Towards a More Precise Serological Diagnosis of Human Tegumentary Leishmaniasis Using Leishmania Recombinant Proteins

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Souza, Ana Paula ^a   Soto, Manuel ^b   Costa, Jackson M L ^a   Boaventura, Viviane S ^a,c   de Oliveira, Camila I ^a,c,d   Cristal, Juqueline R ^a   Barral Netto, Manoel ^a,c,d   Barral, Aldina ^a,c,d  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^d Instituto Nacional de Ciencia e Tecnologia de Investigacao em Imunologia iii INCT   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; RECOMBINANT HEAT SHOCK PROTEIN 70; RECOMBINANT HISTONE H2A; RECOMBINANT HISTONE H2B; RECOMBINANT HISTONE H3; RECOMBINANT HISTONE H4; RECOMBINANT KMP11; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CHAGAS DISEASE; CHILD; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SPECIFICITY; FEMALE; HUMAN; IMMUNOREACTIVITY; LEPROSY; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PROTEIN CROSS LINKING; PROTEIN PURIFICATION; RECEIVER OPERATING CHARACTERISTIC; SCHOOL CHILD; SEROLOGY; SKIN LEISHMANIASIS; SYSTEMIC LUPUS ERYTHEMATOSUS; TEGUMENTARY LEISHMANIASIS; TUBERCULOSIS;

ENZYME-LINKED IMMUNOSORBENT ASSAY; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LEISHMANIA; LEISHMANIASIS; OLIGONUCLEOTIDES; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; ROC CURVE; SEROLOGIC TESTS; STATISTICS, NONPARAMETRIC;

LEISHMANIA INFANTUM;

EID: 84878945709     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066110     Document Type: Article

References (61)

1. de Oliveira CI, Bafica A, Oliveira F, Favali CBF, Correa T, et al. (2003) Clinical utility of polymerase chain reaction-based detection of Leishmania in the diagnosis of American cutaneous leishmaniasis. Clin Infect Dis 37: e149-e153 doi:10.1086/379610.
2. Oliveira JGS, Novais FO, de Oliveira CI, da Cruz Junior AC, Campos LF, et al. (2005) Polymerase chain reaction (PCR) is highly sensitive for diagnosis of mucosal leishmaniasis. Acta Trop 94: 55-59 doi:10.1016/j.actatropica.2004.12.003.
3. Fagundes A, Schubach A, Paula CCde, Bogio A, Antonio LdeF, et al. (2010) Evaluation of polymerase chain reaction in the routine diagnosis for tegumentary leishmaniasis in a referral centre. Mem Inst Oswaldo Cruz 105: 109-112.
4. Boggild AK, Valencia BM, Espinosa D, Veland N, Ramos AP, et al. (2010) Detection and species identification of Leishmania DNA from filter paper lesion impressions for patients with American cutaneous leishmaniasis. Clin Infect Dis 50: e1-e6 doi:10.1086/648730.
5. Weigle KA, Labrada LA, Lozano C, Santrich C, Barker DC, (2002) PCR-based diagnosis of acute and chronic cutaneous leishmaniasis caused by Leishmania (Viannia). J Clin Microbiol 40: 601-606.
6. Weigle KA, de Dávalos M, Heredia P, Molineros R, Saravia NG, et al. (1987) Diagnosis of cutaneous and mucocutaneous leishmaniasis in Colombia: a comparison of seven methods. Am J Trop Med Hyg 36: 489-496.
7. Luz ZMP, Silva ARD, Silva FdeO, Caligiorne RB, Oliveira E, et al. (2009) Lesion aspirate culture for the diagnosis and isolation of Leishmania spp. from patients with cutaneous leishmaniasis. Mem Inst Oswaldo Cruz 104: 62-66.
8. Barral A, Almeida RP, de Jesus AR, Medeiros Neto E, Santos IA, et al. (1987) The relevance of characterizing Leishmania from cutaneous lesions. A simple approach for isolation. Mem Inst Oswaldo Cruz 82: 579 doi:10.1590/S0074-02761987000400018.
9. Anthony RL, Grogl M, Sacci JB, Ballou RW, (1987) Rapid detection of Leishmania amastigotes in fluid aspirates and biopsies of human tissues. Am J Trop Med Hyg 37: 271-276.
10. Lynch NR, Malavé C, Ifante RB, Modlin RL, Convit J, (1986) In situ detection of amastigotes in American cutaneous leishmaniasis, using monoclonal antibodies. Trans R Soc Trop Med Hyg 80: 6-9.
