Molecular profiling diagnosis in unknown primary cancer: Accuracy and ability to complement standard pathology

Journal of the National Cancer Institute

Volumn 105, Issue 11, 2013, Pages 782-790

  Greco, F Anthony ^a   Lennington, Wayne J ^b   Spigel, David R ^a   Hainsworth, John D ^a  

^a SARAH CANNON RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOCARCINOMA; ADULT; AGED; ARTICLE; BLADDER CANCER; BRAIN CANCER; BREAST CANCER; CANCER DIAGNOSIS; CANCER LOCALIZATION; CANCER OF UNKNOWN PRIMARY SITE; CANCER PATIENT; CARCINOMA; COLORECTAL CANCER; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC EQUIPMENT; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST ACCURACY STUDY; ENDOMETRIUM CANCER; FEMALE; GALLBLADDER CANCER; GOLD STANDARD; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; KIDNEY CANCER; LIVER CELL CARCINOMA; LUNG ADENOCARCINOMA; LUNG SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MELANOMA; MESOTHELIOMA; MOLECULAR DIAGNOSIS; MOLECULAR PATHOLOGY; MOLECULAR TUMOR PROFILING; OVARY CANCER; PANCREAS CANCER; PREDICTION; PREDICTIVE VALUE; PRIMARY TUMOR; PRIORITY JOURNAL; PROSTATE CANCER; SARCOMA; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA; STOMACH CANCER; TESTIS CANCER; THYROID CANCER; TUMOR DIFFERENTIATION; UTERINE CERVIX CANCER;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BIOPSY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASMS, UNKNOWN PRIMARY; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL;

EID: 84878859633     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djt099     Document Type: Article

References (20)

1. Greco FA, Hainsworth, JD. Cancer of unknown primary site. In: Devita VT, ed. Cancer: Principles and Practice of Oncology. 9th ed. Philadelphia: Lippincott, Williams and Wilkins; 2011:2033-2051.
2. Bender RA, Erlander MG. Molecular classification of unknown primary cancer. Semin Oncol. 2009;36(1):38-43.
3. Greco FA, Erlander MG. Molecular classification of cancers of unknown primary site. Mol Diagn Ther. 2009;13(6):367-373.
4. Bridgewater J, van Laar R, Floore A, et al. Gene expression profiling may improve diagnosis in patients with carcinoma of unknown primary. Br J Cancer. 2008;98(8):1425-1430. (Pubitemid 351543580)
5. Greco FA, Spigel DR, Yardley DA, et al. Molecular profiling in unknown primary cancer: accuracy of tissue of origin prediction. Oncologist. 2010;15(5):500-506.
6. Hainsworth JD, Pillai R, Henner WD, et al. Molecular tumor profiling in the diagnosis of patients with carcinoma of unknown primary site: retrospective evaluation of gene microarray assay. J Mol Biomark Diagn. 2011;2(2):106-109.
7. Horlings HM, van Laar RK, Kerst JM, et al. Gene expression profiling to identify the histogenetic origin of metastatic adenocarcinomas of unknown primary. J Clin Oncol. 2008;26(27):4435-4441.
8. Varadhachary GR, Talantov D, Raber MN, et al. Molecular profiling of carcinoma of unknown primary and correlation with clinical evaluation. J Clin Oncol. 2008;26(27):4442-4448.
9. Hainsworth JD, Rubin MS, Spigel DR, et al. Molecular gene expression profiling to predict the tissue of origin and direct site-specific therapy in patients with carcinoma of unknown primary site: a prospective trial of the Sarah Cannon Research Institute. J Clin Oncol. 2013;31(2):217-223.
10. Erlander MG, Ma XJ, Kesty NC, et al. Performance and clinical evaluation of the 92-gene real-time PCR assay for tumor classification. J Mol Diagn. 2011;13(5):493-503.
11. Kerr SE, Schnabel CA, Sullivan PS, et al. Multisite validation study to determine performance characteristics of a 92-gene molecular cancer classifier. Clin Cancer Res. 2012;18(14):3952-3960.
12. Ma XJ, Patel R, Wang X, et al. Molecular classification of human cancers using a 92-gene real-time quantitative polymerase chain reaction assay. Arch Pathol Lab Med. 2006;130(4):465-473.
13. Monzon FA, Lyons-Weiler M, Buturovic LJ, et al. Multicenter validation of a 1,550-gene expression profile for identification of tumor tissue of origin. J Clin Oncol. 2009;27(15):2503-2508.
14. Rosenfeld N, Aharonov R, Meiri E, et al. MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol. 2008;26(4):462-469. (Pubitemid 351501813)
15. Talantov D, Baden J, Jatkoe T, et al. A quantitative reverse transcriptasepolymerase chain reaction assay to identify metastatic carcinoma tissue of origin. J Mol Diagn. 2006;8(3):320-329. (Pubitemid 44063808)
16. Oien KA. Pathologic evaluation of unknown primary cancer. Semin Oncol. 2009;36(1):8-37.
17. A'Hern RP. Sample size tables for exact single-stage phase II designs. Stat Med. 2001;20(6):859-866. (Pubitemid 32249085)
18. Pentheroudakis G, Golfinopoulos V, Pavlidis N. Switching benchmarks in cancer of unknown primary: from autopsy to microarray. Eur J Cancer. 2007;43(14):2026-2036. (Pubitemid 47380362)
19. Varadhachary GR, Spector Y, Abbruzzese JL, et al. Prospective gene signature study using microRNA to identify the tissue of origin in patients with carcinoma of unknown primary. Clin Cancer Res. 2011;17(12):4063-4070.
20. Greco FA. Cancer of unknown primary or unrecognized adnexal skin primary carcinoma? Limitations of gene expression profiling diagnosis [published online ahead of print February 26, 2013]. J Clin Oncol. 2013. doi:10.1200/JCO.2012.47. 1615.