Paromomycin-loaded albumin microspheres: Efficacy and stability studies

Drug Testing and Analysis

Volumn 5, Issue 6, 2013, Pages 468-473

  Khan, Wahid ^a   Kumar, Rajendra ^b   Singh, Sukhvinder ^b   Arora, Sunil Kumar ^b   Kumar, Neeraj ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Amastigote; Leishmaniasis; Microspheres; Paromomycin; Promastigote

Indexed keywords

CONTROLLED DRUG DELIVERY; CROSSLINKING; MACROPHAGES; PARTICLE SIZE; STABILITY; TARGETED DRUG DELIVERY;

AMASTIGOTE; CONDITION; LEISHMANIASIS; MEAN PARTICLE SIZE; PAROMOMYCIN; PASSIVE TARGETING; PROMASTIGOTES; SPRAY-DRYING METHOD; STABILITY STUDY; VISCERAL LEISHMANIASIS;

MICROSPHERES;

ALBUMIN; MICROSPHERE; PAROMOMYCIN;

AMASTIGOTE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; HOST CELL; HUMIDITY; IN VITRO STUDY; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROMASTIGOTE; ROOM TEMPERATURE; SPRAY DRYING; VISCERAL LEISHMANIASIS;

EID: 84879011885     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.389     Document Type: Article

References (24)

1. S. Das, W. Khan, S. Mohsin, N. Kumar Miltefosine loaded albumin microparticles for treatment of visceral leishmaniasis: formulation development and in vitro evaluation. Polym. Adv. Technol. 2011, 22, 172.
2. H.W. Murray, J.D. Berman, C.R. Davies, N.G. Saravia Advances in leishmaniasis Lancet 2005, 366, 1561.
3. J. Mishra, A. Saxena, S. Singh Chemotherapy of leishmaniasis: past, present and future. Curr. Med. Chem. 2007, 14, 1153.
4. S.L. Croft, S. Sundar, A.H. Fairlamb Drug resistance in leishmaniasis. Clin. Microbiol. Rev. 2006, 19, 111.
5. E.L. Romero, M.J. Morilla Drug delivery systems against leishmaniasis? Still an open question. Expert Opin. Drug Del. 2008, 5, 805.
6. S. Sundar, T.K. Jha, C.P. Thakur, P.K. Sinha, S.K. Bhattacharya Injectable paromomycin for visceral leishmaniasis in India. N. Engl. J. Med. 2007, 356, 2571.
7. R.N. Davidson, M. den Boer, K. Ritmeijer Paromomycin. Trans. R. Soc. Trop. Med. Hyg. 2008, 103, 653.
8. C.P. Thakur Tetany in kala azar patients treated with paromomycin. Indian J. Med. Res. 2008, 127, 489.
9. W. Khan, N. Kumar Characterization, thermal stability studies, and analytical method development of Paromomycin for formulation development. Drug Test. Anal. 2011, 3, 363.
10. W. Khan, N. Kumar Drug targeting to macrophages using paromomycin-loaded albumin microspheres for treatment of visceral leishmaniasis: an in vitro evaluation. J. Drug Target. 2011, 19, 239.
11. W. Khan, S.S. Sharma, N. Kumar Bioanalytical method development, pharmacokinetics and toxicity studies of paromomycin and paromomycin loaded in albumin microspheres. Drug Test. Anal. (in press) 2011.
12. A.F. Yapel Jr. Albumin microspheres: heat and chemical stabilization. Method Enzymol. 1985, 112, 1.
13. F.Q. Li, J.H. Hu, B. Lu, H. Yao, W.G. Zhang Ciprofloxacin-loaded bovine serum albumin microspheres: preparation and drug-release in vitro. J. Microencapsul. 2001, 18, 825.
14. H. Nettey, D. Haswani, C.W. Oettinger, M.J. D'Souza Formulation and testing of vancomycin loaded albumin microspheres prepared by spray-drying. J. Microencapsul. 2006, 23, 632.
15. I.P. Singh, S.K. Jain, A. Kaur, S. Singh, R. Kumar, P. Garg, et al. Synthesis and antileishmanial activity of piperoyl-amino acid conjugates. Eur. J. Med. Chem. 2010, 45, 3439.
16. L. Ordonez-Gutierrez, R. Espada-Fernandez, M.A. Dea-Ayuela, J.J. Torrado, F. Bolas-Fernandez, J.M. Alunda In vitro effect of new formulations of amphotericin B on amastigote and promastigote forms of Leishmania infantum. Int. J. Antimicrob. Ag. 2007, 30, 325.
17. A. Nan, S.L. Croft, V. Yardley, H. Ghandehari Targetable water-soluble polymer-drug conjugates for the treatment of visceral leishmaniasis. J. Control. Release 2004, 94, 115.
18. K.D. Manandhar, T.P. Yadav, V.K. Prajapati, S. Kumar, M. Rai, A. Dube, et al. Antileishmanial activity of nano-amphotericin B deoxycholate. J. Antimicrob. Chemother. 2008, 62, 376.
19. G. Pujals, J.M. Sune-Negre, P. Perez, E. Garcia, M. Portus, J.R. Tico, et al. In vitro evaluation of the effectiveness and cytotoxicity of meglumine antimoniate microspheres produced by spray drying against Leishmania infantum. Parasitol. Res. 2008, 102, 1243.
20. P.M. Dandagi, V.S. Mastiholimath, M.B. Patil, M.K. Gupta Biodegradable microparticulate system of captopril. Int. J. Pharm. 2006, 307, 83.
21. A.G.A. Coombes, V. Breeze, W. Lin, T. Gray, K.G. Parker, T. Parker Lactic acid-stabilised albumin for microsphere formulation and biomedical coatings. Biomaterials 2001, 22, 1.
22. F. Chellat, Y. Merhi, A. Moreau, L. Yahia Therapeutic potential of nanoparticulate systems for macrophage targeting. Biomaterials 2005, 26, 7260.
23. R.A. Neal, S.L. Croft An in vitro system for determining the activity of compounds against the intracellular amastigote form of Leishmania donovani. J. Antimicrob. Chemother. 1984, 14, 463.
24. R.A. Neal, S. Allen, N. McCoy, P. Olliaro, S.L. Croft The sensitivity of Leishmania species to aminosidine. J. Antimicrob. Chemother. 1995, 35, 577.