Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 13, 2013, Pages 3927-3934

  Mazurov, Anatoly A ^a   Kombo, David C ^a   Akireddy, Srinivasa ^a   Murthy, Srinivasa ^a   Hauser, Terry A ^a   Jordan, Kristen G ^a   Gatto, Gregory J ^a   Yohannes, Daniel ^a  

^a TARGACEPT INC   (United States)

Author keywords

3,7 Diazabicyclo 3.3.0 octane; 3,7 Diazabicyclo 3.3.1 nonane; 3 Azabicyclo 3.3.0 octane; 3 Azabicyclo 3.3.1 nonane; Hydrogen bond acceptor; Nicotinic acetylcholine receptor; Novel object recognition; Selective nAChR agonist

Indexed keywords

3 PROPIONYL 3,7 DIAZABICYCLO[3.3.0]OCTANE; BICYCLO[3.3.0]OCTANE DERIVATIVE; CARBONYL DERIVATIVE; HYDROGEN; LIGAND; NICOTINE; NICOTINIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; CYCLIZATION; DRUG RECEPTOR BINDING; HYDROGEN BOND; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; RAT; RECOGNITION; TASK PERFORMANCE; WORKING MEMORY;

HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDINES; RECEPTORS, NICOTINIC;

EID: 84878844171     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.058     Document Type: Article

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