes)

International Journal of Medicinal Mushrooms

Volumn 15, Issue 4, 2013, Pages 407-414

  Zhu, Lina ^a,b,c   Luo, Xi ^a,b,d   Tang, Qingjiu ^a,b   Liu, Yanfang ^a,b   Zhou, Shuai ^a,b   Yang, Yan ^a,b   Zhang, Jingsong ^a,b  

^a AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

^b Shanghai Key Laboratory of Agricultural Genetics and Breeding   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

Ganoderma lucidum; Immunological activity; Isolation; Medicinal mushrooms; Polysaccharide; Purification

Indexed keywords

FUNGAL EXTRACT; FUNGAL POLYSACCHARIDE; GANODERMA LUCIDUM EXTRACT; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MONOSACCHARIDE; NITRIC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CELL PROLIFERATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FUNGUS ISOLATION; GANODERMA LUCIDUM; GEL FILTRATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNITY; ION EXCHANGE CHROMATOGRAPHY; MACROPHAGE; MEDICINAL MUSHROOM; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PURIFICATION; SPLEEN LYMPHOCYTE;

ANIMALS; CELL LINE; GANODERMA; GENE EXPRESSION REGULATION; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-6; LYMPHOCYTES; MACROPHAGES; MICE; MICE, INBRED BALB C; POLYSACCHARIDES; SPLEEN;

BASIDIOMYCOTA; GANODERMA LUCIDUM;

EID: 84879041180     PISSN: 15219437     EISSN: 19404344     Source Type: Journal    
DOI: 10.1615/IntJMedMushr.v15.i4.80     Document Type: Article

References (19)

1. Liu JP, Liu XP. Immunological activities and preparations of Ganoderma lucidum. Tianjin Pharm. 2004;16:43-5.
2. Hu BJ, Shi ZZ, Zhao P. Study on Ganoderma lucidum polysaccharide biology function and its extract method. Heilongjiang Med J. 2007;20:207-9.
3. Han JJ, Deng W, Qi XG, Yang ZX, Zhang L. Effect on activation of NK cells by Ganoderma lucidum polysaccharide. J Taishan Med Coll. 2002;23:155-56.
4. Chen SM, Wang Q, Cheng YM, Xu J. Activation of proteoglycans from Ganoderma lucidum. Acta Edulis Fungi. 1997;4:40-42.
5. Dong CJ. Extraction of polysaccharide from Ganoderma lucidum and effect on the immunological function of mouse. J Hubei Teachers Coll. 2001;21:72-7.
6. Chen WX, Lu Y, Wang AY, Yang B. Antitumor effect of polysaccharides from Ganoderma lucidum by different extraction methods. J Nanjing Univ Trad Chin Med. 2003;19:227-28.
7. Li XQ, Yang XT. Advanced in polysaccharides from Ganoderma lucidum. China New Med. 2004;3:57-60.
8. Luo SH, Yang H. Regulation of blood glucose by polysaccharides from Ganoderma lucidum. J Guangdong Pharm Coll. 2000;16:119-20.
9. Zhang RY, Wang CB, Mo EJ. Clinical study on comprehensive therapy of chronic hepatitis B [J]. Tianjin J Trad Chin Med. 2001;18:8-9.
10. Tanioka A, An WW, Kuge T, Tsubaki K, Nakaya K. Barley low molecular weight beta-glucan potently induces maturation of mouse dendritic cells. Anticancer Res. 2011;31:1647-51.
11. Li J, Matsumoto S, Nakamura A, Maeda H, Matsumura Y. Characterization and functional properties of sub-fractions of soluble soybean polysaccharides. Biosci Biotechnol Biochem. 2009;73:2568-75.
12. Zhang JS, Tang QJ, Zimmerman-Kordmann M, Werner R, Fan H. Activation of B lymphocytes by GLIS, a bioactive proteoglycan from Ganoderma lucidum. Life Sci. 2002;71:623-38.
13. Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH, Lin CH, Wong CH. Studies on the immune-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorg Med Chem. 2004;12:5595-601.
14. Kuo MC, Weng CY, Ha CL, Wu MJ. Canoderma lucidum mycelia enhance innate immunity by activating NF-kB. J Ethnopharmacol. 2006;103:217-22.
15. Dai ZL, Dong CW. Research progress in biological activity of polysaccharide from Canoderma lucidum. J Anhui Trad Chin Med Coll. 2005;24:60-62.
16. Tang QJ, Zhang JS, Pan YJ, Zimmerman-Kordmann M, Werner R, Fan H. Activation of normal and tumor-bearing mouse macrophages by active polysaccharide from Ganoderma lucidum. Curr Immunol. 2005;25:49-55.
17. Liu W, Wang HY, Pang WB, Gao XD. Characterization and antioxidant activating of two low-molecular-weight polysaccharides purified from the fruiting bodies of Ganoderma lucidum. Int J Biol Macromol. 2010;46:451-57.
18. Jiang Y, Wang H, Lü L, Tian GY. Chemistry of polysaccharide Lzps-1 from Ganoderma lucidum spore and anti-tumor activity of its total polysaccharides. Acta Pharmaceut Sin. 2005;40:347-50.
19. Wei GQ, Lü LH, Chen YL, Zhao LQ. Preparation and anti-tumor activity of low molecular weight exopolysaccharide from Rhizobium sp. N613. Microbiology. 2011;38:123-29.