SLC2A4gene: A promising target for pharmacogenomics of insulin resistance

Pharmacogenomics

Volumn 14, Issue 8, 2013, Pages 847-850

  Corrêa Giannella, Maria Lucia ^a   MacHado, Ubiratan F ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

diabetes; GLUT4; insulin resistance; pharmacogenomics; SLC2A4

Indexed keywords

GLUCOSE TRANSPORTER 4; HEMOGLOBIN A1C; MESSENGER RNA;

ADIPOSE TISSUE; DIABETES MELLITUS; GENE EXPRESSION; GENE TRANSLOCATION; GENETIC ASSOCIATION; GENOTYPE; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; GLYCEMIC CONTROL; HOMOZYGOTE; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PHARMACOGENOMICS; PROTEIN EXPRESSION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SKELETAL MUSCLE; SLC2A4 GENE;

DIABETES MELLITUS; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN RESISTANCE; MOLECULAR TARGETED THERAPY; OBESITY; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84878834897     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.13.45     Document Type: Review

References (20)

1. Okamoto MM, Anhê GF, Sabino-Silva R et al. Intensive insulin treatment induces insulin resistance in diabetic rats by impairing glucose metabolism-related mechanisms in muscle and liver. J. Endocrinol. 211(1), 55-64 (2011).
2. Machado UF, Shimizu I, Saito M. Reduced content and preserved translocation of glucose transporter (GLUT 4) in white adipose tissue of obese mice. Physiol. Behav. 55(4), 621-625 (1994). (Pubitemid 24104386)
3. Marsh BJ, Martin S, Melvin DR et al. Mutational analysis of the carboxy-terminal phosphorylation site of GLUT-4 in 3T3-L1 adipocytes. Am. J. Physiol. 275(3), E412-E422 (1998).
4. Zaarour N, Berenguer M, Le Marchand-Brustel Y, Govers R. Deciphering the role of GLUT4 N-glycosylation in adipocyte and muscle cell models. Biochem. J. 445(2), 265-273 (2012).
5. Herman MA, Kahn BB. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J. Clin. Invest. 116(7), 1767-1775 (2006). (Pubitemid 44033296)
6. Seraphim PM, Nunes MT, Machado UF. GLUT4 protein expression in obese and lean 12-month-old rats: insights from different types of data analysis. Braz. J. Med. Biol. Res. 34(10), 1353-1362 (2001). (Pubitemid 33014506)
7. Machado UF, Shimizu Y, Saito M. Decreased glucose transporter (GLUT 4) content in insulin-sensitive tissues of obese aurothioglucose-and monosodium glutamate-treated mice. Horm. Metab. Res. 25(9), 462-465 (1993). (Pubitemid 23274566)
8. de Carvalho Papa P, Vargas AM, da Silva JL, Nunes MT, Machado UF. GLUT4 protein is differently modulated during development of obesity in monosodium glutamate-treated mice. Life Sci. 71(16), 1917-1928 (2002). (Pubitemid 34880236)
9. Zisman A, Peroni OD, Abel ED et al. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat. Med. 6(8), 924-9928 (2000).
10. Gibbs EM, Stock JL, McCoid SC et al. Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J. Clin. Invest. 95(4), 1512-1518 (1995).
11. Bodhini D, Radha V, Ghosh S, Majumder PP, Rao MR, Mohan V. GLUT4 gene polymorphisms and their association with Type 2 diabetes in south Indians. Diabetes Technol. Ther. 13(9), 913-920 (2011).
12. Kissebah AH, Sonnenberg GE, Myklebust J et al. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc. Natl Acad. Sci. USA 97(26), 14478-14483 (2000). (Pubitemid 32016601)
13. Choi WH, O'Rahilly S, Buse JB et al. Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects. Diabetes 40(12), 1712-1718 (1991).
14. Lesage S, Zouali H, Vionnet N et al. Genetic analyses of glucose transporter genes in French non-insulin-dependent diabetic families. Diabetes Metab. 23(2), 137-142 (1997). (Pubitemid 27154196)
15. Friedel S, Antwerpen B, Hoch A et al. Glucose transporter 4 gene: association studies pertaining to alleles of two polymorphisms in extremely obese children and adolescents and in normal and underweight controls. Ann. NY Acad. Sci. 967, 554-557 (2002). (Pubitemid 34721946)
16. Haygood R, Fedrigo O, Hanson B, Yokoyama KD, Wray GA. Promoter regions of many neural-and nutrition-related genes have experienced positive selection during human evolution. Nat. Genet. 39(9), 1140-1144 (2007). (Pubitemid 47340653)
17. Tarazona-Santos E, Fabbri C, Yeager M et al. Diversity in the glucose transporter-4 gene (SLC2A4) in humans reflects the action of natural selection along the old-world primates evolution. PLoS ONE 5(3), 1-10 (2010).
18. Xia X, Hu Y, Xu L, Chen T. A functional promoter polymorphism of SLC2A4 is associated with aerobic endurance in a Chinese population. Eur. J. Sport Sci. 2012, 1-7 (2012).
19. Xi C, Miyaki K, Ikeda S, Song Y, Sinbo T, Muramatsu M. Association of GLUT4 gene variants with HbA1c level in Japanese men. Endocr. J. 59(8), 677-684 (2012).
20. Bjørbaek C, Echwald SM, Hubricht P et al. Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM. Diabetes 43(8), 976-983 (1994). (Pubitemid 24230700)