Hsps are up-regulated in melanoma tissue and correlate with patient clinical parameters

Cell Stress and Chaperones

Volumn 18, Issue 2, 2013, Pages 145-154

  Shipp, Christopher ^a,b   Weide, Benjamin ^c   Derhovanessian, Evelyna ^a   Pawelec, Graham ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF NEW ENGLAND   (Australia)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Heat shock proteins; Hsps; Immunofluorescence; Metastatic melanoma; Patient clinical parameters; Western immunoblotting

Indexed keywords

CHAPERONIN 60; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEME OXYGENASE 1; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; MALE; MELANOMA CELL; METASTASIS; METASTATIC MELANOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL TIME; UPREGULATION; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; FEMALE; HEAT-SHOCK PROTEINS; HEME OXYGENASE-1; HSP40 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MELANOMA; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; NEOPLASM STAGING; UP-REGULATION;

EID: 84878858528     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-012-0363-1     Document Type: Article

References (39)

1. Andersen MH, Sorensen RB, Brimnes MK, Svane IM, Becker JC, thor Straten P (2009) Identification of heme oxygenase-1-specific regulatory CD8+ T cells in cancer patients. J Clin Invest 119(8):2245-2256
2. Balch CM, Buzaid AC, Soong SJ, Atkins MB, Cascinelli N, Coit DG, Fleming ID, Gershenwald JE, Houghton A Jr, Kirkwood JM, McMasters KM, Mihm MF, Morton DL, Reintgen DS, Ross MI, Sober A, Thompson JA, Thompson JF (2001) Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 19(16):3635-3648
3. Becker B, Multhoff G, Farkas B, Wild PJ, Landthaler M, Stolz W, Vogt T (2004) Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases. Exp Dermatol 13:27-32 (26)
4. Busam KJ, Jungbluth AA (1999) Melan-A, a new melanocytic differentiation marker. Adv Anat Pathol 6(1):12-18
5. Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR (2006) Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci 31(3):164-172
6. Ciocca DR, Calderwood SK (2005) Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperon 10(2):86-103
7. Ciocca DR, Clark GM, Tandon AK, Fuqua SA, Welch WJ, McGuire WL (1993) Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. J Natl Cancer I 85(7):570-574
8. Clinical Trials for HSP (2012) Clinical trials feeds. http://clinicaltrialsfeeds.org/clinical-trials/results/term=HSP?recr=Open. Accessed 25 Jan 2012
9. Deichmann M, Polychronidis M, Benner A, Kleist C, Thome M, Kahle B, Helmke BM (2004) Expression of the heat shock cognate protein HSP73 correlates with tumour thickness of primary melanomas and is enhanced in melanoma metastases. Int J Oncol 25(2):259-268
10. Faingold D, Marshall J-C, Antecka E, Di Cesare S, Odashiro AN, Bakalian S, Fernandes BF, Burnier MN (2008) Immune expression and inhibition of heat shock protein 90 in uveal melanoma. Clin Cancer Res 14(3):847-855
11. Farkas B, Hantschel M, Magyarlaki M, Becker B, Scherer K, Landthaler M, Pfister K, Gehrmann M, Gross C, Mackensen A, Multhoff G (2003) Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma. Melanoma Res 13(2):147-152
12. Flad T, Mueller L, Dihazi H, Grigorova V, Bogumil R, Beck A, Thedieck C, Mueller GA, Kalbacher H, Mueller CA (2006) T cell epitope definition by differential mass spectrometry: identification of a novel, immunogenic HLA-B8 ligand directly from renal cancer tissue. Proteomics 6(1):364-374. doi: 10.1002/pmic.200500099
13. Grbovic OM, Basso AD, Sawai A, Ye Q, Friedlander P, Solit D, Rosen N (2006) V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors. P Natl Acad Sci USA 103(1):57-62
14. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646-674. doi: 10.1016/j.cell.2011.02.013
15. Harada M, Kimura G, Nomoto K (1998) Heat shock proteins and the antitumor T cell response. Biotherapy 10:229-235
16. Jäättelä M, Saksela K, Saksela E (1989) Heat shock protects WEHI-164 target cells from the cytolysis by tumor necrosis factors alpha and beta. Eur J Immunol 19(8):1413-1417. doi: 10.1002/eji.1830190810
