The use of P300-based BCIs in amyotrophic lateral sclerosis: From augmentative and alternative communication to cognitive assessment

Brain and Behavior

Volumn 2, Issue 4, 2012, Pages 479-498

  Cipresso, Pietro ^a   Carelli, Laura ^b   Solca, Federica ^b   Meazzi, Daniela ^a   Meriggi, Paolo ^c   Poletti, Barbara ^b   Lulé, Dorothée ^d   Ludolph, Albert C ^d   Silani, Vincenzo ^b   Riva, Giuseppe ^a  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

Amyotrophic lateral sclerosis; Augmentative and alternative communication; Brain computer interface; Cognitive assessment; P300

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; AUDITORY STIMULATION; BRAIN COMPUTER INTERFACE; COGNITION; COGNITIVE DEFECT; COMMUNICATION AID; ELECTROENCEPHALOGRAM; EQUIPMENT DESIGN; EVENT RELATED POTENTIAL; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; LEARNING; LONGITUDINAL STUDY; MAGNETOENCEPHALOGRAPHY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RELIABILITY; REVIEW; SIGNAL PROCESSING; SKILL; TACTILE STIMULATION; VISUAL STIMULATION;

EID: 84879027911     PISSN: None     EISSN: 21623279     Source Type: Journal    
DOI: 10.1002/brb3.57     Document Type: Review

References (137)

1. Abe, K., H. Fujimura, K. Toyooka, S. Sakoda, S. Yorifuji, and T. Yanagihara. 1997. Cognitive function in amyotrophic lateral sclerosis. J. Neurol Sci.148:95-100.
2. Abrahams, S., L. H. Goldstein, J. J. Kew, D. J. Brooks, C. M. Lloyd, C. D. Frith, and P. N. Leigh. 1996. Frontal lobe dysfunction in amyotrophic lateral sclerosis. A PET study. Brain119:2105-2120.
3. Abrahams, S., L. H. Goldstein, A. Al-Chalabi, A. Pickering, R. G. Morris, R. E. Passingham, D. J. Brooks, and P. N. Leigh. 1997. Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. J. Neurol. Neurosurg. Psychiatry62:464-472.
4. Abrahams, S., P. N. Leigh, A. Harvey, G. N. Vythelingum, D. Grisé, and L. H. Goldstein. 2000. Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia38:734-747.
5. Abrahams, S., L. H. Goldstein, J. Suckling, V. Ng, A. Simmons, X. Chitnis, L. Atkins, S. C. Williams, and P. N. Leigh. 2005a. Frontotemporal white matter changes in amyotrophic lateral sclerosis. J. Neurol.252:321-331.
6. Abrahams, S., P. N. Leigh, and L. H. Goldstein. 2005b. Cognitive change in ALS: a prospective study. Neurology64:1222-1226.
7. Anastasia, A., and S. Urbina. 1997. Psychological testing, 7th ed. Prentice Hall, Upper Saddle River, NJ.
8. Bai, O., P. Lin, D. Huang, D. Y. Fei, and M. K. Floeter. 2010. Towards a user-friendly brain-computer interface: initial tests in ALS and PLS patients. Clin. Neurophysiol.121:1293-1303.
9. Bak, T. H., and J. R. Hodges. 2004. The effects of motor neurone disease on language: further evidence. Brain Lang. 89:354-361.
10. Beukelman, D. R., S. Fager, L. Ball, and A. Dietz. 2007. AAC for adults with acquired neurological conditions: a review. Augment. Altern. Commun.23:230-242.
11. Birbaumer, N., T. Elbert, B. Rockstroh, and W. Lutzenberger. 1986. Biofeedback of slow cortical potentials in attentional disorders. Pp. 440-442inW. C. McCallum, R. Zappoli, and F. Denoth, eds. Cerebral psychophysiology: studies in event-related potentials. Elsevier, Amsterdam.
12. Birbaumer, N., N. Ghanayim, T. Hinterberger, I. Iversen, B. Kotchoubey, A. Kübler, J. Perelmouter, E. Taub, and H. Flor. 1999. A spelling device for the paralysed. Nature398:297-298.
13. Birbaumer, N., T. Hinterberger, A. Kübler, and N. Neumann. 2003. The thought-translation device (TTD): neurobehavioral mechanisms and clinical outcome. IEEE Trans. Neural Syst. Rehabil. Eng.11:120-123.
