PECAM-1-targeted micron-sized particles of iron oxide as mri contrast agent for detection of vascular remodeling after cerebral ischemia

Contrast Media and Molecular Imaging

Volumn 8, Issue 5, 2013, Pages 393-401

  Deddens, Lisette H ^a   van Tilborg, Geralda A F ^a   van der Toorn, Annette ^a   de Vries, Helga E ^b   Dijkhuizen, Rick M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Angiogenesis; Molecular imaging; MPIO; MRI; PECAM 1; Stroke

Indexed keywords

CD31 ANTIGEN; CELL ADHESION MOLECULE; FLUORESCENT DYE; IRON OXIDE; MESSENGER RNA; MICRON SIZED PARTICLES OF IRON OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; BRAIN ISCHEMIA; BRAIN TISSUE; CELL LABELING; CONTRAST ENHANCEMENT; CONTROLLED STUDY; ENDOTHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEAR INFRARED SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; ANTIGENS, CD31; BRAIN ISCHEMIA; CONTRAST MEDIA; FERRIC COMPOUNDS; GENE EXPRESSION REGULATION; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE ANGIOGRAPHY; MICE; MOLECULAR IMAGING; NEOVASCULARIZATION, PHYSIOLOGIC; PARTICLE SIZE; STROKE;

EID: 84879023725     PISSN: 15554309     EISSN: 15554317     Source Type: Journal    
DOI: 10.1002/cmmi.1536     Document Type: Article

References (42)

1. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. New Engl J Med 2008; 359(13): 1317-1329.
2. Cramer SC. Repairing the human brain after stroke. II. Restorative therapies. Ann Neurol 2008; 63(5): 549-560.
3. Zhang ZG, Chopp M. Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol 2009; 8(5): 491-500.
4. Cramer SC. Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery. Ann Neurol 2008; 63(3): 272-287.
5. Xiong Y, Mahmood A, Chopp M. Angiogenesis, neurogenesis and brain recovery of function following injury. Curr Opin Invest Drugs 2010; 11(3): 298-308.
6. Arai K, Jin G, Navaratna D, Lo EH. Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J 2009; 276(17): 4644-4652.
7. Yanev P, Dijkhuizen RM. In vivo imaging of neurovascular remodeling after stroke. Stroke 2012; 43(12): 3436-3441.
8. Beck H, Plate KH. Angiogenesis after cerebral ischemia. Acta Neuropathol 2009; 117(5): 481-496.
9. Hayashi T, Deguchi K, Nagotani S, Zhang H, Sehara Y, Tsuchiya A, Abe K. Cerebral ischemia and angiogenesis. Curr Neurovasc Res 2006; 3(2): 119-129.
10. Krupinski J, Kaluza J, Kumar P, Kumar S, Wang JM. Role of angiogenesis in patients with cerebral ischemic stroke. Stroke 1994; 25(9): 1794-1798.
11. Slevin M, Kumar P, Gaffney J, Kumar S, Krupinski J. Can angiogenesis be exploited to improve stroke outcome? Mechanisms and therapeutic potential. Clin Sci (Lond) 2006; 111(3): 171-183.
12. Liman TG, Endres M. New vessels after stroke: postischemic neovascularization and regeneration. Cerebrovasc Dis 2012; 33(5): 492-499.
13. Baird AE, Warach S. Magnetic resonance imaging of acute stroke. J Cereb Blood Flow Metab 1998; 18(6): 583-609.
14. Dijkhuizen RM, Nicolay K. Magnetic resonance imaging in experimental models of brain disorders. J Cereb Blood Flow Metab 2003; 23(12): 1383-1402.
15. Farr TD, Wegener S. Use of magnetic resonance imaging to predict outcome after stroke: a review of experimental and clinical evidence. J Cereb Blood Flow Metab 2010; 30(4): 703-717.
16. Barbier EL, Lamalle L, Decorps M. Methodology of brain perfusion imaging. J Magn Reson Imaging 2001; 13(4): 496-520.
17. Seevinck PR, Deddens LH, Dijkhuizen RM. Magnetic resonance imaging of brain angiogenesis after stroke. Angiogenesis 2010; 13(2): 101-111.
18. Calamante F, Thomas DL, Pell GS, Wiersma J, Turner R. Measuring cerebral blood flow using magnetic resonance imaging techniques. J Cereb Blood Flow Metab 1999; 19(7): 701-735.
19. Wu EX, Tang H, Jensen JH. Applications of ultrasmall superparamagnetic iron oxide contrast agents in the MR study of animal models. NMR Biomed 2004; 17(7): 478-483.
20. Deddens LH, Van Tilborg GA, Mulder WJ, De Vries HE, Dijkhuizen RM. Imaging neuroinflammation after stroke: current status of cellular and molecular MRI strategies. Cerebrovasc Dis 2012; 33(4): 392-402.
21. Marti HJ, Bernaudin M, Bellail A, Schoch H, Euler M, Petit E, Risau W. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol 2000; 156(3): 965-976.
22. Matsuda F, Sakakima H, Yoshida Y. The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats. Acta Physiol (Oxf) 2011; 201(2): 275-287.
23. Ohab JJ, Fleming S, Blesch A, Carmichael ST. A neurovascular niche for neurogenesis after stroke. J Neurosci 2006; 26(50): 13007-13016.
24. Mora-Lee S, Sirerol-Piquer MS, Gutierrez-Perez M, Lopez T, Casado-Nieto M, Jauquicoam C, Abizanda G, Romaguera-Ros M, Gomez-Pinedo U, Prosper F, Garcia-Verdugo JM. Histological and ultrastructural comparison of cauterization and thrombosis stroke models in immune-deficient mice. J Inflamm (Lond) 2011; 8(1): 28.
25. Gertz K, Kronenberg G, Kalin RE, Baldinger T, Werner C, Balkaya M, Eom GD, Hellmann-Regen J, Krober J, Miller KR, Lindauer U, Laufs U, Dirnagl U, Heppner FL, Endres M. Essential role of interleukin-6 in post-stroke angiogenesis. Brain 2012; 135(Pt 6): 1964-1980.
26. Mulder WJ, Strijkers GJ, Habets JW, Bleeker EJ, Van der Schaft DW, Storm G, Koning GA, Griffioen AW, Nicolay K. MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle. FASEB J 2005; 19(14): 2008-2010.
27. Jarzyna PA, Deddens LH, Kann BH, Ramachandran S, Calcagno C, Chen W, Gianella A, Dijkhuizen RM, Griffioen AW, Fayad ZA, Mulder WJ. Tumor angiogenesis phenotyping by nanoparticle-facilitated magnetic resonance and near-infrared fluorescence molecular imaging. Neoplasia 2012; 14(10): 964-973.
28. Cai K, Caruthers SD, Huang W, Williams TA, Zhang H, Wickline SA, Lanza GM, Winter PM. MR molecular imaging of aortic angiogenesis. JACC Cardiovasc Imag 2010; 3(8): 824-832.
29. Oostendorp M, Douma K, Wagenaar A, Slenter JM, Hackeng TM, van Zandvoort MA, Post MJ, Backes WH. Molecular magnetic resonance imaging of myocardial angiogenesis after acute myocardial infarction. Circulation 2010; 121(6): 775-783.
30. Xiao L, Zhang Y, Yang Z, Xu Y, Kundu B, Chordia MD, Pan D. Synthesis of PECAM-1-specific 64Cu PET imaging agent: evaluation of myocardial infarction caused by ischemia-reperfusion injury in mouse. Bioorg Med Chem Lett 2012; 22(12): 4144-4147.
31. Caruthers SD, Winter PM, Wickline SA, Lanza GM, Keupp J. MR molecular imaging of angiogenesis using targeted perfluorocarbon nanoparticles. Medicamundi 2010; 54(2): 5-13.
32. Cai W, Guzman R, Hsu AR, Wang H, Chen K, Sun G, Gera A, Choi R, Bliss T, He L, Li ZB, Maag AL, Hori N, Zhao H, Moseley M, Steinberg GK, Chen X. Positron emission tomography imaging of poststroke angiogenesis. Stroke 2009; 40(1): 270-277.
33. Hoyte LC, Brooks KJ, Nagel S, Akhtar A, Chen R, Mardiguian S, McAteer MA, Anthony DC, Choudhury RP, Buchan AM, Sibson NR. Molecular magnetic resonance imaging of acute vascular cell adhesion molecule-1 expression in a mouse model of cerebral ischemia. J Cereb Blood Flow Metab 2010; 30(6): 1178-1187.
34. Deddens LH, Van Tilborg GA, Van der Toorn A, Paulis LE, Strijkers GJ, Storm G, Mulder WJ, De Vries HE, Dijkhuizen RM. Micron-sized particles of iron oxide and gadolinium-containing liposomes as targeted contrast agent for molecular MRI of neuroinflammation after stroke: a comparative study. Proc Intl Soc Mag Reson Med 20: 1627P.
35. Newman PJ. The biology of PECAM-1. J Clin Invest 1997; 100(11 suppl): S25-29.
36. Yang Y, Yanasak N, Schumacher A, Hu TC. Temporal and noninvasive monitoring of inflammatory-cell infiltration to myocardial infarction sites using micrometer-sized iron oxide particles. Magn Reson Med 2010; 63(1): 33-40.
37. Ye Q, Wu YL, Foley LM, Hitchens TK, Eytan DF, Shirwan H, Ho C. Longitudinal tracking of recipient macrophages in a rat chronic cardiac allograft rejection model with noninvasive magnetic resonance imaging using micrometer-sized paramagnetic iron oxide particles. Circulation 2008; 118(2): 149-156.
38. Chacko AM, Nayak M, Greineder CF, Delisser HM, Muzykantov VR. Collaborative enhancement of antibody binding to distinct PECAM-1 epitopes modulates endothelial targeting. PLoS One 2012; 7(4): e34958.
39. Wagner EF, Risau W. Oncogenes in the study of endothelial cell growth and differentiation. Semin Cancer Biol 1994; 5(2): 137-145.
40. Perls M. Nachweis von Eisenoxyd in gewissen Pigmenten. Virchows Arch 1867; 39(1): 42-48.
41. Schroeter M, Saleh A, Wiedermann D, Hoehn M, Jander S. Histochemical detection of ultrasmall superparamagnetic iron oxide (USPIO) contrast medium uptake in experimental brain ischemia. Magn Reson Med 2004; 52(2): 403-406.
42. Hata R, Mies G, Wiessner C, Fritze K, Hesselbarth D, Brinker G, Hossmann KA. A reproducible model of middle cerebral artery occlusion in mice: hemodynamic, biochemical, and magnetic resonance imaging. J Cereb Blood Flow Metab 1998; 18(4): 367-375.