Flow and consolidation properties of neem gum coprocessed with two pharmaceutical excipients

Powder Technology

Volumn 246, Issue , 2013, Pages 187-192

  Ogunjimi, Abayomi Tolulope ^a   Alebiowu, Gbenga ^a  

^a OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

Author keywords

Consolidation index; Coprocessing; Equivalent circle diameter; Irregularity; Neem gum

Indexed keywords

ANGLE OF INTERNAL FRICTION; CONSOLIDATION PROPERTIES; COPROCESSING; EQUIVALENT CIRCLE DIAMETER; EVALUATION PARAMETERS; IRREGULARITY; NEEM GUM; PHARMACEUTICAL EXCIPIENT;

ASPECT RATIO; STARCH;

SUGARS;

EXCIPIENT; LACTOSE; NEEM GUM; PLANT GUM; STARCH; UNCLASSIFIED DRUG;

ARTICLE; AZADIRACHTA INDICA; BULK DENSITY; FLOW RATE; FRICTION; MOISTURE; NONHUMAN; PARTICLE SIZE; PHYSICAL PARAMETERS; POWDER; WETTABILITY;

EID: 84878928057     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2013.04.051     Document Type: Article

References (26)

1. Shivanand P., Sprockel O.L. Compaction behavior of cellulose polymers. Powder Technology 1992, 69:177-184.
2. Prescott J., Barnum R. On powder flowability. Pharmaceutical Technology 2000, 24:60-84.
3. Thalberg K., Lindholm D., Axelsson A. Comparison of different flowability tests for powders for inhalation. Powder Technology 2006, 146:206-213.
4. Hedge R., Rheingold J.L., Welch S., Rhodes C.T. Studies of powder flow using a recording powder flowmeter and measurement of the dynamic angle of repose. Journal of Pharmaceutical Sciences 1985, 74:11-15.
5. Mullarney M., Hancock B., Carlson G., Ladipo D., Langdon B. The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets. International Journal of Pharmaceutics 2003, 257:227-236.
6. Kaye B.H. Characterizing the flowability of a powder using the concepts of fractal geometry and chaos theory. Particle & Particle System Characterization 1997, 14:53-66.
7. Faqih A., Alexander A., Muzzio F., Tomassone M.S. A method for predicting hopper flow characteristics of pharmaceutical powders. Chemical Engineering Science 2007, 62:1536-1542.
8. Hoffmann A.C., Finkers H.J., Seegers J.A. Relationships between particle properties and bulk behaviour for some industrial powders. Particle & Particle System Characterization 1996, 13:354-361.
9. Nachaegari S.K., Bansal A.K. Coprocessed excipients for solid dosage forms. Pharmaceutical Technology 2004, 28(1):52-64.
10. Ogunjimi A.T., Alebiowu G. A quantitative study of the influence of coprocessing of binders on the mechanical properties of paracetamol tablets. Brazilian Journal of Pharmaceutical Sciences 2010, 46(2):205-212.
11. Patel R.P., Bhavsar M. Directly compressible materials via co-processing. International Journal of PharmTech Research 2009, 1(3):745-753.
12. Adetogun G.E., Alebiowu G. Influence of Delonix regia seed gum on the compressional characteristics of paracetamol tablet formulation. Journal of Drug Delivery Science and Technology Paris 2007, 17(6):443-445.
13. A. Bodhmage, Correlation between physical properties and flowability indicators for fine powders. M.Sc. Thesis, Saskatchewan University, Canada. (2006) (unpublished).
14. British Standard 1460 1970, British Standard Institution, London.
15. Nyqvist H. Saturated salt solutions for maintaining specified relative humidities. International Journal of Pharmaceutical Technology and Product Manufacture 1983, 4:47-48.
16. Adetogun G.E., Alebiowu G., Taiwo B.J., Adeyemi I.O. Toxicological, physicochemical and compressional properties of Delonix regia seed gum. Nigerian Journal of Pharmaceutical Research 2009, 7:28-39.
17. Neumann B.S., Bean H.S., Becket A.H., Carless J.E. Advances in Pharmaceutical Sciences 1967, volume 2. Academic Press.
18. Wu C.Y., Ruddy O., Bentham A.C., Best S.M., Elliot J.A. Modelling the mechanical behavior of pharmaceutical powders during compaction. Powder Technology 2005, 152:107-117.
19. Carr R.L. Flow properties of granules. Chemical Engineering 1965, 72:163-166.
20. Plinke M.E., Leitch D., Loffler F. Cohesion in granular materials. Bulk Solids Handling 1994, 14:101-106.
21. Varthalis S., Pilpel N. Anomalies in some properties of powder mixtures. Journal of Pharmacy and Pharmacology 1976, 28:415-419.
22. Okore V.C. A preliminary evaluation of Dika fat-treated talc as a glidant for model granulations. West African Journal of Pharmacy 1999, 13(2):30-33.
23. Fitzpatrick J., Barringer S.A., Iqbal T. Flow property measurements of food powders and sensitivity of Jenike's hopper design methodology to the measured values. Journal of Food Engineering 2004, 61:399-405.
24. Shotton E., Obiorah B.A. Effect of physical properties on compression characteristics. Journal of Pharmaceutical Sciences 1975, 64:1213-1215.
25. De Boer A.H., Vromans H., Lerk C.F., Bolhuis G.K., Kussendrager K.D., Bosch H. Studies on tableting properties of lactose. III. The consolidation behavior of sieve fractions of crystalline α-lactose monohydrate. Pharmaceutisch Weekblad Scientific Edition 1986, 8(1986):145-150.
26. Sameh A., Firas A., Gabriele B. Investigating the effect of particle size and shape on high speed tableting through radial die-wall pressure monitoring. International Journal of Pharmaceutics 2011, 413:29-35.