14. Brouwer, A. M., and J.B. van Erp. 2010. A tactile P300 brain-computer interface. Front Neurosci. 4:19.
15. Brownell, B., D. R. Oppenheimer, and J. T. Hughes. 1970. The central nervous system in motor neurone disease. J. Neurol. Neurosurg. Psychiatry33:338-357.
16. Brunner, P., S. Joshi, S. Briskin, J. R. Wolpaw, H. Bischof, and G. Schalk. 2010. Does the "P300" speller depend on eye gaze?J. Neural Eng.7:1-9.
17. Cipresso, P., P. Meriggi, L. Carelli, F. Solca, D. Meazzi, B. Poletti, D. Lule, A. C. Ludolph, G. Riva, and V. Silani. 2011. The combined use of brain computer interface and eye-tracking technology for cognitive assessment in amyotrophic lateral sclerosis. 5th International Conference on Pervasive Computing Technologies for Healthcare (PervasiveHealth), Dublin, Republic of Ireland, pp. 320-324.
18. Cipresso, P., P. Meriggi, L. Carelli, F. Solca, B. Poletti, D. Lulé, A. C. Ludolph, V. Silani, and G. Riva. 2012. Brain computer interface and eye-tracking for neuropsychological assessment of executive functions: a pilot study. In Proceedings of the 2nd International Workshop on Computing Paradigms for Mental, Vilamoura, Algarve, Portugal. DOI: 10.5220/0003893100790088.
19. Citi, L., R. Poli, and C. Cinel. 2010. Documenting, modelling and exploiting P300 amplitude changes due to variable target delays in Donchin's speller. J. Neural. Eng.7:056006.
20. David, A. S., and R. A. Gillham. 1986. Neuropsychological study of motor neuron disease. Psychosomatics27:441-445.
21. Donchin, E. 1981. Presidential address, 1980. Surprise!... Surprise?Psychophysiology18:493-513.
22. Donchin, E., K. M. Spencer, and R. Wijesinghe. 2000. The mental prosthesis: assessing the speed of a P300-based brain-computer interface. IEEE Trans. Rehabil. Eng.8:174-179.
23. Doran, M., J. H. Xuereb, and J. R. Hodges. 1995. Rapidly progressive aphasia with bulbar motor neurone disease: a clinical and neuropsychological study. Behav. Neurol.8:169-180.
24. Duncan-Johnson, C. C., and E. Donchin. 1982. The P300 component of the event-related brain potential as an index of information processing. Biol. Psychol.14:1-52.
25. Eisen, A., and C. Krieger. 1993. Pathogenic mechanisms in sporadic amyotrophic lateral sclerosis. Can. J. Neurol Sci.20:286-296.
26. Evdokimidis, I., T. S. Constantinidis, P. Gourtzelidis, N. Smyrnis, I. Zalonis, P. V. Zis, E. Andreadou, and C. Papageorgiou. 2002. Frontal lobe dysfunction in amyotrophic lateral sclerosis. J. Neurol Sci.195:25-33.
27. Fabiani, M., G. Gratton, D. Karis, and E. Donchin. 1987. Definition, identification and reliability of the P300 component of the event-related brain potential. inP. K. Ackles, J. R. Jennings, and M. G. H. Coles, eds. Advances in psychophysiology. JAI Press, New York, NY.
28. Farwell, L. A., and E. Donchin. 1988. Talking off the top of your head: toward a mental prosthesis utilizing event-related brain potentials. Electroencephalogr. Clin. Neurophysiol.70:510-523.
29. Freeman, W. J., M. D. Holmes, B. C. Burke, and S. Vanhatalo. 2003. Spatial spectra of scalp EEG and EMG from awake humans. Clin. Neurophysiol.114:1053-1068.
30. Furdea, A., S. Halder, D. J. Krusienski, D. Bross, F. Nijboer, N. Birbaumer, A. Kübler. 2009. An auditory oddball (P300) spelling system for brain-computer interfaces. Psychophysiology46:617-625.
31. Gallagher, J. P. 1989. Pathologic laughter and crying in ALS: a search for their origin. Acta Neurol. Scand.80:114-117.