11. Lunedo SN, Thomaz-Soccol V, de Castro EA, Telles JEQ, (2011) Immunocytochemical and immunohistochemical methods as auxiliary techniques for histopathological diagnosis of cutaneous leishmaniasis. Acta Histochem doi:10.1016/j.acthis.2011.06.002.
12. Perinoto ÂC, Maki RM, Colhone MC, Santos FR, Migliaccio V, et al. (2010) Biosensors for efficient diagnosis of leishmaniasis: innovations in bioanalytics for a neglected disease. Anal Chem 82: 9763-9768 doi:10.1021/ac101920t.
13. Mabey D, Peeling RW, Ustianowski A, Perkins MD, (2004) Diagnostics for the developing world. Nat Rev Microbiol 2: 231-240 doi:10.1038/nrmicro841.
14. Goto H, Lindoso JAL, (2010) Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. Expert Rev Anti Infect Ther 8: 419-433 doi:10.1586/eri.10.19.
15. Roffi J, Dedet JP, Desjeux P, Garré MT, (1980) Detection of circulating antibodies in cutaneous leishmaniasis by enzyme-linked immunosorbent assay (ELISA). Am J Trop Med Hyg 29: 183-189.
16. Cataldo JI, de Queiroz Mello FC, Mouta-Confort E, de Fátima Madeira M, de Oliveira Schubach A, et al. (2010) Immunoenzymatic assay for the diagnosis of American tegumentary leishmaniasis using soluble and membrane-enriched fractions from infectious Leishmania (Viannia) braziliensis. J Clin Lab Anal 24: 289-294 doi:10.1002/jcla.20402.
17. Romero GAS, la Glória Orge Orge de M, de Farias Guerra MV, Paes MG, de Oliveira Macêdo V, et al. (2005) Antibody response in patients with cutaneous leishmaniasis infected by Leishmania (Viannia) braziliensis or Leishmania (Viannia) guyanensis in Brazil. Acta Trop 93: 49-56 doi:10.1016/j.actatropica.2004.09.005.
18. Guimarães MC, Celeste BJ, Corrales EM, Antunes CM, (1991) Comparison on the performance of Leishmania major-like and Leishmania braziliensis braziliensis as antigen for New World leishmaniasis IgG-immunofluorescence test. Rev Inst Med Trop Sao Paulo 33: 503-508.
19. Kalter DC, (1994) Laboratory tests for the diagnosis and evaluation of leishmaniasis. Dermatol Clin 12: 37-50.
20. Coelho EAF, Ramírez L, Costa MAF, Coelho VTS, Martins VT, et al. (2009) Specific Serodiagnosis of Canine Visceral Leishmaniasis Using Leishmania Species Ribosomal Protein Extracts. CLINICAL AND VACCINE IMMUNOLOGY 16: 1774-1780.
21. Kubar J, Fragaki K, (2005) Recombinant DNA-derived leishmania proteins: from the laboratory to the field. Lancet Infect Dis 5: 107-114 doi:10.1016/S1473-3099(05)01282-X.
22. Braz RFS, Nascimento ET, Martins DRA, Wilson ME, Pearson RD, et al. (2002) The sensitivity and specificity of Leishmania chagasi recombinant K39 antigen in the diagnosis of American visceral leishmaniasis and in differentiating active from subclinical infection. Am J Trop Med Hyg 67: 344-348.
23. Boarino A, Scalone A, Gradoni L, Ferroglio E, Vitale F, et al. (2005) Development of recombinant chimeric antigen expressing immunodominant B epitopes of Leishmania infantum for serodiagnosis of visceral leishmaniasis. Clin Diagn Lab Immunol 12: 647-653 doi:10.1128/CDLI.12.5.647-653.2005.
24. de Souza CM, Silva ED, Ano Bom APD, Bastos RC, Nascimento HJ, et al. (2012) Evaluation of an ELISA for canine leishmaniasis immunodiagnostic using recombinant proteins. Parasite Immunol 34: 1-7 doi:10.1111/j.1365-3024.2011.01334.x.
25. Montoya Y, Leon C, Talledo M, Nolasco O, Padilla C, et al. (1997) Recombinant antigens for specific and sensitive serodiagnosis of Latin American tegumentary leishmaniasis. Trans R Soc Trop Med Hyg 91: 674-676.
26. Iborra S, Soto M, Carrión J, Alonso C, Requena JM, (2004) Vaccination with a plasmid DNA cocktail encoding the nucleosomal histones of Leishmania confers protection against murine cutaneous leishmaniosis. Vaccine 22: 3865-3876 doi:10.1016/j.vaccine.2004.04.015.
