Rapid insight into heating-induced phase transformations in the solid state of the calcium salt of atorvastatin using multivariate data analysis

Pharmaceutical Research

Volumn 30, Issue 3, 2013, Pages 826-835

  Christensen, Niels Peter Aae ^a   Van Eerdenbrugh, Bernard ^b,d   Kwok, Kaho ^b   Taylor, Lynne S ^b   Bond, Andrew D ^c   Rades, Thomas ^a   Rantanen, Jukka ^a   Cornett, Claus ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

Author keywords

calcium atorvastatin; multivariate data analysis; phase transformation; Raman spectroscopy; synchrotron XRPD

Indexed keywords

ATORVASTATIN; CALCIUM SALT;

ANALYTIC METHOD; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; HEATING; HYDRATION; LIQUID CRYSTAL; MELTING POINT; MULTIVARIATE CURVE RESOLUTION; PHASE TRANSITION; POLARIZATION MICROSCOPY; PRIORITY JOURNAL; RAMAN SPECTROMETRY; STRUCTURE ANALYSIS; TEMPERATURE MEASUREMENT; THERMOGRAVIMETRY; X RAY POWDER DIFFRACTION;

ANTICHOLESTEREMIC AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; FREEZING; HEATING; HEPTANOIC ACIDS; MULTIVARIATE ANALYSIS; PHASE TRANSITION; POWDER DIFFRACTION; PYRROLES; SPECTRUM ANALYSIS, RAMAN; THERMOGRAVIMETRY; WATER; X-RAY DIFFRACTION;

EID: 84878872158     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0923-1     Document Type: Article

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