32. Gallassi, R., P. Montagna, A. Morreale, S. Lorusso, P. Tinuper, R. Daidone, and E. Lugaresi. 1989. Neuropsychological, electroencephalogram and brain computed tomography findings in motor neuron disease. Eur. Neurol.29:115-120.
33. Gil, R., J. P. Neau, M. Dary-Auriol, C. Agbo, A. M. Tantot, and P. Ingrand. 1995. Event-related auditory evoked potentials and amyotrophic lateral sclerosis. Arch. Neurol.52:890-896.
34. Girardi, A., S. E. Macpherson, and S. Abrahams. 2011. Deficits in emotional and social cognition in amyotrophic lateral sclerosis. Neuropsychology25:53-65.
35. Gonsalvez, C. L., and J. Polich. 2002. P300 amplitude is determined by target-to-target interval. Psychophysiology39:388-396.
36. Grosskreutz, J., J. Kaufmann, J. Frädrich, R. Dengler, H. J. Heinze, and T. Peschel. 2006. Widespread sensorimotor and frontal cortical atrophy in Amyotrophic Lateral Sclerosis. BMC Neurol. 6:17.
37. Grossman, A. B., S. Woolley-Levine, W. G. Bradley, and R. G. Miller. 2007. Detecting neurobehavioral changes in amyotrophic lateral sclerosis. Amyotroph. Lateral Scler.8:56-61.
38. Guger, C., G. Edlinger, W. Harkam, I. Niedermayer, and G. Pfurtscheller. 2003. How many people are able to operate an EEG-based brain-computer interface (BCI)?IEEE Trans. Neural Syst. Rehabil. Eng.11:145-147.
39. Guger, C., S. Daban, E. Sellers, C. Holzner, G. Krausz, R. Carabalona, F. Gramatica, and G. Edlinger. 2009. How many people are able to control a P300-based brain-computer interface (BCI)?. Neurosci. Lett.462:94-98.
40. Hagen, G. F., J. R. Gatherwright, B. A. Lopez, and J. Polich. 2006. P3a from visual stimuli: task difficulty effects. Int. J. Psychophysiol.59:8-14.
41. Han, J., and L. Ma. 2010. Study of the features of proton MR spectroscopy ((1)H-MRS) on amyotrophic lateral sclerosis. J. Magn. Reson. Imaging31:305-308.
42. Hanagasi, H. A., I. H. Gurvit, N. Ermutlu, G. Kaptanoglu, S. Karamursel, H. A. Idrisoglu, M. Emre, and T. Demiralp. 2002. Cognitive impairment in amyotrophic lateral sclerosis: evidence from neuropsychological investigation and event-related potentials. Brain Res. Cogn. Brain Res.14:234-244.
43. Hill, N. J., T. N. Lal, M. Schröder, T. Hinterberger, B. Wilhelm, F. Nijboer, U. Mochty, G. Widman, C. Elger, B. Schölkopf, et al. 2006. Classifying EEG and ECoG signals without subject training for fast BCI implementation: comparison of nonparalyzed and completely paralyzed subjects. IEEE Trans. Neural Syst. Rehabil. Eng.14:183-186.
44. Hinterberger, T., R. Veit, B. Wilhelm, N. Weiskopf, J. J. Vatine, and N. Birbaumer. 2005. Neuronal mechanisms underlying control of a brain-computer interface. Eur. J. Neurosci.21:3169-3181.
45. Hoffmann, U., J. M. Vesin, T. Ebrahimi, and K. Diserens. 2008. An efficient P300-based brain-computer interface for disabled subjects. J. Neurosci. Methods167:115-125.
46. Irwin, D., C. F. Lippa, and J. M. Swearer. 2007. Cognition and amyotrophic lateral sclerosis (ALS). Am. J. Alzheimers Dis. Other Demen.22:300-312.
47. Iversen, I. H., N. Ghanayim, A. Kübler, N. Neumann, N. Birbaumer, and J. Kaiser. 2008a. A brain-computer interface tool to assess cognitive functions in completely paralyzed patients with amyotrophic lateral sclerosis. Clin. Neurophysiol.119:2214-2223.
48. Iversen, I., N. Ghanayim, A. Kübler, N. Neumann, N. Birbaumer, and J. Kaiser. 2008b. Conditional associative learning examined in a paralyzed patient with amyotrophic lateral sclerosis using brain-computer interface technology. Behav. Brain Funct.4:53.
