Calcium lignosulphonate: Re-evaluation of relevant endpoints to re-confirm validity and NOAEL of a 90-day feeding study in rats

Regulatory Toxicology and Pharmacology

Volumn 66, Issue 3, 2013, Pages 286-299

  Thiel, Anette ^a   Braun, William ^b   Cary, Maurice G ^c   Engelhardt, Jeffery A ^d   Goodman, Dawn G ^e   Hall, William C ^f   Romeike, Annette ^g   Ward, Jerrold M ^h  

^a DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

^b Harlan   (Switzerland)

^c Pathology Experts GmbH   (Switzerland)

^d EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

^e Consultant in Toxicologic Pathology ^*  (United States)

^f Hall Consulting Inc ^*  (United States)

^g IPSAR Consulting   (France)

^h Global VetPathology   (United States)

Author keywords

Histiocytosis; Ligninsulphonate; Lignosulphonate; PWG

Indexed keywords

CALCIUM LIGNOSULPHONATE; POLYMER; UNCLASSIFIED DRUG;

ACCLIMATIZATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BODY WEIGHT; CELL PROLIFERATION; CONTROLLED STUDY; EPIDIDYMIS; ESTRUS CYCLE; FEEDING BEHAVIOR; FEMALE; GRIP STRENGTH; HEALTH STATUS; HISTIOCYTOSIS; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOGENICITY; LYMPH NODE; LYMPHOID CELL; MALE; MESENTERY LYMPH NODE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; RAT; SEMEN ANALYSIS; SEX DIFFERENCE; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SUBCUTANEOUS NODULE; VALIDITY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDPOINT DETERMINATION; FEMALE; GUIDELINES AS TOPIC; HISTIOCYTOSIS; LIGNIN; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PRODUCT SURVEILLANCE, POSTMARKETING; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; TOXICITY TESTS, SUBCHRONIC;

ANIMALIA; RATTUS;

EID: 84878899586     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2013.04.007     Document Type: Article

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