Drug Resistance in Natural Isolates of Leishmania donovani s.l. Promastigotes Is Dependent of Pgp170 Expression

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Messaritakis, Ippokratis ^a   Christodoulou, Vasiliki ^a,b   Mazeris, Apostolos ^b   Koutala, Eleni ^a   Vlahou, Antonia ^c   Papadogiorgaki, Sevasti ^a   Antoniou, Maria ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b Veterinary Services of Cyprus   (Cyprus)

^c BIOMEDICAL RESEARCH FOUNDATION   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; GLYCOPROTEIN P 170; MEGLUMINE ANTIMONATE; MILTEFOSINE; MULTIDRUG RESISTANCE PROTEIN; RHODAMINE 123; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; GENE; IN VITRO STUDY; LEISHMANIA DONOVANI; MDR GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMASTIGOTE; PROTEIN EXPRESSION; PROTEOMICS; SURVIVAL RATE; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

AMPHOTERICIN B; ANTIPROTOZOAL AGENTS; DRUG RESISTANCE; LEISHMANIA DONOVANI; MEGLUMINE; MEMBRANE PROTEINS; ORGANOMETALLIC COMPOUNDS; PHOSPHORYLCHOLINE; PROTOZOAN PROTEINS; RHODAMINE 123;

ENTAMOEBA HISTOLYTICA; LEISHMANIA DONOVANI;

EID: 84878909214     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065467     Document Type: Article

References (55)

