Columnar cell variant of papillary thyroid carcinoma: A study of 10 cases with emphasis on CDX2 expression

Thyroid

Volumn 23, Issue 6, 2013, Pages 714-719

  Sujoy, Victoria ^a   Pinto, André ^a   Nosé, Vânia ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BETA CATENIN; KI 67 ANTIGEN; THYROID TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR CDX2; BIOLOGICAL MARKER; CDX2 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; TUMOR PROTEIN;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CELL VACUOLE; CLINICAL ARTICLE; CLINICAL FEATURE; COLUMNAR CELL VARIANT OF PAPILLARY THYROID CARCINOMA:; CYTOLOGY; FEMALE; GENE MUTATION; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH VESSEL METASTASIS; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID CARCINOMA; WORLD HEALTH ORGANIZATION; CARCINOMA; CELL NUCLEUS; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; THYROID GLAND; THYROID NEOPLASMS; TREATMENT OUTCOME; TUMOR VOLUME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CARCINOMA; CELL NUCLEUS; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; THYROID GLAND; THYROID NEOPLASMS; TREATMENT OUTCOME; TUMOR BURDEN;

EID: 84878819160     PISSN: 10507256     EISSN: 15579077     Source Type: Journal    
DOI: 10.1089/thy.2012.0455     Document Type: Article

References (23)

1. Sujoy V, Pinto A, Kovacs CM, Nosé V 2011 CDX2 is rarely expressed in columnar cell variant of papillary thyroid carcinoma: a study of ten cases. Mod Pathol 24(S1):142A.
2. DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds) 2004 World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Organs. IARC Press, Lyon, France.
3. Chen JH, Faquin WC, Lloyd RV, Nosé V 2011 Clinicopathologic and molecular characterization of nine cases of columnar cell variant of papillary thyroid carcinoma. Mod Pathol 24:739-749.
4. Silver CE, Owen RP, Rodrigo JP, Rinaldo A, Devaney KO, Ferlito A 2011 Aggressive variants of papillary thyroid carcinoma. Head Neck 33:1052-1059.
5. Albores-Saavedra J, Wu J 2006 The many faces and mimics of papillary thyroid carcinoma. Endocr Pathol 17:1-18.
6. Mazziotta, RM, Borczuk AC, Powell CA, Mansukhani M 2005 CDX2 immunostaining as a gastrointestinal marker. Expression in lung carcinomas as a potential pitfall. Appl Immunohistochem Mol Morphol 13:55-60.
7. Evans HL 1986 Columnar-cell carcinoma of the thyroid. A report of two cases of an aggressive variant of thyroid carcinoma. Am J Clin Pathol 85:77-80.
8. Berends D, Mouthaan PJ 1992 Columnar-cell carcinoma of the thyroid. Histopathology 20:360-362.
9. Schmidt J, Derr V, Heinrich MC, Crum CP, Fletcher JA, Corless CL, Nosé V 2007 BRAF in papillary thyroid carcinoma of ovary (struma ovarii). Am J Surg Pathol 31:1337-1343.
10. Jin L, Sebo TJ, Nakamura N, Qian X, Oliveira A, Majerus JA, Johnson MR, Lloyd RV 2006 BRAF mutation analysis in fine needle aspiration (FNA) cytology of the thyroid. Diagn Mol Pathol 15:136-143.
11. Jin L, Sebo TJ, Nakamura N, Qian X, Oliveira A, Majerus JA, Johnson MR, Lloyd RV 2005 RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors. Lab Invest 85:1065-1075.
12. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A (eds) 2010 AJCC Cancer Staging Manual, 7th ed. Springer, New York.
13. Asioli S, Erickson LA, Sebo TJ, Zhang J, Jin L, Thompson GB, Lloyd RV 2010 Papillary thyroid carcinoma with prominent hobnail features: a new aggressive variant of moderately differentiated papillary carcinoma. A clinicopathologic, immunohistochemical, and molecular study of eight cases. Am J Surg Pathol 34:44-52.
14. Wenig BM, Thompson LD, Adair CF, Shmookler B, Heffess CS 1998 Thyroid papillary carcinoma of columnar cell type. A clinicopathologic study of 16 cases. Cancer 82:740-753.
15. Sywak M, Pasieka JL, Ogilvie T 2004 A review of thyroid cancer with intermediate differentiation. J Surg Oncol 86: 44-54.
16. Hirokawa M, Shimizu M, Fukuya T, Manabe T, Sonoo H 1998 Columnar cell carcinoma of the thyroid: MIB-1 immunoreactivity as a prognostic factor. Endocr Pathol 9: 31-34.
17. Tallini G, Garcia-Rostan G, Herrero A, Zelterman D, Viale G, Bosari S, Carcangiu ML 1999 Downregulation of p27KIP1 and Ki67/Mib1 labeling index support the classification of thyroid carcinoma into prognostically relevant categories. Am J Surg Pathol 23:678-685.
18. Zhang J, Gill AJ, Issacs JD, Atmore B, Johns A, Delbridge LW, Lai R, McMullen TP 2012 The Wnt/beta-catenin pathway drives increased cyclin D1 levels in lymph node metastasis in papillary thyroid cancer. Hum Pathol 43:1044-1050.
19. Lantsov D, Meirmanov S, Nakashima M, Kondo H, Saenko V, Naruke Y, Namba H, Ito M, Abrosimov A, Lushnikov E, Sekine I, Yamashita Sh 2005 Cyclin D1 overexpression in thyroid papillary microcarcinoma: its association with tumour size and aberrant beta-catenin expression. Histopathology 47:248-256.
20. Barbareschi M, Murer B, Colby TV, Chilosi M, Macri E, Loda M, Doglioni C 2003 CDX2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs. Am J Surg Pathol 27:141-149.
21. Werling RW, Yaziji H, Bacchi CE, Gown AM 2003 CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol 27:303-310.
22. Lee MJ, Vogt AP, Hsiao W, Osunkoya AO 2012 CDX-2 expression in malignant germ cell tumors of the testes, intratubular germ cell neoplasia, and normal seminiferous tubules. Tumour Biol 33:2185-2188.
23. Enriquez ML, Baloch ZW, Montone KT, Zhang PJ, Livolsi VA 2012 CDX2 expression in columnar cell variant of papillary thyroid carcinoma. Am J Clin Pathol 137:722-726.