Evaluation of an aqueous-ethanolic extract from Rosmarinus officinalis (Rosemary) for its activity on the hormonal and cellular function of testes in adult male rat

Iranian Journal of Pharmaceutical Research

Volumn 12, Issue 2, 2013, Pages 445-451

  Heidari Vala, Hamed ^a   Hariry, Reza Ebrahimi ^b   Sadeghi, Mohammad Reza ^a   Akhondi, Mohammad Mehdi ^a   Novin, Marefat Ghaffari ^c   Heidari, Mahnaz ^a,c  

^a AVICENNA RESEARCH INSTITUTE   (Iran)

^b GAZI UNIVERSITY   (Turkey)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Extract; Rat; Rosmarinus officinalis; Sperm; Testosterone

Indexed keywords

FOLLITROPIN; LUTEINIZING HORMONE; ROSMARINUS OFFICINALIS EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD SAMPLING; BODY WEIGHT; CELL FUNCTION; CHEMOLUMINESCENCE; CONTROLLED STUDY; MALE; NONHUMAN; PHASE CONTRAST MICROSCOPY; PROSTATE VENTRAL LOBE; RAT; SEMINAL VESICLE; SPERMATOGENESIS; SPERMATOGONIUM; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS; TESTOSTERONE BLOOD LEVEL; VAS DEFERENS;

EID: 84878910098     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Stefanovits-Bányai E, Tulok M, Hegedûs A, Renner C and Szöllôsi Varga I, Antioxidant effect of various rosemary (Rosmarinus officinalis L.) clones+, Acta Biologica Szegediensis. (2003) 47: 111-113.
2. Gruenwald J, Brendler T, Jaenicke C and Mehta M, PDR for Herbal Medicines, Medical Economics Company. (2000) 645-646.
3. Frankel E.N, Huang S.W, Aeschbach R and Prior E, Antioxidant activity of a rosemary extract and its constituents, carnosic acid, carnosol, and rosmarinic acid, in bulk oil and oil-in-water emulsion. J. Agricultural and Food Chemistry. (1996) 44: 131-135.
4. Lamaison JL, Petitjean-Freytet C and Carnat A, Medicinal Lamiaceae with antioxidant properties, a potential source of rosmarinic acid. Pharm. Acta. Helv. (1991) 66: 185-8.
5. Bernardes WA, Lucarini R, Tozatti M, Souza M, Andrade Silva M, da Silva Filho AA, Martins CHG, Miller Crotti, AE, Pauletti PM, GROPPO M and Cunha WR, Antimicrobial Activity of Rosmarinus officinalis against Oral Pathogens: Relevance of Carnosic Acid and Carnosol. Chemistry and Biodiversity. (2010) 7: 1835-1840.
6. Nolkemper S, Reichling J, Stentzin FC, Carle R and Achnitzler P, Antiviral effect of aqueous extracts from species of the Lamiaceas family against Herpes simplex virus type 1 and type 2 in-vitro. Planta Med. (2006) 72: 1378-1382.
7. Christensen P, Stryhn H and Hansen C, Discrepancies in the determination of sperm concentration using Bürker-Türk, Thoma and Makler counting chambers. Theriogenology. (2005) 63: 992-1003.
8. Flamini G, Cioni PL, Morelli I, Macchia M and Ceccarini L, Main agronomic-productive characteristics of two ecotypes of Rosmarinus officinalis L. and chemical composition of their essential oils. J. Agricultural and Food Chemistry. (2002) 50: 3512-3517.
9. Backleh M, Leupold G and Parlar H, Rapid quantitative enrichment of carnosic acid from rosemary (Rosmarinus officinalis L.) by isoelectric focused adsorptive bubble chromatography. J. Agricultural and Food Chemistry. (2003) 51: 1297-1301.
10. Offord EA, Gautier JC, Avanti O, Scaletta C, Runge F, Kramer K and Applegate LA, Photoprotective potential of lycopene, β-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free Radical Biological and Medicine. (2002) 32: 1293-1303.
11. Huang MT, Ho CT, Wang ZY, Ferraro T, Lou YR, Stauber K, Ma W, Georgiadis C, Laskin JD and Conney AH, Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Research. (1994) 54: 701-708.
12. Del Bano MJ, Castillo J, Benavente-Garcia O, Lorente J, Martin-Gil R, Acevedo C and Alcaraz M Radioprotectiveantimutagenic effects of rosemary phenolics against chromosomal damage induced in human lymphocytes by gamma-rays. J. Agricultural and Food Chemistry. (2006) 54: 2064-2068. Hardy MP, Kirby JD, Hess RA and Cooke PS. Leydig
13. Cells increase their numbers but decline in steroidogenic function in the adult rat after neonatal hypothyroidism. Endocrinology. (1993) 132: 2417-20.
14. McLachlan RI, Wreford NG, ÔDonnell L, de Kretser DM and Robertson DM, The endocrine regulation of spermatogenesis: independent roles for testosterone and FSH. J. Endocrinol. (1996) 148: 1-9.
15. Nuiser MK, Bataineh HN and Daradkah HM, Adverse effect of rosemary (Rosmarinus officinalis L.) on reproductive function in adult male rats. Exp. Biol. Med. (2007) 232: 809-13.
16. Aruoma OI, Halliwell B, Aeschbach R and Loligers J, Antioxidant and pro-oxidant properties of active Rosmarinus officinalis constituents: carnosol and carnosic acid. Xenobiotica. (1992) 22: 257-268.
17. Cuvelier ME, Bondety V and Berset C, Behaviour of phenolic antioxidants in a partioned medium: structure-activity relationship. Journal of American Oil Chemistry Society. (2000) 77: 819-823.
18. Pathak V, Shirota O, Sekita S, Hirayama Y, Hakamata Y, Hayashi T, Yanagawa T and Satake M, Antiandrogenic phenolic constituents from Dalbergia cochinchinensis. Phytochemistry. (1997) 46: 1219-23.
19. Gumbinger HG, Winterhoff H, Sourgens H, Kemper FH and Wylde R, Formation of compounds with antigonadotropic activity from inactive phenolic precursors. Contraception. (1981) 23: 661-6.
20. Nahrstedt A, Albrecht M, Wray V, Gumbinger HG, John M, Winterhoff H and Kemper FH, Structures of compounds with antigonadotropic activity obtained by in-vitro oxidation of caffeic acid. Planta Med. (1990) 56: 395-8.
21. Sohrabi D, Alipour M and Awsat Mellati A, Effect of Metronidazole on Spermatogenesis, Plasma Gonadotrophins and Testosterone in Male Rats. Iranian J. Pharm. Res. (2007) 4: 279-83.