49. Iwasaki, Y., M. Kinoshita, K. Ikeda, K. Takamiya, and T. Shiojima. 1990. Cognitive impairment in amyotrophic lateral sclerosis and its relation to motor disabilities. Acta Neurol. Scand. 81:141-143.
50. Jokelainen, M. 1977. Amyotrophic lateral sclerosis in Finland. I: an epidemiologic study. Acta Neurol. Scand. 56:185-193.
51. Kew, J. J., L. H. Goldstein, P. N. Leigh, S. Abrahams, N. Cosgrave, R. E. Passingham, R. S. Frackowiak, and D. J. Brooks. 1993. The relationship between abnormalities of cognitive function and cerebral activation in amyotrophic lateral sclerosis. A neuropsychological and positron emission tomography study. Brain116:1399-1423.
52. Kleih, S. C., F. Nijboer, S. Halder, and A. Kübler. 2010. Motivation modulates the P300 amplitude during brain -computer interface use. Clin. Neurophysiol.121:1023-1031.
53. Klobassa, D. S., T. M. Vaughan, P. Brunner, N. E. Schwartz, J. R. Wolpaw, C. Neuper, and E. W. Sellers. 2009. Toward a high-throughput auditory P300-based brain-computer interface. Clin. Neurophysiol.120:1252-1261.
54. Kotchoubey, B., et al. 1997. A new method for self-regulation of slow cortical potentials in a timed paradigm. Appl. Psychophysiol. Biofeedback22:77-93.
55. Krusienski, D. J., E. W. Sellers, F. Cabestaing, S. Bayoudh, D. J. McFarland, T. M. Vaughan, and J. R. Wolpaw. 2006. A comparison of classification techniques for the P300 Speller. J. Neural. Eng.3:299-305.
56. Kübler, A., and N. Birbaumer. 2008. Brain-computer interfaces and communication in paralysis: extinction of goal directed thinking in completely paralysed patients?Clin. Neurophysiol.119:2658-2666.
57. Kubler, and A., and K. R. Muller. 2007. Toward brain-computer interfacing. Pp. 72-79inA. Nijholt, D. S. Tan, G. Pfurtscheller, C. Brunner, J. del R. Millán, B. Allison, B. Graimann, F. Popescu, B. Blankertz, and K.-R. Möller, eds. Brain computer interfacing for intelligent systems. MIT Press, Boston.
58. Kübler, A., B. Kotchoubey, T. Hinterberger, N. Ghanayim, J. Perelmouter, M. Schauer, C. Fritsch, E. Taub, and N. Birbaumer. 1999. The thought translation device: a neurophysiological approach to communication in total motor paralysis. Exp. Brain Res.124:223-232.
59. Kübler, A., N. Neumann, J. Kaiser, B. Kotchoubey, T. Hinterberger, and N. P. Birbaumer. 2001a. Brain-computer communication: self-regulation of slow cortical potentials for verbal communication. Arch. Phys. Med. Rehabil.82:1533-1539.
60. Kübler, A., B. Kotchoubey, J. Kaiser, J. R. Wolpaw, and N. Birbaumer. 2001b. Brain-computer communication: unlocking the locked in. Psychol. Bull.127:358-375.
61. Kübler, A., F. Nijboer, J. Mellinger, T. M. Vaughan, H. Pawelzik, G. Schalk, D. J. McFarland, N. Birbaumer, and J. R. Wolpaw. 2005. Patients with ALS can use sensorimotor rhythms to operate a brain-computer interface. Neurology64:1775-1777.
62. Kwong, L. K., M. Neumann, D. M. Sampathu, V. M. Lee, and J. Q. Trojanowski. 2007. TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. Acta Neuropathol. 114:63-70.
63. Leuthardt, E. C., G. Schalk, J. Roland, A. Rouse, D. W. Moran. 2009. Evolution of brain-computer interfaces: going beyond classic motor physiology. Neurosurg. Focus27:E4.
64. Lomen-Hoerth, C., J. Murphy, S. Langmore, J. H. Kramer, R. K. Olney, and B. Miller. 2003. Are amyotrophic lateral sclerosis patients cognitively normal?Neurology60:1094-1097.
