Effects of Administration of Live or Inactivated Virulent Rhodococccus equi and Age on the Fecal Microbiome of Neonatal Foals

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Bordin, Angela I ^a   Suchodolski, Jan S ^a   Markel, Melissa E ^a   Weaver, Kaytee B ^a   Steiner, Jörg M ^a   Dowd, Scot E ^b   Pillai, Suresh ^c   Cohen, Noah D ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Molecular Research DNA Laboratory   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; CHOLERA TOXIN B SUBUNIT; INACTIVATED VACCINE; LIVE VACCINE;

AGE; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL VIRULENCE; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; FOAL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOASSAY; LOW DRUG DOSE; MICROBIAL DIVERSITY; MICROBIOME; NEWBORN; NONHUMAN; PHYLOGENY; PYROSEQUENCING; RHODOCOCCUS EQUI; VACCINATION; VALIDATION PROCESS;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BACTERIAL VACCINES; FECES; HORSES; MICROBIOTA; MOLECULAR TYPING; RHODOCOCCUS EQUI; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, DNA; VACCINES, INACTIVATED; VACCINES, LIVE, UNATTENUATED;

RHODOCOCCUS EQUI;

EID: 84879033845     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066640     Document Type: Article

References (53)

1. Meijer WG, Prescott JF, (2004) Rhodococcus equi. Veterinary Research 35: 383-396.
2. Muscatello G, Leadon DP, Klayt M, Ocampo-Sosa A, Lewis DA, et al. (2007) Rhodococcus equi infection in foals: the science of 'rattles'. Equine Vet J 39: 470-478.
3. Prescott JF, (1991) Rhodococcus equi: an animal and human pathogen. Clin Microbiol Rev 4: 20-34.
4. Takai S, (1997) Epidemiology of Rhodococcus equi infections: a review. Vet Microbiol 56: 167-176.
5. Giguère S, Cohen ND, Chaffin MK, Hines SA, Hondalus MK, et al. (2011) Rhodococcus equi: clinical manifestations, virulence, and immunity. Journal of Veterinary Internal Medicine 25: 1221-1230.
6. Jain S, Bloom BR, Hondalus MK, (2003) Deletion of vapA encoding Virulence Associated Protein A attenuates the intracellular actinomycete Rhodococcus equi. Mol Microbiol 50: 115-128.
7. Dawson TR, Horohov DW, Meijer WG, Muscatello G, (2010) Current understanding of the equine immune response to Rhodococcus equi. An immunological review of R. equi pneumonia. Vet Immunol Immunopathol 135: 1-11.
8. Harris SP, Fujiwara N, Mealey RH, Alperin DC, Naka T, et al. (2010) Identification of Rhodococcus equi lipids recognized by host cytotoxic T lymphocytes. Microbiology 156: 1836-1847.
9. Patton KM, McGuire TC, Hines MT, Mealey RH, Hines SA, (2005) Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals. Infection and Immunity 73: 2083-2093.
10. Horowitz ML, Cohen ND, Takai S, Becu T, Chaffin MK, et al. (2001) Application of Sartwell's model (lognormal distribution of incubation periods) to age at onset and age at death of foals with Rhodococcus equi pneumonia as evidence of perinatal infection. Journal of Veterinary Internal Medicine 15: 171-175.
11. Chaffin MK, Cohen ND, Martens RJ, (2008) Chemoprophylactic effects of azithromycin against Rhodococcus equi-induced pneumonia among foals at equine breeding farms with endemic infections. Journal of the American Veterinary Medical Association 232: 1035-1047.
12. Chirino-Trejo JM, Prescott JF, Yager JA, (1987) Protection of foals against experimental Rhodococcus equi pneumonia by oral immunization. Can J Vet Res 51: 444-447.
13. Hooper-McGrevy KE, Wilkie BN, Prescott JF, (2005) Virulence-associated protein-specific serum immunoglobulin G-isotype expression in young foals protected against Rhodococcus equi pneumonia by oral immunization with virulent R. equi. Vaccine 23: 5760-5767.