27. Fuertes MA, Pérez JM, Soto M, López MC, Alonso C, (2001) Calcium-induced conformational changes in Leishmania infantum kinetoplastid membrane protein-11. J Biol Inorg Chem 6: 107-117.
28. Oliveira F, Bafica A, Rosato AB, Favali CBF, Costa JM, et al. (2011) Lesion size correlates with Leishmania antigen-stimulated TNF-levels in human cutaneous leishmaniasis. Am J Trop Med Hyg 85: 70-73 doi:10.4269/ajtmh.2011.10-0680.
29. Boaventura VS, Santos CS, Cardoso CR, de Andrade J, Santos Dos WLC, et al. (2010) Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines. Eur J Immunol 40: 2830-2836 doi:10.1002/eji.200940115.
30. Barral A, Honda E, Caldas A, Costa J, Vinhas V, et al. (2000) Human immune response to sand fly salivary gland antigens: a useful epidemiological marker? Am J Trop Med Hyg 62: 740-745.
31. Soto M, Requena JM, Quijada L, Alonso C, (1996) Specific serodiagnosis of human leishmaniasis with recombinant Leishmania P2 acidic ribosomal proteins. Clin Diagn Lab Immunol 3: 387-391.
32. Soto M, Requena JM, Quijada L, Alonso C, (1998) Multicomponent chimeric antigen for serodiagnosis of canine visceral leishmaniasis. J Clin Microbiol 36: 58-63.
33. de Souza Dias S, da Costa Pinheiro PH, Katz S, Santos dos MRM, Barbiéri CL, (2005) A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi suitable for serodiagnosis of American visceral leishmaniasis. Am J Trop Med Hyg 72: 126-132.
34. Rafati S, Hassani N, Taslimi Y, Movassagh H, Rochette A, et al. (2006) Amastin peptide-binding antibodies as biomarkers of active human visceral leishmaniasis. Clin Vaccine Immunol 13: 1104-1110 doi:10.1128/CVI.00188-06.
35. de Oliveira CI, Nascimento IP, Barral A, Soto M, Barral-Netto M, (2009) Challenges and perspectives in vaccination against leishmaniasis. Parasitol Int 58: 319-324 doi:10.1016/j.parint.2009.07.013.
36. Jones TC, Johnson WD, Barretto AC, Lago E, Badaró R, et al. (1987) Epidemiology of American cutaneous leishmaniasis due to Leishmania braziliensis braziliensis. J Infect Dis 156: 73-83.
37. Carvalho EM, Correia Filho D, Bacellar O, Almeida RP, Lessa H, et al. (1995) Characterization of the immune response in subjects with self-healing cutaneous leishmaniasis. Am J Trop Med Hyg 53: 273-277.
38. Saravia NG, Valderrama L, Labrada M, Holguín AF, Navas C, et al. (1989) The relationship of Leishmania braziliensis subspecies and immune response to disease expression in New World leishmaniasis. J Infect Dis 159: 725-735.
39. Ardeshir F, Flint JE, Richman SJ, Reese RT, (1987) A 75 kd merozoite surface protein of Plasmodium falciparum which is related to the 70 kd heat-shock proteins. EMBO J 6: 493-499.
40. Hedstrom R, Culpepper J, Harrison RA, Agabian N, Newport G, (1987) A major immunogen in Schistosoma mansoni infections is homologous to the heat-shock protein Hsp70. J Exp Med 165: 1430-1435.
41. Zügel U, Kaufmann SH, (1999) Immune response against heat shock proteins in infectious diseases. Immunobiology 201: 22-35.
42. de Andrade CR, Kirchhoff LV, Donelson JE, Otsu K, (1992) Recombinant Leishmania Hsp90 and Hsp70 are recognized by sera from visceral leishmaniasis patients but not Chagas' disease patients. J Clin Microbiol 30: 330-335.
43. Skeiky YA, Benson DR, Costa JL, Badaró R, Reed SG, (1997) Association of Leishmania heat shock protein 83 antigen and immunoglobulin G4 antibody titers in Brazilian patients with diffuse cutaneous leishmaniasis. Infect Immun 65: 5368-5370.
44. Celeste BJ, Angel SO, Castro LGM, Gidlund M, Goto H, (2004) Leishmania infantum heat shock protein 83 for the serodiagnosis of tegumentary leishmaniasis. Braz J Med Biol Res 37: 1591-1593.
45. Rey-Ladino JA, Joshi PB, Singh B, Gupta R, Reiner NE, (1997) Leishmania major: molecular cloning, sequencing, and expression of the heat shock protein 60 gene reveals unique carboxy terminal peptide sequences. Exp Parasitol 85: 249-263 doi:10.1006/expr.1996.4137.
