G1 Domain of Aggrecan Cointernalizes with Hyaluronan Via a CD44-Mediated Mechanism in Bovine Articular Chondrocytes

Arthritis and Rheumatism

Volumn 48, Issue 12, 2003, Pages 3431-3441

  Embry, Jennifer J ^a   Knudson, Warren ^a  

^a RUSH MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; BIOTIN; FLUORESCEIN ISOTHIOCYANATE; HERMES ANTIGEN; HYALURONIC ACID; MONOMER; PROTEOGLYCAN; TRYPSIN;

AGGRECAN G1 DOMAIN; ANIMAL CELL; ARTICLE; BIOTINYLATION; CARTILAGE CELL; CATTLE; CELL STRAIN COS7; CELL SURFACE; CELL VACUOLE; CONTROLLED STUDY; ENDOCYTOSIS; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION;

AGGRECANS; ANIMALS; ANTIGENS, CD44; BIOTIN; CARTILAGE, ARTICULAR; CATTLE; CHONDROCYTES; COS CELLS; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HYALURONIC ACID; LECTINS, C-TYPE; MALE; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEOGLYCANS; TRANSFECTION;

EID: 0346220063     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.11323     Document Type: Article

References (29)

1. Kuettner KE. Osteoarthritis: cartilage integrity and homeostasis. In: Klippel JH, Dieppe PA, editors. Rheumatology. St. Louis: Mosby-Year Book Europe; 1994. p. 6.1-16.
2. Fosang AJ, Last K, Maciewicz RA. Aggrecan is degraded by matrix metalloproteinases in human arthritis: evidence that matrix metalloproteinase and aggrecanase activities can be independent. J Clin Invest 1996;98:2292-9.
3. Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, et al. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science 1999;284:1664-6.
4. Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, et al. Aggrecan degradation in human cartilage: evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. J Clin Invest 1997;100:93-105.
5. Morales TI, Hascall VC. Correlated metabolism of proteoglycans and hyaluronic acid in bovine cartilage organ cultures. J Biol Chem 1988;263:3632-8.
6. Ng CK, Handley CJ, Preston BN, Robinson HC. The extracellular processing and catabolism of hyaluronan in cultured adult articular cartilage explants. Arch Biochem Biophys 1992;298:70-9.
7. Fosang AJ, Last K, Stanton H, Weeks DB, Campbell IK, Hardingham TE, et al. Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants. J Biol Chem 2000;275:33027-37.
8. Hua Q, Knudson CB, Knudson W. Internalization of hyaluronan by chondrocytes occurs via receptor-mediated endocytosis. J Cell Sci 1993;106:365-75.
9. Chow G, Knudson CB, Homandberg G, Knudson W. Increased expression of CD44 in bovine articular chondrocytes by catabolic cellular mediators. J Biol Chem 1995;270:27734-41.
10. Nishida Y, D'Souza AL, Thonar EJ, Knudson W. Stimulation of hyaluronan metabolism by interleukin-1α in human articular cartilage. Arthritis Rheum 2000;43:1315-26.
11. Jiang H, Peterson RS, Wang W, Bartnik E, Knudson CB, Knudson W. A requirement for the CD44 cytoplasmic domain for hyaluronan binding, pericellular matrix assembly, and receptor-mediated endocytosis in COS-7 cells. J Biol Chem 2002;277:10531-8.
12. Nishida Y, Knudson CB, Kuettner KE, Knudson W. Osteogenic protein-1 promotes the synthesis and retention of extracellular matrix within bovine articular cartilage and chondrocyte cultures. Osteoarthritis Cartilage 2000;8:127-36.
13. Li XQ, Thonar EJ, Knudson W. Accumulation of hyaluronate in human lung carcinoma as measured by a new hyaluronate ELISA. Connect Tissue Res 1989;19:243-53.
14. Aguiar DJ, Knudson W, Knudson CB. Internalization of the hyaluronan receptor CD44 by chondrocytes. Exp Cell Res 1999;252:292-302.
15. Knudson W, Bartnik E, Knudson CB. Assembly of pericellular matrices by COS-7 cells transfected with CD44 lymphocyte-homing receptor genes. Proc Natl Acad Sci U S A 1993;90:4003-7.
16. Thonar EJ, Sweet MB, Immelman AR, Lyons G. Hyaluronate in articular cartilage: age-related changes. Calcif Tissue Res 1978;26:19-21.
17. Holmes MW, Bayliss MT, Muir H. Hyaluronic acid in human articular cartilage: age-related changes in content and size. Biochem J 1988;250:435-41.
18. Dingle JT. Mechanisms of cartilage destruction and repair: the outlook for therapeutic interventions. Cliniguide Rheum 1993;3:1-5.
19. Martel-Pelletier J. Pathophysiology of osteoarthritis. Osteoarthritis Cartilage 1998;6:374-6.
20. Lark MW, Gordy JT, Weidner JR, Ayala J, Kimura JH, Williams HR, et al. Cell-mediated catabolism of aggrecan: evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain. J Biol Chem 1995;270:2550-6.
21. Ilic MZ, Handley CJ, Robinson HC, Mok MT. Mechanism of catabolism of aggrecan by articular cartilage. Arch Biochem Biophys 1992;294:115-22.
22. Kresse H, Glossl J. Glycosaminoglycan degradation. In: Meister A, editor. Advances in Enzymology. New York: Wiley; 1987. p. 217-311.
23. Evanko SP, Wight TN. Intracellular localization of hyaluronan in proliferating cells. J Histochem Cytochem 1999;47:1331-42.
24. Roughley PJ, White RJ, Poole AR. Identification of a hyaluronic acid-binding protein that interferes with the preparation of high-buoyant-density proteoglycan aggregates from adult human articular cartilage. Biochem J 1985;231:129-38.
25. Maroudas A, Bayliss MT, Uchitel-Kaushansky N, Schneiderman R, Gilav E. Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age. Arch Biochem Biophys 1998;350:61-71.
26. Roughley PJ, White RJ, Poole AR, Mort JS. The inability to prepare high-buoyant-density proteoglycan aggregates from extracts of normal adult human articular cartilage. Biochem J 1984;221:637-44.
27. Underhill CB, Nguyen HA, Shizari M, Culty M. CD44 positive macrophages take up hyaluronan during lung development. Dev Biol 1993;155:324-36.
28. Culty M, Shizari M, Thompson EW, Underhill CB. Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44: correlation with invasive potential. J Cell Physiol 1994;160:275-86.
29. Tammi R, Rilla K, Pienimaki JP, MacCallum DK, Hogg M, Luukkonen M, et al. Hyaluronan enters keratinocytes by a novel endocytic route for catabolism. J Biol Chem 2001;276:35111-22.