14. van der Geize R, Grommen AW, Hessels GI, Jacobs AA, Dijkhuizen L, (2011) The steroid catabolic pathway of the intracellular pathogen Rhodococcus equi is important for pathogenesis and a target for vaccine development. PLoS Pathogens 7: e1002181.
15. Arnold H, Bumann D, Felies M, Gewecke B, Sorensen M, et al. (2004) Enhanced immunogenicity in the murine airway mucosa with an attenuated Salmonella live vaccine expressing OprF-OprI from Pseudomonas aeruginosa. Infection and Immunity 72: 6546-6553.
16. Villena J, Medina M, Raya R, Alvarez S, (2008) Oral immunization with recombinant Lactococcus lactis confers protection against respiratory pneumococcal infection. Canadian Journal of Microbiology 54: 845-853.
17. KuoLee R, Harris G, Conlan JW, Chen W, (2007) Oral immunization of mice with the live vaccine strain (LVS) of Francisella tularensis protects mice against respiratory challenge with virulent type A F. tularensis. Vaccine 25: 3781-3791.
18. Clark SO, Kelly DL, Badell E, Castello-Branco LR, Aldwell F, et al. (2010) Oral delivery of BCG Moreau Rio de Janeiro gives equivalent protection against tuberculosis but with reduced pathology compared to parenteral BCG Danish vaccination. Vaccine 28: 7109-7116.
19. Tompkins DM, Buddle BM, Whitford J, Cross ML, Yates GF, et al. (2013) Sustained protection against tuberculosis conferred to a wildlife host by single dose oral vaccination. Vaccine 31: 893-899.
20. Ancelet LR, Aldwell FE, Rich FJ, Kirman JR, (2012) Oral vaccination with lipid-formulated BCG induces a long-lived, multifunctional CD4(+) T cell memory immune response. PLoS ONE 7: e45888.
21. Garrido JM, Sevilla IA, Beltran-Beck B, Minguijon E, Ballesteros C, et al. (2011) Protection against tuberculosis in Eurasian wild boar vaccinated with heat-inactivated Mycobacterium bovis. PLoS ONE 6: e24905.
22. Quan FS, Compans RW, Kang SM, (2012) Oral vaccination with inactivated influenza vaccine induces cross-protective immunity. Vaccine 30: 180-188.
23. Sealy R, Webby RJ, Crumpton JC, Hurwitz JL (2012) Differential localization and function of antibody-forming cells responsive to inactivated or live-attenuated influenza virus vaccines. Int Immunol.
24. Paillot R, Prowse L, Montesso F, Huang CM, Barnes H, et al. (2013) Whole inactivated equine influenza vaccine: Efficacy against a representative clade 2 equine influenza virus, IFNgamma synthesis and duration of humoral immunity. Vet Microbiol 162: 396-407.
25. Mshvildadze M, Neu J, (2010) The infant intestinal microbiome: friend or foe? Early Human Development 86Suppl 1: 67-71.
26. Murgas Torrazza R, Neu J, (2011) The developing intestinal microbiome and its relationship to health and disease in the neonate. Journal of Perinatology 31Suppl 1: S29-34.
27. Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO, (2007) Development of the human infant intestinal microbiota. PLoS Biology 5: e177.
28. Inman CF, Laycock GM, Mitchard L, Harley R, Warwick J, et al. (2012) Neonatal colonisation expands a specific intestinal antigen-presenting cell subset prior to CD4 T-cell expansion, without altering T-cell repertoire. PLoS ONE 7: e33707.
29. Willing BP, Van Kessel AG, (2007) Enterocyte proliferation and apoptosis in the caudal small intestine is influenced by the composition of colonizing commensal bacteria in the neonatal gnotobiotic pig. Journal of Animal Science 85: 3256-3266.
30. Halbert ND, Reitzel RA, Martens RJ, Cohen ND, (2005) Evaluation of a multiplex polymerase chain reaction assay for simultaneous detection of Rhodococcus equi and the vapA gene. American Journal of Veterinary Research 66: 1380-1385.
31. Mashoof S, Goodroe A, Du CC, Eubanks JO, Jacobs N, et al. (2012) Ancient T-independence of mucosal IgX/A: gut microbiota unaffected by larval thymectomy in Xenopus laevis. Mucosal Immunology.
32. Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, et al. (2011) Metagenomic biomarker discovery and explanation. Genome Biol 12: R60.
