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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 13, 2013, Pages 3857-3863

Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2

(9) Sifferlen, Thierry a Koberstein, Ralf a Cottreel, Emmanuelle a Boller, Amandine a Weller, Thomas a Gatfield, John a Brisbare Roch, Catherine a Jenck, Francois a Boss, Christoph a

a ACTELION PHARMACEUTICALS LTD (Switzerland)

Author keywords

G protein coupled receptors; Neuropeptides; Orexin receptors; Sleep 5,6,7,8 Tetrahydroimidazo 1,5 a pyrazine

Indexed keywords

PYRAZINE DERIVATIVE; RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ELECTROENCEPHALOGRAPHY; IC 50; NONHUMAN; RAT; SLEEP; STRUCTURE ACTIVITY RELATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMIDAZOLES; MOLECULAR STRUCTURE; OREXIN RECEPTORS; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84878852299 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.04.071 Document Type: Article

Times cited : (14)

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