46. Carrillo E, Crusat M, Nieto J, Chicharro C, Thomas MDC, et al. (2008) Immunogenicity of HSP-70, KMP-11 and PFR-2 leishmanial antigens in the experimental model of canine visceral leishmaniasis. Vaccine 26: 1902-1911 doi:10.1016/j.vaccine.2008.01.042.
47. Skeiky YA, Benson DR, Guderian JA, Whittle JA, Bacelar O, et al. (1995) Immune responses of leishmaniasis patients to heat shock proteins of Leishmania species and humans. Infect Immun 63: 4105-4114.
48. Zurita AI, Rodríguez J, Piñero JE, Pacheco R, Carmelo E, et al. (2003) Cloning and characterization of the Leishmania (Viannia) braziliensis Hsp70 gene. Diagnostic use of the C-terminal fragment rLb70(513-663). J Parasitol 89: 372-378 doi:[];10.1645/0022-3395(2003)089[0372:CACOTL]2.0.CO;2.
49. Quijada L, Requena JM, Soto M, Alonso C, (1998) Analysis of the antigenic properties of the L. infantum Hsp70: design of synthetic peptides for specific serodiagnosis of human leishmaniasis. Immunol Lett 63: 169-174.
50. Requena J, Alonso C, Soto M, (2000) Evolutionarily conserved proteins as prominent immunogens during Leishmania infections. Parasitol Today 16: 246-250.
51. Quijada L, Requena JM, Soto M, Alonso C, (1996) During canine viscero-cutaneous leishmaniasis the anti-Hsp70 antibodies are specifically elicited by the parasite protein. Parasitology 112 (Pt 3) (): 277-284.
52. Soto M, Requena JM, Quijada L, García M, Guzman F, et al. (1995) Mapping of the linear antigenic determinants from the Leishmania infantum histone H2A recognized by sera from dogs with leishmaniasis. Immunol Lett 48: 209-214 doi:10.1016/0165-2478(95)02473-5.
53. Soto M, Requena JM, Quijada L, Gomez LC, Guzman F, et al. (1996) Characterization of the antigenic determinants of the Leishmania infantum histone H3 recognized by antibodies elicited during canine visceral leishmaniasis. Clin Exp Immunol 106: 454-461.
54. Maalej IA, Chenik M, Louzir H, Ben Salah A, Bahloul C, et al. (2003) Comparative evaluation of ELISAs based on ten recombinant or purified Leishmania antigens for the serodiagnosis of Mediterranean visceral leishmaniasis. Am J Trop Med Hyg 68: 312-320.
55. Meddeb-Garnaoui A, Toumi A, Ghelis H, Mahjoub M, Louzir H, et al. (2010) Cellular and humoral responses induced by Leishmania histone H2B and its divergent and conserved parts in cutaneous and visceral leishmaniasis patients, respectively. Vaccine 28: 1881-1886 doi:10.1016/j.vaccine.2009.11.075.
56. Carmelo E, Martínez E, González AC, Piñero JE, Patarroyo ME, et al. (2002) Antigenicity of Leishmania braziliensis histone H1 during cutaneous leishmaniasis: localization of antigenic determinants. Clin Diagn Lab Immunol 9: 808-811.
57. de Carvalho LP, Soto M, Jerônimo S, Dondji B, Bacellar O, et al. (2003) Characterization of the immune response to Leishmania infantum recombinant antigens. Microbes Infect 5: 7-12.
58. Passos S, Carvalho LP, Orge G, Jeronimo SM, Bezerra G, et al. (2005) Recombinant leishmania antigens for serodiagnosis of visceral leishmaniasis. Clin Diagn Lab Immunol 12: 1164-1167 doi:10.1128/CDLI.12.10.1164-1167.2005.
59. Iniesta L, Fernández-Barredo S, Bulle B, Gómez MT, Piarroux R, et al. (2002) Diagnostic techniques to detect cryptic leishmaniasis in dogs. Clin Diagn Lab Immunol 9: 1137-1141.
60. Trujillo C, Ramírez R, Vélez ID, Berberich C, (1999) The humoral immune response to the kinetoplastid membrane protein-11 in patients with American leishmaniasis and Chagas disease: prevalence of IgG subclasses and mapping of epitopes. Immunol Lett 70: 203-209.
61. Ndao M, (2009) Diagnosis of parasitic diseases: old and new approaches. Interdiscip Perspect Infect Dis 2009: 278246 doi:10.1155/2009/278246.