Tetany in kala azar patients treated with paromomycin

Indian Journal of Medical Research

Volumn 127, Issue 5, 2008, Pages 489-493

  Thakur, C P ^a,b  

^a Balaji Utthan Sansthan   (India)

^b NONE   (India)

Author keywords

Intravenous calcium gluconate; Kala azar; Paromomycin; Pharmacovigilance; Tetany

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; CALCIUM; DEXAMETHASONE; GLUCONATE CALCIUM; HEMOGLOBIN; MILTEFOSINE; PAROMOMYCIN;

ABDOMINAL DISTENSION; ADOLESCENT; ARTICLE; CASE REPORT; CHILD; CHILL; CLINICAL EXAMINATION; EAR DISEASE; EARLY DIAGNOSIS; EARLY INTERVENTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE SEDIMENTATION RATE; EVENING DOSAGE; FEMALE; FEVER; HEPATOMEGALY; HUMAN; HYPOCALCEMIA; INDIA; KIDNEY DISEASE; KIDNEY TUBULE DAMAGE; LEISHMANIA; LEISHMANIASIS; LEUKOCYTE COUNT; MALE; MORNING DOSAGE; SPLEEN BIOPSY; SYMPTOM; TETANY; THROMBOCYTE COUNT; TREATMENT DURATION; TREATMENT OUTCOME;

ADOLESCENT; ANTI-BACTERIAL AGENTS; CALCIUM; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; LEISHMANIASIS, VISCERAL; MALE; PAROMOMYCIN; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TETANY;

EID: 51349152776     PISSN: 09715916     EISSN: 09715916     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Neal RA. The effect of antibiotics of the neomycin group on experimental cutaneous leishmaniasis. Ann Trop Med Parasitol 1968; 62: 54-62.
2. Thakur CP, Olliaro P, Ghothoskar S, Bhowmick S, Choudhary BK, Prasad S, et al. Treatment of visceral leishmaniasis (kalaazar) with aminosidine (paromomycin) antimonial combinations, a pilot study in Bihar, India. Trans R Soc Trop Med Hyg 1992; 86: 615-6.
3. Chunge CN, Owate J, Pamba HO, Donno L. Treatment of visceral leishmaniasis in Kenya by aminosidine alone or combined with sodium stibogluconate. Trans R Soc Trop Med Hyg 1990; 84: 221-5.
4. Thakur CP, Bhowmick S, Dolfi L, Olliaro P. Aminosidine plus sodium stibogluconate for the treatment of Indian kala-azar: a randomized dose finding clinical trial. Trans R Soc Trop Med Hyg 1995; 89: 219-23.
5. Dutta M, Ghosh TK. Review of current status of leishmaniasis epidemiology. In: Mahajan RC, editor. Proceedings of the Indo-U.K. Workshop on leishmaniasis. New Delhi: Indian Council of Medical Research; 1983. p. 97-102.
6. Thakur CP. Report of Expert Team on Kala-azar Programme Assessment. New Delhi: Directorate of National Malaria Eradication Programme; 1991.
7. Lira R, Sundar S, Makharia A, Keeney R, Gam A, Saraiva E, et al. Evidence that the high incidence of treatment failure in kala-azar is due to the emergence of antimony resistant strains of Leishmania donovani. J Infect Dis 1999; 180: 564-7.
8. Jha TK, Olliaro P, Thakur CP, Kanyok TP, Singhania BL, Singh IJ, et al. Randomised controlled trial of aminosidine (paromomycin) v sodium stibogluconate for treating visceral leishmaniasis in North Bihar, India. BMJ 1998; 316: 1200-5.
9. Thakur CP, Kanyok TP, Pandey AK, Sinha GP, Messick C, Olliaro P. Treatment of visceral leishmaniasis with injectable paromomycin (aminosidine). An open-label randomized phase II clinical study. Trans R Soc Trop Med Hyg 2000; 99: 432-3.
10. Sundar S, Jha TK, Thakur CP, Sinha PK, Bhattacharya SK. Injectable paromomycin for visceral leishmaniasis in India. N Engl J Med 2007; 356: 2571-81.
11. Medline Plus drug information (http://www.nlm.nih.gov/medlineplus/ druginfo/uspdi/202027.html) -Aminoglycosides (Systemic) accessed on 1.7.2007.
12. Davidson's principles and practice of medicine, 20th ed. Boon NA, College NR, Walker BR, Hunter JAA, editors. Edinburgh: Churchill Livingstone; 2006.
13. Elliott C, Newman N, Madan A. Gentamicin effects on urinary electrolyte excretion in healthy subjects. Clin Pharmacol Ther 2000; 67: 16-21.
14. Bar RS, Wilson HE, Mazzaferri EL, Hypomagnesemic hypocalcemia secondary to renal magnesium wasting. Ann Intern Med 1975; 82: 646-9.
15. Giapros VI, Papadimitriou FK, Andronikou SK. Tubular disorders in low birth weight neonates after prolonged antibiotic treatment. Neonatology 2007; 91: 140-4.
16. Tugay S, Bircan Z, Caglayan C, Arisoy AE, Gokalp AS. Acute effects of gentamicin on glomerular and tubular functions in preterm neonates. Pediatr Nephrol 2006; 21: 1389-92.
17. Malacarne P, Bergamasco S, Donadio C. Nephrotoxicity due to combination antibiotic therapy with vancomycin and amonoglycosides in septic critically ill patients. Chemotherapy 2006; 52: 178-84.
18. Crawford LM, Campbell DL, Harvey T. Hypocalcemic effect of aminoglycoside antibiotics in the dairy cow. Can J Comp Med 1977; 41: 251-6.
19. Kelnar CJ, Hypomagnesaemic tetany associated with prolonged treatment with aminoglycosides. Br Med J 1986; 292: 1017.
20. Schentag JL, Juskow WJ. Gentamycin persistence in the body. Lancet 1977; i: 486.
21. Adams JP, Conway SP, Wilson C. Hypomagnesaemic tetany associated with repeated courses of intravenous tobramycin in a patient with cystic fibrosis. Respir Med 1998: 92: 602-4.
22. Davies SV, Murray JA. Amphotericin B, aminoglycosides, and hypomagnesaemic tetagy. BMJ Res Med 1986; 292: 1395-6.