Inhalable microparticles containing isoniazid and rifabutin target macrophages and 'stimulate the phagocyte' to achieve high efficacy

Indian Journal of Experimental Biology

Volumn 47, Issue 6 SPEC. ISS., 2009, Pages 469-474

  Yadav, Awadh Bihari ^a   Sharma, Rolee ^a,b   Muttil, Pavan ^a,c   Singh, Amit Kumar ^a   Verma, Rahul Kumar ^a   Mohan, Mradul ^a   Patel, Sanjay Kumar ^a   Misra, Amit ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b INTEGRAL UNIVERSITY   (India)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Inhalable microparticles; Isoniazid; Macrophage; Mycobacterium tuberculosis; Phagocyte; Rifabutin; TB

Indexed keywords

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

ISONIAZID; RIFABUTIN; TUBERCULOSTATIC AGENT;

ARTICLE; DNA FRAGMENTATION; DRUG EFFECT; HUMAN; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; MACROPHAGE; MACROPHAGE ACTIVATION; METABOLISM; MYCOBACTERIUM TUBERCULOSIS; PARTICLE SIZE; PHAGOCYTE; TUBERCULOSIS;

ADMINISTRATION, INHALATION; ANTITUBERCULAR AGENTS; DNA FRAGMENTATION; HUMANS; ISONIAZID; MACROPHAGE ACTIVATION; MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS; PARTICLE SIZE; PHAGOCYTES; RIFABUTIN; TUBERCULOSIS;

EID: 68249149640     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. (Pubitemid 47073457) Sharma R, Muttil P, Yadav A B et al., Uptake of inhalable microparticles affects defence responses of macrophages infected with Mycobacterium tuberculosis H37ra, J Antimicrob Chemother, 59 (3) (2007) 499.
2. (Pubitemid 47285721) Muttil P, Kaur J, Kumar K et al., Inhalable microparticles containing large payload of anti-tuberculosis drugs, Eur J Pharm Sci, 32 (2) (2007) 140.
3. (Pubitemid 32977245) Sharma R, Saxena D, Dwivedi A K et al. Inhalable microparticles containing drug combinations to target alveolar macrophages for treatment of pulmonary tuberculosis, Pharm Res, 18 (10) (2001) 1405.
4. Verma R K, Kaur J, Kumar K et al., Intracellular time course, pharmacokinetics, and biodistribution of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to mice, Antimicrob Agents Chemother, 52 (9) (2008) 3195.
5. Kaur J, Muttil P, Verma R K et al., A hand-held apparatus for "Nose-only" exposure of mice to inhalable microparticles as a dry powder inhalation targeting lung and airway macrophages, Eur J Pharm Sci, 34 (1) (2008) 56.
6. O'Hara P & Hickey A J, Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: manufacture and characterization, Pharm Res, 17 (8) (2000) 955.
7. (Pubitemid 32898818) Suarez S, O'Hara P, Kazantseva M et al., Airways delivery of rifampicin microparticles for the treatment of tuberculosis, J Antimicrob Chemother, 48 (3) (2001) 431.
8. (Pubitemid 47389237) Lu D, Garcia-Contreras L, Xu D et al., Poly (lactide-coglycolide) microspheres in respirable sizes enhance an in vitro t cell response to recombinant mycobacterium tuberculosis antigen 85b, Pharm Res, 24 (10) (2007) 1834.
9. (Pubitemid 32846326) Suarez S, O'Hara P, Kazantseva M et al., Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: screening in an infectious disease model, Pharm Res, 18 (9) (2001) 1315.
10. (Pubitemid 38829328) Makino K, Nakajima T, Shikamura M et al., efficient intracellular delivery of rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres: effects of molecular weight and composition of PLGA on release of rifampicin, Colloids Surf B Biointerfaces, 36 (1) (2004) 35.
11. (Pubitemid 38008419) Pandey R, Sharma A, Zahoor A et al., Poly (dl-lactide-coglycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis, J Antimicrob Chemother, 52 (6) (2003) 981.
12. Pandey R & Khuller G K, Antitubercular inhaled therapy: opportunities, progress and challenges, J Antimicrob Chemother, 55 (4) (2005) 430.
13. Bass D A, Parce J W, Dechatelet L R et al., Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation, J Immunol, 130 (4) (1983) 1910.
14. (Pubitemid 30482057) Zamzami N, Metivier D & Kroemer G, Quantitation of mitochondrial transmembrane potential in cells and in isolated mitochondria, Methods Enzymol, 322 (2000) 208.
15. (Pubitemid 40503658) Gan H, He X, Duan L et al., Enhancement of antimycobacterial activity of macrophages by stabilization of inner mitochondrial membrane potential, J Infect Dis, 191 (8) (2005) 1292.
16. Ma J, Chen T, Mandelin J et al., Regulation of macrophage activation, Cell Mol Life Sci, 60 (11) (2003) 2334.
17. Young D B, Stimulate the phagocytes, Tuberculosis (Edinb), 81 (4) (2001) 257.
18. Ng V H, Cox J S, Sousa A O et al., Role of katg catalaseperoxidase in mycobacterial pathogenesis: Countering the phagocyte oxidative burst, Mol Microbiol, 52 (5) (2004) 1291.
19. Barber G N, Host defense, viruses and apoptosis, Cell Death Differ, 8 (2) (2001) 113.
20. (Pubitemid 36026027) Riendeau C J & Kornfeld H, Thp-1 cell apoptosis in response to mycobacterial infection, Infect Immun, 71 (1) (2003) 254.
21. (Pubitemid 44264406) Lee J, Remold H G, Ieong M H et al., Macrophage apoptosis in response to high intracellular burden of mycobacterium tuberculosis is mediated by a novel caspase-independent pathway, J Immunol, 176 (7) (2006) 4267.
22. Rajavelu P & Das S D, A correlation between phagocytosis and apoptosis in thp-1 cells infected with prevalent strains of Mycobacterium tuberculosis Microbiol Immunol, 51 (2) (2007) 201.
23. (Pubitemid 37357705) Spira A, Carroll J D, Liu G et al., Apoptosis genes in human alveolar macrophages infected with virulent or attenuated mycobacterium tuberculosis: a pivotal role for tumor necrosis factor, Am JRespir Cell Mol Biol, 29 (5) (2003) 545.
24. (Pubitemid 30108758) Keane J, Remold H G & Kornfeld H, Virulent mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages, J Immunol, 164 (4) (2000) 2016.
25. (Pubitemid 41373935) Zhang J, Jiang R, Takayama H et al., Survival of virulent mycobacterium tuberculosis involves preventing apoptosis induced by Bcl-2 upregulation and release resulting from necrosis in J774 macrophages, Microbiol Immunol, 49 (9) (2005) 845.
26. (Pubitemid 28397084) Balcewicz-Sablinska M K, Keane J, Kornfeld H et al., Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-r2, resulting in inactivation of TNF-alpha, J Immunol, 161 (5) (1998) 2636.
27. Sly L M, Hingley-Wilson S M, Reiner N E et al., Survival of Mycobacterium tuberculosis in host macrophages involves resistance to apoptosis dependent upon induction of antiapoptotic Bcl-2 family member Mcl-1, J Immunol, 170 (1) (2003) 430.