65. Ludolph, A. C., K. J. Langen, M. Regard, H. Herzog, B. Kemper, T. Kuwert, I. G. Böttger, and L. Feinendegen. 1992. Frontal lobe function in amyotrophic lateral sclerosis: a neuropsychologic and positron emission tomography study. Acta Neurol. Scand. 85:81-89.
66. Lulé, D., A. Kurt, R. Jürgens, J. Kassubek, V. Diekmann, E. Kraft, N. Neumann, A. C. Ludolph, N. Birbaumer, and S. Anders. 2005. Emotional responding in amyotrophic lateral sclerosis. J. Neurol.252:1517-1524.
67. Lulé, D., V. Diekmann, S. Anders, J. Kassubek, A. Kübler, A. C. Ludolph, and N. Birbaumer. 2007. Brain responses to emotional stimuli in patients with amyotrophic lateral sclerosis (ALS). J. Neurol.254:519-527.
68. Lule, D., V. Diekmann, H. Muller, J. Kassubek, A. C. Ludolph, and N. Birbaumer. 2010. Neuroimaging of multimodal sensory stimulation in amyotrophic lateral sclerosis. J. Neurol. Neurosurg. Psychiatry81:899-906.
69. Lutzenberger, W., N. Birbaumer, T. Elbert, B. Rockstroh, W. Bippus, R. Breidt. 1980. Self-regulation of slow cortical potentials in normal subjects and patients with frontal lobe lesions. Prog. Brain Res.54:427-430.
70. Lutzenberger, W., L. E. Roberts, and N. Birbaumer. 1993. Memory performance and area-specific self-regulation of slow cortical potentials: dual-task interference. Int. J. Psychophysiol.15:217-226.
71. Mantovan, M. C., L. Baggio, G. Dalla Barba, P. Smith, E. Pegoraro, G. Soraru', P. Bonometto, and C. Angelini. 2003. Memory deficits and retrieval processes in ALS. Eur. J. Neurol.10:221-227.
72. Martens, S. M. M., N. J. Hill, J. Farquhar, and B. Schölkopf. 2009. Overlap and refractory effects in a brain-computer interface speller based on the visual P300 event-related potential. J. Neural Eng.6:026003.
73. Massman, P. J., et al. 1996. Prevalence and correlates of neuropsychological deficits in amyotrophic lateral sclerosis. J. Neurol. Neurosurg. Psychiatry61:450-455.
74. McDonald, J. J., W. A. Teder-Salejarvi, and S. A. Hillyard. 2000. Involuntary orienting to sound improves visual perception. Nature407:906-908.
75. McFarland, D. J., L. A. Miner, T. M. Vaughan, and J. R. Wolpaw. 2000. Mu and beta rhythm topographies during motor imagery and actual movements. Brain Topogr.12:177-186.
76. Mohammadi, B., K. Kollewe, A. Samii, R. Dengler, and T. F. Münte. 2011. Functional neuroimaging at different disease stages reveals distinct phases of neuroplastic changes in amyotrophic lateral sclerosis. Hum. Brain Mapp.32:750-758.
77. Murphy, J. M., R. G. Henry, S. Langmore, J. H. Kramer, B. L. Miller, and C. Lomen-Hoerth. 2007. Continuum of frontal lobe impairment in amyotrophic lateral sclerosis. Arch. Neurol.64:530-534.
78. Neumann, M., D. M. Sampathu, L. K. Kwong, A. C. Truax, M. C. Micsenyi, T. T. Chou, J. Bruce, T. Schuck, M. Grossman, C. M. Clark, L. F. McCluskey, B. L. Miller, E. Masliah, I. R. Mackenzie, H. Feldman, W. Feiden, H. A. Kretzschmar, J. Q. Trojanowski, and V. M. Lee. 2006. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science314:130-133.
79. Newsom-Davis, I. C., S. Abrahams, L. H. Goldstein, and P. N. Leigh. 1999. The emotional lability questionnaire: a new measure of emotional lability in amyotrophic lateral sclerosis. J. Neurol. Sci.169:22-25.
80. Niedermeyer, E. 2004. The normal EEG of the waking adult. Pp. 149-173inE. Niedermeyer and F. Lopes da Silva, eds. Electroencephalography: basic principles, clinical applications and related fields. Lippincott Williams and Wilkins, Baltimore.
