Effects on transthyretin in plasma and cerebrospinal fluid by dha-rich n-3 fatty acid supplementation in patients with alzheimer's disease: the omegad study

Journal of Alzheimer's Disease

Volumn 36, Issue 1, 2013, Pages 1-6

  Faxén Irving, Gerd ^a   Freund Levi, Yvonne ^a   Eriksdotter Jönhagen, Maria ^a   Basun, Hans ^b   Hjorth, Erik ^a   Palmblad, Jan ^a   Vedin, Inger ^a   Cederholm, Tommy ^b   Wahlund, Lars Olof ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alzheimer's disease; dementia; fatty acids; transthyretin

Indexed keywords

APOLIPOPROTEIN E4; C REACTIVE PROTEIN; DOCOSAHEXAENOIC ACID; EPAX 1050TG; ICOSAPENTAENOIC ACID; PLACEBO; PREALBUMIN; SERUM ALBUMIN; UNCLASSIFIED DRUG;

AGE; AGED; ALBUMIN BLOOD LEVEL; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; OUTPATIENT CARE; PATIENT COMPLIANCE; PLASMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION;

EID: 84878830398     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-121828     Document Type: Article

References (15)

1. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356.
2. Hansson SF, Andréasson U, Wall M, Skoog I, Andreasen N, Wallin A, Zetterberg H, Blennow K (2009) Reduced levels of amyloid-binding proteins in cerebrospinal fluid from Alzheimer's disease patients. J Alzheimers Dis 16, 389-397.
3. LimGP, Calon F, MoriharaT,Yang F,Teter B, Ubeda O, Salem N, Frautschy SA, Cole GM (2005) A diet enriched with the omega-3 fatty acid docosoahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci 25, 3032-3040.
4. Lim WS, Gammack JK, Van Niekerk JK, Dangour A (2006) Omega 3 fatty acid for the prevention of dementia. Cochrane Database Syst Rev, Issue 1. [DOI: 10.1002/14651858.CD00 5379.pub2]
5. Soderberg M, Edlund C, Kristensson K, Dallner G (1991) Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids 26, 421-425.
6. Puskas LG, Kitajka K, Nyakas C, Barcelo-Coblijn G, FarkasT (2003) Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus. Proc Natl Acad Sci U S A 100, 1580-1585.
7. Freund-Levi Y, Eriksdotter-Jönhagen M, Cederholm T, Basun H, Faxén-Irving G, Garlind A, Vedin I, Vessby B, Wahlund LO, Palmblad J (2006) Omega 3 fatty acid treatment in174 patients with mild to moderate Alzheimer's disease:OmegAD Study. Arch Neurol 63, 1402-1408.
8. Bang P, Eriksson U, SaraV,Wivall IL, HallK(1991) Comparison of acid ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays: Improvement of determinations in acid ethanol extracts by the use of truncated IGF-I as radioligand. Acta Endocrinol (Copenhagen) 124, 620-629.
9. Faxén-Irving G, Freund-Levi Y, Eriksdotter-Jönhagen M, Basun H, Brismar K, Hjorth E, Palmblad J, Vessby B, Vedin I, Wahlund L-O, Cederholm T (2009) N-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: The OmegAD study. J Am Geriatr Soc 57, 11-17.
10. Gloeckner SF, Meyne F, Wagner F, Heinemann U, Krasnianski A, Meissner B, Zerr I (2008) Quantitative analysis of transthyretin, tau and amyloid-in patients with dementia. J Alzheimers Dis 14, 17-25.
11. Riisoen (1988) Reduced prealbumin (transthyretin) in CSF of severely demented patients with Alzheimer's disease. Acta Neurol Scand 78, 455-459.
12. Aleshire SL, Bradley CA, Richardson LD, Parl FF (1983) Localization of human prealbumin in choroid plexus epithelium. J Histochem Cytochem 31, 608-612.
13. Dickson PW, Aldred AR, Marley PD, Bannister D, Schreiber G (1986) Rat choroid plexus specializes in the synthesis and the secretion of transthyretin (prealbumin): Regulation of transthyretin synthesis in choroid plexus is independent from that in liver. J Biol Chem 261, 3475-3478.
14. Kitajka K, Puskas LG, Zvara A, Hackler L, Barcelo-Coblijn G, Yeo YK, Farkas T (2002) The role of n-3 polyunsaturated fatty acids in brain: Modulation of rat brain gene expression by dietary n-3 fatty acids. Proc Natl Acad Sci U S A 99, 2619-2624.
15. Hilding A, Hall K, Wivall-Hilleryd IL, Sääf M, Melin AL, Thorén M (1999) Serum levels of insulin-like growth factor I (IGF-I) in 152 patients with growth hormone (GH) deficiency aged 19-82 years in relation to healthy subjects. J Clin Endocrinol Metab 84, 2013-2019.