1. Schonian G, Mauricio I, Gramiccia M, Canavate C, Boelaert M, et al. (2008) Leishmaniases in the Mediterranean in the era of molecular epidemiology. Trends Parasitol 24: 135-142 doi: 110.1016/j.pt.2007.1012.1006.
2. Antoniou M, Haralambous C, Mazeris A, Pratlong F, Dedet JP, et al. (2008) Leishmania donovani leishmaniasis in Cyprus. Lancet Infect Dis 8: 6-7.
3. Ravel C, Cortes S, Pratlong F, Morio F, Dedet JP, et al. (2006) First report of genetic hybrids between two very divergent Leishmania species: Leishmania infantum and Leishmania major. Int J Parasitol 36: 1383-1388.
4. Haralambous C, Antoniou M, Pratlong F, Dedet JP, Soteriadou K, (2008) Development of a molecular assay specific for the Leishmania donovani complex that discriminates L. donovani/Leishmania infantum zymodemes: a useful tool for typing MON-1. Diagn Microbiol Infect Dis 60: 33-42.
5. Mazeris A, Soteriadou K, Dedet JP, Haralambous C, Tsatsaris A, et al. (2010) Leishmaniases and the Cyprus paradox. Am J Trop Med Hyg 82: 441-448.
6. Croft SL, Sundar S, Fairlamb AH, (2006) Drug resistance in leishmaniasis. Clin Microbiol Rev 19: 111-126.
7. Thakur CP, Kumar M, Pandey AK, (1991) Comparison of regimes of treatment of antimony-resistant kala-azar patients: a randomized study. Am J Trop Med Hyg 45: 435-441.
8. Jha TK, Olliaro P, Thakur CP, Kanyok TP, Singhania BL, et al. (1998) Randomised controlled trial of aminosidine (paromomycin) v sodium stibogluconate for treating visceral leishmaniasis in North Bihar, India. Bmj 316: 1200-1205.
9. Sundar S, (2001) Drug resistance in Indian visceral leishmaniasis. Trop Med Int Health 6: 849-854.
10. Mookerjee Basu J, Mookerjee A, Banerjee R, Saha M, Singh S, et al. (2008) Inhibition of ABC transporters abolishes antimony resistance in Leishmania Infection. Antimicrob Agents Chemother 52: 1080-1093.
11. Coelho AC, Messier N, Ouellette M, Cotrim PC, (2007) Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes. Antimicrob Agents Chemother 51: 3030-3032.
12. Riordan JR, Deuchars K, Kartner N, Alon N, Trent J, et al. (1985) Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 316: 817-819.
13. Higgins CF, (1992) ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8: 67-113.
14. Hughes AL, (1994) Evolution of the ATP-binding-cassette transmembrane transporters of vertebrates. Mol Biol Evol 11: 899-910.
15. Ling V, (1997) Multidrug resistance: molecular mechanisms and clinical relevance. Cancer Chemother Pharmacol 40: S3-8.
16. Lee GY, Croop JM, Anderson E, (1998) Multidrug resistance gene expression correlates with progesterone production in dehydroepiandrosterone-induced polycystic and equine chorionic gonadotropin-stimulated ovaries of prepubertal rats. Biol Reprod 58: 330-337.
17. Kamau S, Hurtado M, Muller-Doblies UU, Grimm F, Nunez R, (2000) Flow cytometric assessment of allopurinol susceptibility in Leishmania infantum promastigote. Cytometry 40: 353-360.
18. Lemesre JL, Darcy F, Kweider M, Capron A, Santoro F, (1988) Requirements of defined cultivation conditions for standard growth of Leishmania promastigotes in vitro. Acta Trop 45: 99-108.
19. Lightner LK, Chulay JD, Bryceson AD, (1983) Comparison of microscopy and culture in the detection of Leishmania donovani from splenic aspirates. Am J Trop Med Hyg 32: 296-299.
20. Roubelakis MG, Pappa KI, Bitsika V, Zagoura D, Vlahou A, et al. (2007) Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells. Stem Cells Dev 16: 931-952.
21. GeneDB website. Available: http://www.genedb.org. Accessed 2013 Apr 10.
22. Koliou MG, Soteriades ES, Ephros M, Mazeris A, Antoniou M, et al. (2008) Hemophagocytic lymphohistiocytosis associated with Epstein Barr virus and Leishmania donovani coinfection in a child from Cyprus. J Pediatr Hematol Oncol 30: 704-707 doi: 710.1097/MPH.1090b1013e31816916f31816916.
23. Ouellette M, Ward S (2002) Drug resistance in parasites. In Marr J, Nielsen T, Komuniecki R, editors. Molecular medical Parasitology. New York: Academic Press. 395-430.
24. Yah CS, Fatumo S, (2010) In-silico studies of multi drug resistance (MDR) genetic markers of Plasmodium species. J Comput Biol Bioinform Res 2: 005-009.
25. Delgadillo DM, Perez DG, Gomez C, Ponce A, Paz F, et al. (2002) The Entamoeba histolytica EhPgp5 (MDR-like) protein induces swelling of the trophozoites and alters chloride-dependent currents in Xenopus laevis oocytes. Microb Drug Resist 8: 15-26.
26. Callahan HL, Beverley SM, (1991) Heavy metal resistance: a new role for P-glycoproteins in Leishmania. J Biol Chem 266: 18427-18430.
27. Katakura K, Chang KP, (1989) H DNA amplification in Leishmania resistant to both arsenite and methotrexate. Mol Biochem Parasitol 34: 189-191.
28. Ouellette M, Fase-Fowler F, Borst P, (1990) The amplified H circle of methotrexate-resistant leishmania tarentolae contains a novel P-glycoprotein gene. Embo J 9: 1027-1033.
29. Ouellette M, Hettema E, Wust D, Fase-Fowler F, Borst P, (1991) Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania. Embo J 10: 1009-1016.