81. Nijboer, F., E. W. Sellers, J. Mellinger, M. A. Jordan, T. Matuz, A. Furdea, S. Halder, U. Mochty, D. J. Krusienski, T. M. Vaughan, J. R. Wolpaw, N. Birbaumer, and A. Kübler. 2008. A P300-based brain-computer interface for people with amyotrophic lateral sclerosis. Clin. Neurophysiol.119:1909-1916.
82. Nijboer, F., N. Birbaumer, and A. Kubler. 2010. The influence of psychological state and motivation on brain-computer interface performance in patients with amyotrophic lateral sclerosis - a longitudinal study. Front Neurosci. 4:1-13.
83. Norani, N. A. M., W. Mansor, and L. Y. Khuan. 2010. A review of signal processing in brain computer interface system. Pp. 443-449inConference on Biomedical Engineering and Sciences (IECBES), 2010 IEEE EMBS, Buenos Aires, Argentina.
84. Ogawa, T., H. Tanaka, and K. Hirata. 2009. Cognitive deficits in amyotrophic lateral sclerosis evaluated by event-related potentials. Clin. Neurophysiol.120:659-664.
85. Papps, B., S. Abrahams, P. Wicks, P. N. Leigh, and L. H. Goldstein. 2005. Changes in memory for emotional material in amyotrophic lateral sclerosis (ALS). Neuropsychologia43:1107-1114.
86. Paulus, K. S., I. Magnano, M. R. Piras, M. A. Solinas, G. Solinas, G. F. Sau, and I. Aiello. 2002. Visual and auditory event-related potentials in sporadic amyotrophic lateral sclerosis. Clin. Neurophysiol.113:853-861.
87. Perego, P., A. C. Turconi, G. Andreoni, L. Maggi, E. Beretta, S. Parini, and C. Gagliardi. 2011. Cognitive ability assessment by brain-computer interface validation of a new assessment method for cognitive abilities. J. Neurosci. Methods201:239-250.
88. Perelmouter, J., and N. Birbaumer. 2000. A binary spelling interface with random errors. IEEE Trans. Rehabil. Eng.8:227-232.
89. Perelmouter, J., B. Kotchoubey, A. Kübler, and N. Birbaumer. 1999. Language support program for thought-translation devices. Automedica18:67-84.
90. Pfurtscheller, G. 1999. EEG event-related desynchronization (ERD) and event-related synchronization (ERS). Pp. 958-967inE. Niedermeyer and F. L. d. Silva, eds. Electroencephalography: basic principles, clinical applications and related fields. Williams and Wilkins, Baltimore.
91. Pfurtscheller, G., and C. Neuper. 1997. Motor imagery activates primary sensorimotor area in humans. Neurosci. Lett.239:65-68.
92. Pfurtscheller, G., et al. 2000. Current trends in Graz Brain-Computer Interface (BCI) research. IEEE Trans. Rehabil. Eng.8:216-219.
93. Phukan, J., N. P. Pender, and O. Hardiman. 2007. Cognitive impairment in amyotrophic lateral sclerosis. Lancet Neurol. 6:994-1003.
94. Phukan, J., M. Elamin, P. Bede, N. Jordan, L. Gallagher, S. Byrne, C. Lynch, N. Pender, and O. Hardiman. 2011. The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study. J. Neurol. Neurosurg. Psychiatry83(1):102-108.
95. Pinkhardt, E. H., R. Jürgens, W. Becker, M. Mölle, J. Born, A. C. Ludolph, and H. Schreiber. 2008. Signs of impaired selective attention in patients with amyotrophic lateral sclerosis. J. Neurol.255:532-538.
96. Polich, J. 2004. Clinical application of the P300 event-related brain potential. Phys. Med. Rehabil. Clin. N. Am.15:133-161.
97. Polich, J. 2007. Updating P300: an integrative theory of P3a and P3b. Clin. Neurophysiol.118:2128-2148.
98. Polich, J., and H. K. McIsaac. 1994. Comparison of auditory P300 habituation from active and passive conditions. Int. J. Psychophysiol.17:25-34.
99. Rakowicz, W. P., and J. R. Hodges. 1998. Dementia and aphasia in motor neuron disease: an underrecognised association?J. Neurol. Neurosurg. Psychiatry65:881-889.
100. Ringholz, G. M., S. H. Appel, M. Bradshaw, N. A. Cooke, D. M. Mosnik, and P. E. Schulz. 2005. Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology65:586-590.