33. Garcia-Mazcorro JF, Dowd SE, Poulsen J, Steiner JM, Suchodolski JS, (2012) Abundance and short-term temporal variability of fecal microbiota in healthy dogs. Microbiologyopen 1: 340-347.
34. Suchodolski JS, Markel ME, Garcia-Mazcorro JF, Unterer S, Heilmann RM, et al. (2012) The fecal microbiome in dogs with acute diarrhea and idiopathic inflammatory bowel disease. PLoS ONE 7: e51907.
35. Hochberg Y, (1988) A sharper Bonferroni procedure for multiple tests of significance. Biometrika 75: 800-802.
36. Shannon CE, Weaver W (1963) The mathematical theory of communication. Urbana, IL: University of Illinois Press.
37. Chao A, (1987) Estimating the population size for capture-recapture data with unequal catchability. Biometrics 43: 783-791.
38. Garcia-Mazcorro JF, Lanerie DJ, Dowd SE, Paddock CG, Grutzner N, et al. (2011) Effect of a multi-species synbiotic formulation on fecal bacterial microbiota of healthy cats and dogs as evaluated by pyrosequencing. FEMS Microbiol Ecol 78: 542-554.
39. Venturi A, Gionchetti P, Rizzello F, Johansson R, Zucconi E, et al. (1999) Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis. Aliment Pharmacol Ther 13: 1103-1108.
40. Vitali B, Ndagijimana M, Cruciani F, Carnevali P, Candela M, et al. (2010) Impact of a synbiotic food on the gut microbial ecology and metabolic profiles. BMC Microbiol 10: 4.
41. Jia J, Frantz N, Khoo C, Gibson GR, Rastall RA, et al. (2011) Investigation of the faecal microbiota of kittens: monitoring bacterial succession and effect of diet. FEMS Microbiol Ecol 78: 395-404.
42. Minamoto Y, Hooda S, Swanson KS, Suchodolski JS, (2012) Feline gastrointestinal microbiota. Animal Health Research Reviews 13: 64-77.
43. Buddington RK, (2003) Postnatal changes in bacterial populations in the gastrointestinal tract of dogs. Am J Vet Res 64: 646-651.
44. Scholtens PA, Oozeer R, Martin R, Amor KB, Knol J, (2012) The early settlers: intestinal microbiology in early life. Annu Rev Food Sci Technol 3: 425-447.
45. Shepherd ML, Swecker WS Jr, Jensen RV, Ponder MA, (2012) Characterization of the fecal bacteria communities of forage-fed horses by pyrosequencing of 16S rRNA V4 gene amplicons. FEMS Microbiology Letters 326: 62-68.
46. Daly K, Stewart CS, Flint HJ, Shirazi-Beechey SP, (2001) Bacterial diversity within the equine large intestine as revealed by molecular analysis of cloned 16S rRNA genes. FEMS Microbiology Ecology 38: 141-151.
47. Costa M, Sturgeon A, Arroyo LG, Staempfli H, Weese JS. The horse's 2nd genome; metagenomic investigation of the equine intestinal microbiome; 2011; Denver, Colorado.
48. Suchodolski JS, (2011) Companion animals symposium: microbes and gastrointestinal health of dogs and cats. Journal of Animal Science 89: 1520-1530.
49. Fanaro S, Chierici R, Guerrini P, Vigi V (2003) Intestinal microflora in early infancy: composition and development. Acta Paediatrica Supplement 91: 48-55.
50. Smith P, MacDonald TT, Blumerg RS (2013) Principles of Mucosal Immunology. New York, NY: Garland Science. 529 p.
51. Dougal K, Harris PA, Edwards A, Pachebat JA, Blackmore TM, et al. (2012) A comparison of the microbiome and the metabolome of different regions of the equine hindgut. FEMS Microbiol Ecol 82: 642-652.
52. Whitehead AE, Parreira VR, Hewson J, Watson JL, Prescott JF, (2012) Development of a live, attenuated, potential vaccine strain of R. equi expressing vapA and the virR operon, and virulence assessment in the mouse. Vet Immunol Immunopathol 145: 479-484.
53. Giguère S, Cohen ND, Chaffin MK, Slovis NM, Hondalus MK, et al. (2011) Diagnosis, treatment, control, and prevention of infections caused by Rhodococcus equi in foals. Journal of Veterinary Internal Medicine 25: 1209-1220.