Insulin resistance and hypothyroidism: A complex relationship in non-alcoholic fatty liver disease

Journal of the Indian Medical Association

Volumn 111, Issue 5, 2013, Pages

  Misra, Sanjukta ^a   Singh, Bratati ^a  

^a SIKSHA O ANUSANDHAN DEEMED TO BE UNIVERSITY   (India)

Author keywords

HOMA IR; Insulin resistance; Metabolic syndrome; Non alcoholic fatty liver disease

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THYROTROPIN;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; HUMAN; HYPOTHYROIDISM; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; PREVALENCE;

EID: 84878872844     PISSN: 00195847     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Grundy S, Brewer B, Cleeman J, Smith S, Lenfant C. Definition of metabolic syndrome. Report of the National Heart, Lung and Blood Institute/ American Heart Association conference on scientific issue related to definition. Circulation 2004; 109: 433-8.
2. Angulo P. Non alcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-31.
3. Rector RS, Thyfault JP, Wei Y, Ibdah JA. Nonalcoholic fattyliver disease and the metabolic syndrome: an update. World J Gastroenterol 2008; 14: 185-92.
4. Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Marini R, et al. Non alcoholic fatty liver steatohepatitis and the metabolic syndrome. Hepatology 2003; 37: 917-23.
5. Expert panel of detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Executive summary of third report of the National Cholesterol Education Programme (NCEP). JAMA 2001; 285: 2486-97.
6. Marchesini G, Brizi M, Morselli-Labate AM, Bianchi G, Bugianesi E, McCullough AJ, et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999; 107: 450-5.
7. Ruderman N, Cacicedo J, Itania S, Yagihashi N, Saha A, Ye J, et al. Malonyl CoA and AMP activated protein kinase (AMPK): possible link between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem SocTrans 2003; 31: 202-6.
8. Liangpunsakul S, Chalasani N. Is hypothyroidism a risk factor for non alcoholic steatohepatitis. J Clin Gastroenterol 2003; 37: 340-3.
9. Pagadala M, editor. Assessment of the prevalence of hypothyroidism in nonalcoholic fatty liver disease. [Abstr P]. San Diego: American College of Gastro-enterology, 2009: 177.
10. Duntas LH. Thyroid disease and lipids. Thyroid 2002; 12: 287-93.
11. Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005; 42: 987-1000.
12. Alberti KG, Zimme P, Shaw J. The metabolic syndrome: a new worldwide definition. Lancet 2005; 366: 1059-62.
13. Maratou E, Hadjidakis DJ, Kollias A, Tsegka K, Peppa M, Alevizaki M, et al. Studies of insulin resistance in patientswith clinical and subclinical hypothyroidism. Eur J Endocrinol 2009; 160: 785-90.
14. Bakker SJ, ter Maaten JC, Popp-Snijders C, Slaets JP, Heine RJ, Gans RO. The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects. J Clin Endocrinol Metab 2001; 86: 1206-11.
15. Saverymuttu SH, Joseph AEA, Maxwell JD. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Br Med J 1986; 292:13-5.
16. Mathews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and b cell function from plasma fasting glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-9.
17. Marwaha R, Chopra S, Gopalkrishnan S, Sharma B, Kanwar R, Sastry A, et al. Establishment of reference range for thyroid hormones in normal pregnant Indian women. Br J Obstet Gynaecol 2008; 115: 602-6.
18. Mc Grath MF, Bogosian G, Fabellar AC, Staub RL, Vicini JL, Widger LA. Measurement of bovine somatotropin (bST) and insulin-like growth factor-1(IGF-1) in bovine milk using electrochemiluminescent assay. J Agr Food Chem 2008; 56: 7044-8.
19. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein in plasma without the use of preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
20. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005; 365: 1415-28.
21. Angelico F, Ben MD, Conti R, Francioso S, Feole K, Fiorello S, et al. Insulin resistance, the metabolic syndrome, and nonalcoholic fatty liver disease. J Clin Endocrinol Metab 2005; 90: 1578-82.
22. Hui JM, Hodge A, Farrell GC, Kench JG, Kriketos A, George J, et al. Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology 2004; 40: 46-54.
23. Annemieke R, Stephan JL, Thera PL, Rijk OBG, Bruce HRB. Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects. J Clin Endocrinol Metab 2007; 92: 491-6.
24. Tayal D, Goswami B, Gupta VK, Mallika V. Evaluation of lipid profile in hypothyroid patients: our experience. Thyroid Res Pract 2008; 5: 43-7.
25. Tuzcu A, Bahceci M, Gokalp D, Tuzun Y, Gunes K. Subclinical hypothyroidism may be associated with elevated high Creactive protein (low grade inflammation) and fasting hyperinsulinemia. Endocr J 2005; 52: 89-94.
26. Iqbal A, Jorde R, Figenschau Y. Serum lipid levels In relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromsø Study. J Intern Med 2006; 260: 53-61.