Physical stability and solubility of the thermotropic mesophase of fenoprofen calcium as pure drug and in a tablet formulation

International Journal of Pharmaceutics

Volumn 247, Issue 1-2, 2002, Pages 147-157

  Patterson, James ^a   Bary, Andrew ^a   Rades, Thomas ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Fenoprofen calcium; Fenoprofen calcium tablets; Mesophase; Physical stability; Solubility; Thermotropic liquid crystals

Indexed keywords

FENOPROFEN CALCIUM; PRODRUG;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; HEAT TREATMENT; INFRARED SPECTROSCOPY; LIQUID CRYSTAL; PRIORITY JOURNAL; REFLECTOMETRY; SCANNING ELECTRON MICROSCOPY; TABLET; TEMPERATURE; WATER LOSS; X RAY POWDER DIFFRACTION;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG STABILITY; FENOPROFEN; SOLUBILITY; TABLETS;

EID: 0037168221     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00402-7     Document Type: Article

References (18)

1. Brittain H.G. Physical Characterisation of Pharmaceutical Solids. 1995;Marcel Dekker, New York.
2. Demus D., Richter L. Textures of Liquid Crystals. 1978;Verlag-Chemie, Weinheim, New York.
3. Demus D., Zaschke H. Flüssige Kristalle in Tabellen II. 1984;Verlag für Grundstoffindustrie, Leipzig.
4. Forster A., Hempenstall J., Rades T. Characterisation of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers. J. Pharm. Pharmacol. 53:2001;303-315.
5. Gray G.W., Goodby J.W.G. Smectic Liquid Crystals - Textures and Structure. 1972;Leonard Hill, Glasgow.
6. Hamann H.J., Müller-Goymann C.C. Lyotroper Mesoprophismus von Arzneistoffen unter besonderer Berücksichtigung der Profene. Acta Pharm. Technol. 33:1987;67-73.
7. Kriwet K., Müller-Goymann C.C. Mutual interactions between diclofenac diethylamine and phospholipids-investigation on the microstructure of the arisen systems. Pharmazie. 49:1994;187-191.
8. Luzzati P.V., Mustacchi H., Skoulios A., Husson F. La structure des colloides d'association. I. Les phases liquide-cristallines des systemes amphiphile-eau. Acta Cryst. 13:1960;660-667.
9. Mlodozeniec A.R. Thermodynamics and physical properties of a lyotropic mesophase (liquid crystal) and micellar solution of an ionic amphiphile. J. Soc. Cosmet. Chem. 29:1978;659-683.
10. Physicians Desk Reference, 1998. Media Economics Company, Montvale, NJ, pp. 85 7-859.
11. Rades T., Müller-Goymann C.C. Structural investigations on the liquid crystalline phases of fenoprofen. Pharm. Pharmacol. Lett. 2:1992;131-134.
12. Rades T., Müller-Goymann C.C. Melting behaviour and thermotropic mesomorphism of fenoprofen salts. Eur. J. Pharm. Biopharm. 40:1994;277-282.
13. Rades T., Padmadisastra Y., Müller-Goymann C.C. Thermal behaviour and solubility of fenoprofen calcium. Pharmazie. 51:1996;846-851.
14. Spegt P., Skoulios A. Structure des phases mésomorphique du stéarate de calcium anhydre. CR Acad. Sci. 251:1960;2199.
15. Schülke U., 1987. Synthese und Untersuchung von Flüssigkristallinen, Semiflexiblen Hauptkettenpolymeren, Thesis, Technical University of Darmstadt, Germany.
16. Usselmann B., 1987. Beitrag zur Strukturaufklärung Topischer Zubereitungen mit Fettalkoholpolyethylenglycolethern und Cholesterol als Tensiden. Ph.D. Thesis, Technical University of Braunschweig, Germany.
17. Vadas E.B., Toma P., Zografi G. Solid state transitions initiated by water vapor sorption of crystalline L-660,711, a leukotriene D4 receptor agonist. Pharm. Res. 8:1991;148-155.
18. Ward C.K., Schirmer R.E. Fenoprofen Calcium. Flory K., Analytical Profiles of Drug Substances. 6:1977;161-182 Academic Press, New York.