30. Henderson DM, Sifri CD, Rodgers M, Wirth DF, Hendrickson N, et al. (1992) Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene. Mol Cell Biol 12: 2855-2865.
31. Hendrickson N, Sifri CD, Henderson DM, Allen T, Wirth DF, et al. (1993) Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani. Mol Biochem Parasitol 60: 53-64.
32. Blast website. Available: http://blast.ncbi.nlm.nih.gov/Blast.cgi. Accessed 2013 Apr 15.
33. Twentyman PR, Rhodes T, Rayner S, (1994) A comparison of rhodamine 123 accumulation and efflux in cells with P-glycoprotein-mediated and MRP-associated multidrug resistance phenotypes. Eur J Cancer 30A: 1360-1369.
34. Mandal G, Sarkar A, Saha P, Singh N, Sundar S, et al. (2009) Functionality of drug efflux pumps in antimonial resistant Leishmania donovani field isolates. Indian J Biochem Biophys 46: 86-92.
35. Rioux JA, Lanotte G, Serres E, Pratlong F, Bastien P, et al. (1990) Taxonomy of Leishmania. Use of isoenzymes. Suggestions for a new classification. Ann Parasitol Hum Comp 65: 111-125.
36. Gouzelou E, Haralambous C, Amro A, Mentis A, Pratlong F, et al. (2012) Multilocus microsatellite typing (MLMT) of strains from Turkey and Cyprus reveals a novel monophyletic L. donovani sensu lato group. PLoS Negl Trop Dis 6: e1507 doi: 1510.1371/journal.pntd.0001507.
37. Mary C, Faraut F, Deniau M, Dereure J, Aoun K, et al. (2010) Frequency of drug resistance gene amplification in clinical leishmania strains. Int J Microbiol 2010: 819060 doi: 819010.811155/812010/819060.
38. Chow LM, Wong AK, Ullman B, Wirth DF, (1993) Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii. Mol Biochem Parasitol 60: 195-208.
39. Gramiccia M, Gradoni L, Orsini S, (1992) Decreased sensitivity to meglumine antimoniate (Glucantime) of Leishmania infantum isolated from dogs after several courses of drug treatment. Ann Trop Med Parasitol 86: 613-620.
40. Dey S, Ouellette M, Lightbody J, Papadopoulou B, Rosen BP, (1996) An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae. Proc Natl Acad Sci U S A 93: 2192-2197.
41. Dey S, Papadopoulou B, Haimeur A, Roy G, Grondin K, et al. (1994) High level arsenite resistance in Leishmania tarentolae is mediated by an active extrusion system. Mol Biochem Parasitol 67: 49-57.
42. Singh AK, Liu HY, Lee ST, (1994) Atomic absorption spectrophotometric measurement of intracellular arsenite in arsenite-resistant Leishmania. Mol Biochem Parasitol 66: 161-164.
43. Messaritakis I, Mazeris A, Koutala E, Antoniou M, (2010) Leishmania donovani s.l.: evaluation of the proliferation potential of promastigotes using CFSE staining and flow cytometry. Exp Parasitol 125: 384-388 doi: 310.1016/j.exppara.2010.1003.1006.
44. Antoniou M, Doulgerakis C, Pratlong F, Dedet JP, Tselentis Y, (2004) Short report: Treatment failure due to mixed infection by different strains of the parasite Leishmania infantum. Am J Trop Med Hyg 71: 71-72.
45. Cuervo P, de Jesus JB, Junqueira M, Mendonca-Lima L, Gonzalez LJ, et al. (2007) Proteome analysis of Leishmania (Viannia) braziliensis by two-dimensional gel electrophoresis and mass spectrometry. Mol Biochem Parasitol 154: 6-21.
46. Assimon VA, Gillies AT, Rauch JN, Gestwicki JE, (2013) Hsp70 protein complexes as drug targets. Curr Pharm Des 19: 404-417.
47. Da Silva EC, Rayol CD, Moura PMMF, Andrade PP (2008) Partial purification, immunogenicity and putative new localization of a native Leishmania heat shock protein 70. Parasitol Latinoam: 4-11.
48. Vega VL, Rodriguez-Silva M, Frey T, Gehrmann M, Diaz JC, et al. (2008) Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. J Immunol 180: 4299-4307.
49. Vergnes B, Gourbal B, Girard I, Sundar S, Drummelsmith J, et al. (2007) A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death. Mol Cell Proteomics 6: 88-101.
50. Kumar A, Sisodia B, Misra P, Sundar S, Shasany AK, et al. (2010) Proteome mapping of overexpressed membrane-enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania donovani. Br J Clin Pharmacol 70: 609-617 doi: 610.1111/j.1365-2125.2010.03716.x.
51. Singh R, Kumar D, Duncan RC, Nakhasi HL, Salotra P, (2010) Overexpression of histone H2A modulates drug susceptibility in Leishmania parasites. Int J Antimicrob Agents 36: 50-57.
52. Leu JI, Pimkina J, Frank A, Murphy ME, George DL, (2009) A small molecule inhibitor of inducible heat shock protein 70. Mol Cell 36: 15-27 doi: 10.1016/j.molcel.2009.1009.1023.
53. Leu JI, Pimkina J, Pandey P, Murphy ME, George DL, (2011) HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Mol Cancer Res 9: 936-947 doi: 910.1158/1541-7786.MCR-1111-0019.
54. Purkait B, Kumar A, Nandi N, Sardar AH, Das S, et al. (2012) Mechanism of amphotericin B resistance in clinical isolates of Leishmania donovani. Antimicrob Agents Chemother 56: 1031-1041 doi: 1010.1128/AAC.00030-00011.
55. Alvar J, Velez ID, Bern C, Herrero M, Desjeux P, et al. (2012) Leishmaniasis worldwide and global estimates of its incidence. PLoS One 7: e35671 doi: 35610.31371/journal.pone.0035671.