Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model

Journal of Urology

Volumn 190, Issue 1, 2013, Pages 350-356

  Fan, Min ^a   Xu, Xianlin ^a   He, Xiaozhou ^a   Chen, Lujun ^a   Qian, Liren ^b   Liu, Jipu ^a   Qing, Jiandi ^a   Chao, Zhifu ^a   Sun, Xuejun ^c  

^a THE THIRD AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b NAVY GENERAL HOSPITAL   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; diabetes mellitus; erectile dysfunction; hydrogen; penis

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; HYDROGEN; MALONALDEHYDE; NITRATE; NITRIC OXIDE SYNTHASE; NITRITE; PROTEIN BAX; PROTEIN BCL 2; SODIUM CHLORIDE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CAVERNOUS NERVE ELECTROSTIMULATION; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; ENZYME ACTIVITY; ERECTILE DYSFUNCTION; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; INTRACAVERNOUS PRESSURE; MALE; NERVE STIMULATION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PENIS ERECTION; PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; ERECTILE DYSFUNCTION; HYDROGEN; IMMUNOHISTOCHEMISTRY; MALE; MALONDIALDEHYDE; NITRIC OXIDE SYNTHASE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; REFERENCE VALUES; SODIUM CHLORIDE; STREPTOZOCIN; TREATMENT OUTCOME;

EID: 84878876896     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2012.12.001     Document Type: Article

References (22)

1. S. Papaharitou, L. Athanasiadis, E. Nakopoulou Erectile dysfunction and premature ejaculation are the most frequently self-reported sexual concerns: profiles of 9,536 men calling a helpline Eur Urol 49 2006 557
2. C.G. Bacon, F.B. Hu, E. Giovannucci Association of type and duration of diabetes with erectile dysfunction in a large cohort of men Diabetes Care 25 2002 1458
3. I. Goldstein, J.M. Young, J. Fischer Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study Diabetes Care 26 2003 777
4. A. Ceriello The possible role of postprandial hyperglycaemia in the pathogenesis of diabetic complications Diabetologia 46 suppl. 2003 M9
5. A. Agarwal, K.C. Nandipati, R.K. Sharma Role of oxidative stress in the pathophysiological mechanism of erectile dysfunction J Androl 27 2006 335
6. E.G. Valente, D. Vernet, M.G. Ferrini L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures Nitric Oxide 9 2003 229
7. S. Kajiyama, G. Hasegawa, M. Asano Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance Nutr Res 28 2008 137
8. R. Jiang, J.H. Chen, J. Jin Ultrastructural comparison of penile cavernous tissue between hypertensive and normotensive rats Int J Impot Res 17 2005 417
9. M. Yamanaka, M. Shirai, H. Shiina Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats J Urol 170 2003 291
10. M. Shirai, M. Yamanaka, H. Shiina Vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat Biochem Biophys Res Commun 341 2006 755
11. S. Cuzzocrea, R.J. Reiter Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury Eur J Pharmacol 426 2001 1
12. H. Kasai, P.F. Crain, Y. Kuchino Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair Carcinogenesis 7 1986 1849
13. J.K. Ryu, T. Lee, D.J. Kim Free radical-scavenging activity of Korean red ginseng for erectile dysfunction in non-insulin-dependent diabetes mellitus rats Urology 65 2005 611
14. A. Keegan, M.A. Cotter, N.E. Cameron Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats Diabetologia 42 1999 343
15. M. Ushiyama, T. Kuramochi, S. Yagi Antioxidant treatment with alpha-tocopherol improves erectile function in hypertensive rats Hypertens Res 31 2008 1007
16. T.D. Strong, M.A. Gebska, A.L. Burnett Endothelium-specific gene and stem cell-based therapy for erectile dysfunction Asian J Androl 10 2008 14
17. T.J. Bivalacqua, M.F. Usta, H.C. Champion Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats J Urol 169 2003 1911
18. M. Hugyecz, E. Mracsko, P. Hertelendy Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus Brain Res 1404 2011 31
19. I. Ohsawa, M. Ishikawa, K. Takahashi Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals Nat Med 13 2007 688
20. A. Nakao, Y. Toyoda, P. Sharma Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome - an open label pilot study J Clin Biochem Nutr 46 2010 140
21. M. Ito, T. Ibi, K. Sahashi Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies Med Gas Res 1 2011 24
22. H. Ono, Y. Nishijima, N. Adachi Hydrogen(H2) treatment for acute erythematous skin diseases A report of 4 patients with safety data and a noncontrolled feasibility study with H2 concentration measurement on two volunteers. Med Gas Res 2 2012 14