Chondrogenic capacity and alterations in hyaluronan synthesis of cultured human osteoarthritic chondrocytes

Biochemical and Biophysical Research Communications

Volumn 435, Issue 4, 2013, Pages 733-739

  Ono, Yohei ^a,b   Sakai, Tadahiro ^a   Hiraiwa, Hideki ^a   Hamada, Takashi ^a   Omachi, Takaaki ^a   Nakashima, Motoshige ^a   Ishizuka, Shinya ^a   Matsukawa, Tetsuya ^a   Knudson, Warren ^b   Knudson, Cheryl B ^b   Ishiguro, Naoki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Autologous chondrocyte implantation; Chondrocyte; Differentiation; Hyaluronan; Hyaluronan synthase; Osteoarthritis

Indexed keywords

AGGRECAN; COLLAGEN TYPE 2; HYALURONIC ACID; MESSENGER RNA; SYNTHETASE; TRANSCRIPTION FACTOR SOX9;

ADULT; AGED; ARTICLE; CARTILAGE CELL; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL EXPANSION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE PRODUCT; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; MARKER GENE; MOLECULAR SIZE; MONOLAYER CULTURE; OSTEOARTHRITIC CHONDROCYTE; PHENOTYPE; PRIORITY JOURNAL; SYNTHESIS;

AGED; AGED, 80 AND OVER; CELLS, CULTURED; CHONDROCYTES; CHONDROGENESIS; FEMALE; HUMANS; HYALURONIC ACID; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE;

EID: 84879002194     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.05.052     Document Type: Article

References (22)

1. Knudson C.B., Knudson W. Hyaluronan and CD44: modulators of chondrocyte metabolism. Clin. Orthop. Relat. Res. 2004, 427:S152-S162.
2. Knudson W., Loeser R.F. CD44 and integrin matrix receptors participate in cartilage homeostasis. Cell. Mol. Life Sci. 2002, 59:36-44.
3. Nishida Y., Knudson C.B., Nietfeld J.J., et al. Antisense inhibition of hyaluronan synthase-2 in human articular chondrocytes inhibits proteoglycan retention and matrix assembly. J. Biol. Chem. 1999, 274:21893-21899.
4. Takahashi N., Knudson C.B., Thankamony S., et al. Induction of CD44 cleavage in articular chondrocytes. Arthritis Rheum. 2010, 62:1338-1348.
5. Akiyama H., Chaboissier M.C., Martin J.F., et al. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002, 16:2813-2828.
6. Itano N., Sawai T., Yoshida M., et al. Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J. Biol. Chem. 1999, 274:25085-25092.
7. Brittberg M., Lindahl A., Nilsson A., et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N. Engl. J. Med. 1994, 331:889-895.
8. Yang K.G., Saris D.B., Geuze R.E., et al. Altered in vitro chondrogenic properties of chondrocytes harvested from unaffected cartilage in osteoarthritic joints. Osteoarthritis Cartilage 2006, 14:561-570.
9. Dehne T., Karlsson C., Ringe J., et al. Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation. Arthritis Res. Ther. 2009, 11:R133.
10. Benya P.D., Shaffer J.D. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 1982, 30:215-224.
11. Lin Z., Fitzgerald J.B., Xu J., et al. Gene expression profiles of human chondrocytes during passaged monolayer cultivation. J. Orthop. Res. 2008, 26:1230-1237.
12. Embry J.J., Knudson W. G1 domain of aggrecan cointernalizes with hyaluronan via a CD44-mediated mechanism in bovine articular chondrocytes. Arthritis Rheum. 2003, 48:3431-3441.
13. Sekiya I., Vuoristo J.T., Larson B.L., Prockop D.J. In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proc. Natl. Acad. Sci. USA 2002, 99:4397-4402.
14. Mort J.S., Roughley P.J. Measurement of glycosaminoglycan release from cartilage explants. Methods Mol. Med. 2007, 135:201-209.
15. Lauer M.E., Mukhopadhyay D., Fulop C., et al. Primary murine airway smooth muscle cells exposed to poly(I, C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix. J. Biol. Chem. 2009, 284:5299-5312.
16. Kuroda T., Matsumoto T., Mifune Y., et al. Therapeutic strategy of third-generation autologous chondrocyte implantation for osteoarthritis. Ups. J. Med. Sci. 2011, 116:107-114.
17. Acosta C.A., Izal I., Ripalda P., et al. Gene expression and proliferation analysis in young, aged, and osteoarthritic sheep chondrocytes effect of growth factor treatment. J. Orthop. Res. 2006, 24:2087-2094.
18. von der Mark K., Kirsch T., Nerlich A., et al. Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy. Arthritis Rheum. 1992, 35:806-811.
19. Albrecht C., Schlegel W., Eckl P., et al. Alterations in CD44 isoforms and HAS expression in human articular chondrocytes during the de- and re-differentiation processes. Int. J. Mol. Med. 2009, 23:253-259.
20. Oguchi T., Ishiguro N. Differential stimulation of three forms of hyaluronan synthase by TGF-beta, IL-1beta, and TNF-alpha. Connect. Tissue Res. 2004, 45:197-205.
21. Recklies A.D., White C., Melching L., Roughley P.J. Differential regulation and expression of hyaluronan synthases in human articular chondrocytes, synovial cells and osteosarcoma cells. Biochem. J. 2001, 354:17-24.
22. Spicer A.P., McDonald J.A. Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family. J. Biol. Chem. 1998, 273:1923-1932.