Compression and compaction properties of plasticised high molecular weight hydroxypropylmethylcellulose (HPMC) as a hydrophilic matrix carrier

International Journal of Pharmaceutics

Volumn 311, Issue 1-2, 2006, Pages 26-32

  Hardy, I J ^a   Cook, W G ^b   Melia, C D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Compaction; HPMC; Hydroxypropylmethylcellulose; Matrix; Mechanical properties; Plasticiser

Indexed keywords

GLYCEROL; HYDROXYPROPYLMETHYLCELLULOSE; PLASTICIZER; PROPYLENE GLYCOL; SEBACIC ACID DIBUTYL ESTER; TRIACETIN;

ARTICLE; HYDROPHILICITY; MOLECULAR WEIGHT; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET FORMULATION; TENSILE STRENGTH; THERMAL ANALYSIS;

CHEMISTRY, PHARMACEUTICAL; DICARBOXYLIC ACIDS; DRUG CARRIERS; ELASTICITY; METHYLCELLULOSE; MODELS, CHEMICAL; MOLECULAR WEIGHT; PLASTICIZERS; POLYMERS; PRESSURE; PROPYLENE GLYCOLS; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TENSILE STRENGTH; TRIACETIN;

EID: 33644635060     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.12.025     Document Type: Article

References (31)

1. M. Celik, and K. Marshall Use of a compaction simulator system in tableting research Drug Dev. Ind. Pharm. 15 1989 759 800
2. E. Doelker Cellulose derivatives Adv. Polym. Sci 1097 1993 199 265
3. C. Entwistle, and R. Rowe Plasticisation of cellulose ethers used in the film coating of tablets J. Pharm. Pharmacol. 31 1979 269 272
4. M. Eriksson, and G. Alderborn The effect of particle fragmentation and deformation on the interparticulate bond formation process during powder compaction Pharm. Res. 12 1995 1031 1039
5. J.T. Fell, and J.M. Newton Determination of tablet strength by diameteral-compression test J. Pharm. Sci. 59 1970 688 691
6. R. Heckel Density pressure relationships in powder compaction Trans. Metal. Soc. 221 1961 671 675
7. R. Heckel An analysis of powder compaction phenomena Trans. Metal. Soc. 221 1961 1001 1008
8. J. Ilkka, and P. Paronen Prediction of the compression behaviour of powder mixtures by the Heckel equation Int. J. Pharm. 94 1993 181 187
9. S. Malamataris, and T. Karidas Effect of particle size and sorbed moisture on the tensile strength of some tabletted hydroxypropyl methyl cellulose (HPMC) polymers Int. J. Pharm. 104 1994 115 123
10. S. Malamataris, T. Karidas, and P. Goidas Effect of particle size and sorbed moisture on the compression behaviour of some hydroxypropyl methyl cellulose (HPMC) polymers Int. J. Pharm. 103 1994 205 215
11. C.D. Melia Hydrophilic matrix sustained release systems based on polysaccharide carriers Crit. Rev. Ther. Drug Carrier Syst. 8 1991 395 421
12. A. Nokhodchi, J. Ford, P. Rowe, and M. Rubinstein The effect of moisture on the Heckel and energy analysis of Hydroxypropyl methyl cellulose 2208 (HPMC K4M) J. Pharm. Pharmacol. 48 1996 1122 1127
13. A. Nokhodchi, J. Ford, P. Rowe, and M. Rubinstein The influence of moisture content on the consolidation properties of Hydroxypropyl methyl cellulose K4M (HPMC 2208) J. Pharm. Pharmacol. 48 1996 1116 1121
14. A. Nokhodchi, and M. Rubinstein The effect of moisture content on the compaction properties of the binary mixture of hydroxypropylmethyl cellulose K4M/ibuprofen STP Pharm. Sci. 8 1998 349 356
15. A. Nokhodchi, and M.H. Rubenstein An overview of the effects of material and process variables on the compaction and compression properties of hydroxypropylmethyl cellulose and ethyl cellulose STP Pharm. Sci. 11 2001 195 202
16. C. Nystrom, G. Alderborn, M. Duberg, and P. Karehill Bonding surface area and bonding mechanism Two important factors for understanding powder compactability Drug Dev. Ind. Pharm. 19 1993 2143 2196
17. C. Nystrom, and P. Karehill The importance of intermolecular bonding forces and the concept of bonding surface area G. Alderborn C. Nystrom Pharmaceutical Powder Compaction Technology 1996 Marcel Dekker Inc. New York 17 53
18. K.M. Picker The 3D model: explaining densification and deformation mechanisms by using 3D parameter plots Drug Dev. Ind. Pharm. 30 2004 413 425
19. K.M. Picker The relevance of glass transition temperature for the process of tablet formation J. Therm. Anal. Calorimetry 73 2003 597 605
20. A.R. Rajabi-Siahboomi, R.W. Bowtell, P. Mansfield, A. Henderson, M.C. Davies, and C.D. Melia Structure and behaviour in hydrophilic matrix sustained release dosage forms: 2 NMR-imaging studies of the dimensional changes in the gel layer and core of HPMC matrices undergoing hydration J. Control. Rel. 31 1994 121 128
21. G. Ragnarsson, and J. Sjogren Work of friction and network during compaction J. Pharm. Pharmacol. 35 1983 201 204
22. R. Roberts, and R. Rowe The effect of punch velocity on the compaction of a variety of materials J. Pharm. Pharmacol. 37 1985 377 384
23. R. Roberts, and R. Rowe Brittle/ductile behaviour in pharmaceutical materials used in tabletting Int. J. Pharm. 36 1987 205 209
24. R. Rowe, and S. Forse The effect of plasticiser type and concentration on the incidence of bridging of intagliations on film-coated tablets J. Pharm. Pharmacol. 33 1981 174 175
25. R. Rowe Some fundamental properties of polymeric materials and their application in film coating formulations - a review Int. J. Pharm. Tech. Prod. Manuf. 3 1982 3 8
26. R. Rowe, A. Kotaras, and E. White An evaluation of the plasticising efficiency of the dialkyl phthalates in ethyl cellulose films using the torsional braid pendulum Int. J. Pharm. 22 1984 57 62
27. P. Sakellariou, R. Rowe, and E. White An evaluation of the interaction and plasticising efficiency of the polyethylene glycols in ethyl cellulose and hydroxypropyl methyl cellulose films using the torsional braid pendulum Int. J. Pharm. 31 1986 55 64
28. P. Sakellariou, and R. Rowe Interactions in cellulose derivative films for oral drug delivery Progr. Polym. Sci. 20 1995 889 942
29. J. Sonnergaard A critical evaluation of the Heckel equation Int. J. Pharm. 193 1999 63 71
30. K. Van-der-Voort-Maarschalk, K. Zuurman, H. Vromans, G. Bolhuis, and C. Lerk Stress relaxation of compacts produced from viscoelastic materials Int. J. Pharm. 151 1997 27 34
31. K. Van-der-Voort-Maarschalk, H. Vromans, G. Bolhuis, and C. Lerk Influence of plasticisers on tabletting properties of polymers Drug Dev. Ind. Pharm. 24 1998 261 268