Inhalable microparticles of nitric oxide donors induce phagosome maturation and kill Mycobacterium tuberculosis

Tuberculosis

Volumn 93, Issue 4, 2013, Pages 412-417

  Verma, Rahul Kumar ^a   Agrawal, Atul Kumar ^a   Singh, Amit Kumar ^a   Mohan, Mradul ^a   Gupta, Anuradha ^a   Gupta, Pushpa ^b   Gupta, Umesh Datta ^b   Misra, Amit ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b NATIONAL JALMA INSTITUTE FOR LEPROSY AND OTHER MYCOBACTERIAL DISEASES   (India)

Author keywords

DETA NO; Low dose aerosol infection; Macrophages; Microspheres; Pulmonary drug delivery

Indexed keywords

BACTERIAL DNA; DIETHYLENETRIAMINE NITRIC OXIDE ADDUCT; ISONIAZID; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; POLYLACTIDE; RIFABUTIN; UNCLASSIFIED DRUG;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERICIDAL ACTIVITY; CHEMOTHERAPY; COLONY FORMING UNIT; CONTROLLED STUDY; HISTOPATHOLOGY; LUNG; MACROPHAGE; MALE; MEMBRANE MICROPARTICLE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; SPRAY DRYING;

ADMINISTRATION, INHALATION; ANIMALS; ANTITUBERCULAR AGENTS; CELLS, CULTURED; COLONY COUNT, MICROBIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; DRUG THERAPY, COMBINATION; HUMANS; ISONIAZID; LUNG; MACROPHAGES; MALE; MICE; MICROSPHERES; MYCOBACTERIUM TUBERCULOSIS; NITRIC OXIDE DONORS; PHAGOSOMES; RIFABUTIN; SPLEEN; TUBERCULOSIS;

EID: 84878936028     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2013.02.012     Document Type: Article

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