101. Rippon, G. A., N. Scarmeas, P. H. Gordon, P. L. Murphy, S. M. Albert, H. Mitsumoto, K. Marder, L. P. Rowland, and Y. Stern. 2006. An observational study of cognitive impairment in amyotrophic lateral sclerosis. Arch. Neurol.63:345-352.
102. Robinson, K. M., S. C. Lacey, P. Grugan, G. Glosser, M. Grossman, and L. F. McCluskey. 2006. Cognitive functioning in sporadic amyotrophic lateral sclerosis: a six month longitudinal study. J. Neurol. Neurosurg. Psychiatry77:668-670.
103. Sach, M., G. Winkler, and V. Glauche. 2004. Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis. Brain127:340-350.
104. Sage, C. A., R. R. Peeters, A. Görner, W. Robberecht, and S. Sunaert. 2007. Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis. Neuroimage34:486-499.
105. Salvaris, M., and F. Sepulveda. 2009. Perceptual errors in the Farwell and Donchin matrix speller. Pp. 275-278inProceesings of the 4th International IEEE EMBS Conference on Neural Engineering. Antalya, Turkey.
106. Schneider, F., B. Rockstroh, H. Heimann, W. Lutzenberger, R. Mattes, T. Elbert, N. Birbaumer, and M. Bartels. 1992. Self-regulation of slow cortical potentials in psychiatric patients: schizophrenia. Biofeedback Self-Regul.17:277-292.
107. Schreiber, H., T. Gaigalat, U. Wiedemuth-Catrinescu, M. Graf, I. Uttner, R. Muche, and A. C. Ludolph. 2005. Cognitive function in bulbar- and spinal-onset amyotrophic lateral sclerosis. A longitudinal study in 52 patients. J. Neurol.252:772-781.
108. Sellers, E. W., and E. Donchin. 2006. A P300-based brain-computer interface: initial tests by ALS patients. Clin. Neurophysiol.117:538-548.
109. Sellers, E. W., A. Kubler, and E. Donchin. 2006. Brain-computer interface research at the University of South Florida Cognitive Psychophysiology Laboratory: the P300 Speller. IEEE Trans. Neural Syst. Rehabil. Eng.14:221-224.
110. Senda, J., M. Ito, and H. Watanabe. 2009. Correlation between pyramidal tract degeneration and widespread white matter involvement in amyotrophic lateral sclerosis: a study with tractography and diffusion-tensor imaging. Amyotroph. Lateral Scler.10:288-294.
111. Serby, H., E. Yom-Tov, and G. F. Inbar. 2005. An improved P300-based brain-computer interface. IEEE Trans. Neural Syst. Rehabil. Eng.13:89-98.
112. Silvoni, S., C. Volpato, M. Cavinato, M. Marchetti, K. Priftis, A. Merico, P. Tonin, K. Koutsikos, F. Beverina, and F. Piccione. 2009. P300-based brain-computer interface communication: evaluation and follow-up in amyotrophic lateral sclerosis. Front Neurosci.3:60.
113. Squires, N. K., E. Donchin, K. C. Squires, and S. Grossberg. 1977. Bisensory stimulation: inferring decision-related processes from P300 component. J. Exp. Psychol. Hum. Percept Perform.3:299-315.
114. Srinivasan, R., P. L. Nunez, and R. B. Silberstein. 1998. Spatial filtering and neocortical dynamics: estimates of EEG coherence. IEEE Trans. Biomed. Eng.45:814-826.
115. Stanton, B. R., V. C. Williams, P. N. Leigh, S. C. Williams, C. R. Blain, J. M. Jarosz, and A. Simmons. 2007. Altered cortical activation during a motor task in ALS. Evidence for involvement of central pathways. J. Neurol.254:1260-1267.
116. Strong, M., and J. Rosenfeld. 2003. Amyotrophic lateral sclerosis: a review of current concepts. Amyotroph. Lateral Scler. Other Motor Neuron Disord.4:136-143.
117. Strong, M. J., G. M. Grace, J. B. Orange, and H. A. Leeper. 1996. Cognition, language, and speech in amyotrophic lateral sclerosis: a review. J. Clin. Exp. Neuropsychol.18:291-303.