17. Jozkowicz A, Was H, Dulak J (2007) Heme oxygenase-1 in tumors: is it a false friend? Antioxid Redox Sign 9(12):2099-2117. doi: 10.1089/ars.2007.1659
18. Kalogeraki A, Garbagnati F, Darivianaki K, Delides GS, Santinami M, Stathopoulos EN, Zoras O (2006) HSP-70, C-myc and HLA-DR expression in patients with cutaneous malignant melanoma metastatic in lymph nodes. Anticancer Res 26(5A):3551-3554
19. Kondo R, Gleixner KV, Mayerhofer M, Vales A, Gruze A, Samorapoompichit P, Greish K, Krauth MT, Aichberger KJ, Pickl WF, Esterbauer H, Sillaber C, Maeda H, Valent P (2007) Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells. Blood 110(2):661-669
20. Lazaris AC, Theodoropoulos GE, Aroni K, Saetta A, Davaris PS (1995) Immunohistochemical expression of C-myc oncogene, heat shock protein 70 and HLA-DR molecules in malignant cutaneous melanoma. Virchows Arch 426(5):461-467
21. Liao D, Luo Y, Markowitz D, Xiang R, Reisfeld RA (2009) Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model. PLoS ONE 4(11):e7965
22. Lucas R, McMichael T, Smith W, Armstrong B (2006) Solar ultraviolet radiation - global burden of disease from solar ultraviolet radiation. World Health Organization, Geneva
23. Maines MD, Abrahamsson PA (1996) Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution. Urology 47(5):727-733
24. McCarthy MM, Pick E, Kluger Y, Gould-Rothberg B, Lazova R, Camp RL, Rimm DL, Kluger HM (2008) HSP90 as a marker of progression in melanoma. Ann Oncol 19(3):590-594
25. Melcher A, Murphy S, Vile R (1999) Heat shock protein expression in target cells infected with low levels of replication-competent virus contributes to the immunogenicity of adenoviral vectors. Hum Gene Ther 10(9):1431-1442
26. Missotten GS, Journée-de Korver JG, Wolff-Rouendaal D, Keunen JE, Schlingemann RO, Jager MJ (2003) Heat shock protein expression in the eye and in uveal melanoma. Invest Ophth Vis Sci 44:3059-3065
27. Multhoff G, Botzler C, Jennen L, Schmidt J, Ellwart J, Issels R (1997) Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells. J Immunol 158(9):4341-4350
28. Neckers L (2007) Heat shock protein 90: the cancer chaperone. J Bioscience 32(3):517-530
29. Noessner E, Gastpar R, Milani V, Brandl A, Hutzler PJ, Kuppner MC, Roos M, Kremmer E, Asea A, Calderwood SK, Issels RD (2002) Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells. J Immunol 169(10):5424-5432
30. Pick E, Kluger Y, Giltnane JM, Moeder C, Camp RL, Rimm DL, Kluger HM (2007) High HSP90 expression is associated with decreased survival in breast cancer. Cancer Res 67(7):2932-2937
31. Ricaniadis N, Kataki A, Agnantis N, Androulakis G, Karakousis CP (2001) Long-term prognostic significance of HSP-70, c-myc and HLA-DR expression in patients with malignant melanoma. Eur J Surg Oncol 27:88-93
32. STA-9090 in Metastatic Ocular Melanoma (2011) Clinical trials feeds. http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01200238. Accessed 14 June 2011
33. Wandinger SK, Richter K, Buchner J (2008) The Hsp90 chaperone machinery. J Biol Chem 283(27):18473-18477
34. Was H, Cichon T, Smolarczyk R, Rudnicka D, Stopa M, Chevalier C, Leger JJ, Lackowska B, Grochot A, Bojkowska K, Ratajska A, Kieda C, Szala S, Dulak J, Jozkowicz A (2006) Overexpression of heme oxygenase-1 in murine melanoma: increased proliferation and viability of tumor cells, decreased survival of mice. Am J Pathol 169(6):2181-2198. doi: 10.2353/ajpath.2006.051365
35. Wells AD, Rai SK, Salvato MS, Band H, Malkovsky M (1997) Restoration of MHC class I surface expression and endogenous antigen presentation by a molecular chaperone. Scand J Immunol 45(6):605-612
36. Wells AD, Rai SK, Salvato MS, Band H, Malkovsky M (1998) Hsp72-mediated augmentation of MHC class I surface expression and endogenous antigen presentation. Int Immunol 10:609-617
37. Westekemper H, Karimi S, Süsskind D, Anastassiou G, Freistühler M, Steuhl K-P, Bornfeld N, Schmid K-W, Grabellus F (2011) Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma. Brit J Ophthalmol 95:853-858
38. Whitesell L, Lindquist SL (2005) HSP90 and the chaperoning of cancer. Nat Rev Cancer 5(10):761-772
39. WHO (2008) World cancer report 2008. International Agency for Research on Cancer, Geneva