Structural alterations in chronic lymphocytic leukaemia. Cytogenetic and FISH analysis

Hematological Oncology

Volumn 31, Issue 2, 2013, Pages 79-87

  Travella, Ana ^a   Ripollés, Lorena ^d   Aventin, Anna ^e   Rodríguez, Andrea ^b   Bezares, Raimundo F ^c   Caballín, María R ^d   Slavutsky, Irma ^a  

^a ACADEMIA NACIONAL DE MEDICINA   (Argentina)

^b INST DE INVEST HEMATOLOGICAS   (Argentina)

^c Hospital General De Agudos Teodoro Alvarez   (Argentina)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^e HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

Chronic lymphocytic leukaemia; Complex karyotypes; Cytogenetics; FISH

Indexed keywords

BETA 2 MICROGLOBULIN;

ADULT; AGED; ARTICLE; CHROMOSOME 13; CHROMOSOME 6; CHROMOSOME 8; CHROMOSOME 8P; CHROMOSOME DELETION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; INTERPHASE; KARYOTYPE; LEUKOCYTE COUNT; MALE; METAPHASE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; STRUCTURAL CHROMOSOME ABERRATION; THROMBOCYTE COUNT;

EID: 84878980175     PISSN: 02780232     EISSN: 10991069     Source Type: Journal    
DOI: 10.1002/hon.2025     Document Type: Article

References (33)

1. Chiorazzi N, Rai KR, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med 2005; 352: 804-815.
2. Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS. Clinical staging of chronic lymphocytic leukemia. Blood 1975; 46: 219-234.
3. Binet JL, Lepoprier M, Dighiero G, et al. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer 1977; 40: 855-864.
4. Binet JL, Caligaris-Cappio F, Catovsky D, et al. International Workshop on Chronic Lymphocytic Leukemia (IWCLL). Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia. Blood 2006; 107: 859-861.
5. Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukaemia. Blood 1999; 94: 1840-1847.
6. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukaemia. Blood 1999; 94: 1848-1854.
7. Döhner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910-1916.
8. Kröber A, Seiler T, Benner A, et al. VH mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 2002; 100: 1410-1416.
9. Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003; 348: 1764-1775.
10. Mayr C, Speicher MR, Kofler DM, et al. Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia. Blood 2006; 107: 742-751.
11. H status and immunophenotyping. Leukemia 2007; 21: 2442-2451.
12. Beà S, López-Guillermo A, Ribas M, et al. Genetic imbalances in progressed B-cell chronic lymphocytic leukemia and transformed large-cell lymphoma (Richter's syndrome). Am J Pathol 2002; 161: 957-968.
13. Forconi F, Rinaldi A, Kwee I, et al. Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukemia with 17p deletion. Br J Haematol 2008; 143: 532-536.
14. O'Malley DP, Giudice C, Chang AS, et al. Comparison of array comparative genomic hybridization (aCGH) to FISH and cytogenetics in prognostic evaluation of chronic lymphocytic leukemia. Int J Lab Hematol 2011; 33: 238-244.
15. Müller-Hermelink HK, Monserrat E, Catovsky D, Campo E, Harris NL, Stein H. Chronic lymphocytic leukemia/small lymphocytic lymphoma. In WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds). IARC: Lyon, 2008; 180-182.
16. H status, and CD38 expression. Blood 2006; 108: 3152-3160.
17. ISCN. In An International System for Human Cytogenetic Nomenclature. Shaffer LG, Slovak ML, Campbell LJ (eds). Karger: Basel, 2009.
18. Rigolin GM, Cibien F, Martinelli S, et al. Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia with "normal" FISH: correlations with clinicobiologic parameters. Blood 2012; 119: 2310-2313.
19. Mittelman F, Johansson B, Mertens F (eds). Mitelman Database of Chromosome Aberration and Gene Fusions in Cancer, 2012. Available from: http://cgap.nci.nih.gov/Chromosomes/Mitelman.
20. Cerretini R, Chena C, Giere I, et al. Structural aberrations of chromosomes 17 and 12 in chronic B-cell disorders. Eur J Haematol 2003; 71: 433-438.
21. Busson-Le Coniat M, Salomon-Nguyen F, Dastugue N, et al. Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations. Leukemia 1999; 13: 1975-1981.
22. Grubor V, Krasnitz A, Troge JE, et al. Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA). Blood 2009; 113: 1294-1303.
23. Gunnarsson R, Mansouri L, Isaksson A, et al. Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia. Haematologica 2011; 96: 1161-1169.
24. Pittaluga S, Verhoef G, Criel A, et al. "Small" B-cell non-Hodgkin's lymphomas with splenomegaly at presentation are either mantle cell lymphoma or marginal zone cell lymphoma. A study based on histology, cytology, immunohistochemistry, and cytogenetic analysis. Am J Surg Pathol 1996; 20: 211-223.
25. Giglio S, Calvari V, Gregato G, et al. Heterozygous submicroscopic inversions involving olfactory receptor-gene clusters mediate the recurrent t(4;8)(p16;p23) translocation. Am J Hum Genet 2002; 71: 276-285.
26. Lalonde JP, Lim R, Ingley E, et al. HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor. J Biol Chem 2004; 279: 8181-8189.
27. Rubio-Moscardo F, Blesa D, Mestre C, et al. Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes. Blood 2005; 106: 214-222.
28. Parker H, Rose-Zerillo MJJ, Parker A, et al. 13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia. Leukemia 2011; 25: 489-497.
29. Van Den Neste E, Robin V, Francart J, et al. Chromosomal translocations independently predict treatment failure, treatment-free survival and overall survival in B-cell chronic lymphocytic leukemia patients treated with cladribine. Leukemia 2007; 21: 1715-1722.
30. Cavazzini F, Cuneo A, de Angeli C, et al. Abnormalities of chromosomes 1p34-36, 4p16, 4q35, 9q11-32 and +7 represent novel recurrent cytogenetic rearrangements in chronic lymphocytic leukemia. Leuk Lymphoma 2004; 45: 1197-1203.
31. Van Dyke DL, Shanafelt TD, Call TG, et al. A comprehensive evaluation of the prognostic significance of 13q deletions in patients with B-chronic lymphocytic leukaemia. Br J Haematol 2010; 148: 544-550.
32. Tam CS, Shanafelt TD, Wierda WG, et al. De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M.D. Anderson and Mayo Clinic experience. Blood 2009; 114: 957-964.
33. Koski T, Karhu R, Visakorpi T, Vilpo L, Knuutila S, Vilpo J. Complex chromosomal aberrations in chronic lymphocytic leukemia are associated with cellular drug and irradiation resistance. Eur J Haematol 2000; 65: 32-39.