118. Strong, M. J., G. M. Grace, J. B. Orange, H. A. Leeper, R. S. Menon, C. Aere. 1999. A prospective study of cognitive impairment in ALS. Neurology53:1665-1670.
119. Strong, M. J., W. Yang, W. L. Strong, C. Leystra-Lantz, H. Jaffe, and H. C. Pant. 2006. Tau protein hyperphosphorylation in sporadic ALS with cognitive impairment. Neurology66:1770-1771.
120. Sutter, E. E. 1992. The brain response interface: communication through visually-induced electrical brain responses. J. Microcomput. Appl.15:31-45.
121. Sutton, S., M. Braren, J. Zubin, and E. R. John. 1965. Evoked-potential correlates of stimulus uncertainty. Science150:1187-1188.
122. Talbot, P. R., P. J. Goulding, J. J. Lloyd, J. S. Snowden, D. Neary, and H. J. Testa. 1995. Inter-relation between "classic" motor neuron disease and frontotemporal dementia: neuropsychological and single photon emission computed tomography study. J. Neurol Neurosurg. Psychiatry58:541-547.
123. Tan, D., and A. Nijholt. 2010. Brain-computer interface and human-computer interaction. Brain-computer interfaces: applying our minds to human-computer interaction, 2010. Springer-Verlag, London.
124. Tanaka, M., S. Kondo, S. Hirai, X. Sun, T. Yamagishi, and K. Okamoto. 1993. Cerebral blood flow and oxygen metabolism in progressive dementia associated with amyotrophic lateral sclerosis. J. Neurol. Sci.120:22-28.
125. Teder-Sälejärvi, W. A., J. J. McDonald, F. Di Russo, and S. A. Hillyard. 2002. An analysis of audio-visual crossmodal integration by means of event-related potential (ERP) recordings. Brain Res. Cogn. Brain Res.14:106-114.
126. Teplan, N. 2002. Fundamentals of EEG measurement. Meas. Sci. Rev.2(2):1-11.
127. Treder, M. S., and B. Blankertz. 2010. (C)overt attention and visual speller design in an ERP-based brain-computer interface. Behav. Brain Funct.6:28.
128. Tsermentseli, S., P. N. Leigh, and L. H. Goldstein. 2012. The anatomy of cognitive impairment in amyotrophic lateral sclerosis: more than frontal lobe dysfunction. Cortex48:166-182.
129. Turner, M., A. Hammers, and J. Allsop. 2007. Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis. Amyotroph. Lateral Scler.9:238-248.
130. Vaughan, T. M., D. J. McFarland, G. Schalk, W. A. Sarnacki, D. J. Krusienski, E. W. Sellers, and J. R. Wolpaw. 2006. The Wadsworth BCI Research and Development Program: at home with BCI. IEEE Trans. Neural Syst. Rehabil. Eng.14:229-233.
131. Verleger, R. 2008. P3b: towards some decision about memory. Clin. Neurophysiol.119: 968-970.
132. Vidal, J. J. 1977. Real-time detection of brain events in EEG. Biol. Signal Process. Analysis65:633-664.
133. Vieregge, P., B. Wauschkuhn, I. Heberlein, J. Hagenah, and R. Verleger. 1999. Selective attention is impaired in amyotrophic lateral sclerosis-a study of event-related EEG potentials. Brain Res. Cogn. Brain Res.8:27-35.
134. Wolpaw, J. R., and D. J. McFarland. 2004. Control of a two-dimensional movement signal by a noninvasive brain-computer interface in humans. Proc. Natl. Acad. Sci. U.S.A.101:17849-17854.
135. Wolpaw, J. R., D. J. McFarland, G. W. Neat, and C. A. Forneris. 1991. An EEG-based brain-computer interface for cursor control. Electroencephalogr. Clin. Neurophysiol.78:252-259.
136. Wolpaw, J. R., N. Birbaumer, W. J. Heetderks, D. J. McFarland, P. H. Peckham, G. Schalk, E. Donchin, L. A. Quatrano, C. J. Robinson, and T. M. Vaughan. 2000. Brain-computer interface technology: a review of the first international meeting. IEEE Trans. Rehabil. Eng.8:164-173.
137. Wolpaw, J. R., N. Birbaumer, D. J. McFarland, G. Pfurtscheller, and T. M. Vaughan. 2002. Brain-computer interfaces for communication and control. Clin. Neurophysiol.113:767-791.