Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers

Molecular Cancer

Volumn 12, Issue 1, 2013, Pages

  Oshima, Tsutomu ^a   Sato, Shuji ^a   Kato, Junichi ^a   Ito, Yuki ^a   Watanabe, Takahiro ^a   Tsuji, Isamu ^a   Hori, Akira ^a   Kurokawa, Tomofumi ^a   Kokubo, Toshio ^a,b  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Antibody; Antibody dependent cellular cytotoxicity; Cancer; Nectin 2

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY Y 187; MONOCLONAL ANTIBODY Y 443; NECTIN 1; NECTIN 2; NECTIN 3; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CANCER TISSUE; CELL SURFACE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVARY CANCER; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; EPITOPES; FEMALE; GENE EXPRESSION; HUMANS; MICE; OVARIAN NEOPLASMS; PROTEIN BINDING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ORYCTOLAGUS CUNICULUS;

EID: 84878815168     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-60     Document Type: Article

References (29)

1. Takai Y, Nakanishi H. Nectin and afadin: novel organizers of intercellular junctions. J Cell Sci 2003, 116:17-27. 10.1242/jcs.00167, 12456712.
2. Momose Y, Honda T, Inagaki M, Shimizu K, Irie K, Nakanishi H, Takai Y. Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion. Biochem Biophys Res Commun 2002, 293:45-49. 10.1016/S0006-291X(02)00183-3, 12054561.
3. Satoh-Horikawa K, Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K, Mizoguchi A, Takai Y. Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem 2000, 275:10291-10299. 10.1074/jbc.275.14.10291, 10744716.
4. Miyahara M, Nakanishi H, Takahashi K, Satoh-Horikawa K, Tachibana K, Takai Y. Interaction of nectin with afadin is necessary for its clustering at cell-cell contact sites but not for its cis dimerization or trans interaction. J Biol Chem 2000, 275:613-618. 10.1074/jbc.275.1.613, 10617658.
5. Yasumi M, Shimizu K, Honda T, Takeuchi M, Takai Y. Role of each immunoglobulin-like loop of nectin for its cell-cell adhesion activity. Biochem Biophys Res Commun 2003, 302:61-66. 10.1016/S0006-291X(03)00106-2, 12593848.
6. Lopez M, Aoubala M, Jordier F, Isnardon D, Gomez S, Dubreuil P. The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule. Blood 1998, 92:4602-4611.
7. Fabre S, Reymond N, Cocchi F, Menotti L, Dubreuil P, Campadelli-Fiume G, Lopez M. Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C" -D beta-strands of the nectin1 V domain. J Biol Chem 2002, 277:27006-27013. 10.1074/jbc.M203228200, 12011057.
8. Reymond N, Fabre S, Lecocq E, Adelaide J, Dubreuil P, Lopez M. Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. J Biol Chem 2001, 276:43205-43215. 10.1074/jbc.M103810200, 11544254.
9. Fukuhara A, Irie K, Yamada A, Katata T, Honda T, Shimizu K, Nakanishi H, Takai Y. Role of nectin in organization of tight junctions in epithelial cells. Genes Cells 2002, 7:1059-1072. 10.1046/j.1365-2443.2002.00578.x, 12354099.
10. Fukuhara A, Irie K, Nakanishi H, Takekuni K, Kawakatsu T, Ikeda W, Yamada A, Katata T, Honda T, Sato T, Shimizu K, Ozaki H, Horiuchi H, Kita T, Takai Y. Involvement of nectin in the localization of junctional adhesion molecule at tight junctions. Oncogene 2002, 21:7642-7655. 10.1038/sj.onc.1205875, 12400007.
11. Fukuhara A, Shimizu K, Kawakatsu T, Fukuhara T, Takai Y. Involvement of nectin-activated Cdc42 small G protein in organization of adherens and tight junctions in Madin-Darby canine kidney cells. J Biol Chem 2003, 278:51885-51893. 10.1074/jbc.M308015200, 14530286.
12. Morita H, Nandadasa S, Yamamoto TS, Terasaka-Iioka C, Wylie C, Ueno N. Nectin-2 and N-cadherin interact through extracellular domains and induce apical accumulation of F-actin in apical constriction of Xenopus neural tube morphogenesis. Development 2010, 137:1315-1325. 10.1242/dev.043190, 2847467, 20332149.
13. Bouchard MJ, Dong Y, McDermott BM, Lam DH, Brown KR, Shelanski M, Bellve AR, Racaniello VR. Defects in nuclear and cytoskeletal morphology and mitochondrial localization in spermatozoa of mice lacking nectin-2, a component of cell-cell adherens junctions. Mol Cell Biol 2000, 20:2865-2873. 10.1128/MCB.20.8.2865-2873.2000, 85510, 10733589.
14. Mizoguchi A, Nakanishi H, Kimura K, Matsubara K, Ozaki-Kuroda K, Katata T, Honda T, Kiyohara Y, Heo K, Higashi M, Tsutsumi T, Sonoda S, Ide C, Takai Y. Nectin: an adhesion molecule involved in formation of synapses. J Cell Biol 2002, 156:555-565. 10.1083/jcb.200103113, 2173327, 11827984.
15. Inagaki M, Irie K, Deguchi-Tawarada M, Ikeda W, Ohtsuka T, Takeuchi M, Takai Y. Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus. J Comp Neurol 2003, 460:514-524. 10.1002/cne.10653, 12717711.
16. Warner MS, Geraghty RJ, Martinez WM, Montgomery RI, Whitbeck JC, Xu R, Eisenberg RJ, Cohen GH, Spear PG. A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus. Virology 1998, 246:179-189. 10.1006/viro.1998.9218, 9657005.
17. Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med 2003, 198:557-567. 10.1084/jem.20030788, 2194180, 12913096.
18. Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). Int Immunol 2004, 16:533-538. 10.1093/intimm/dxh059, 15039383.
19. Stanietsky N, Simic H, Arapovic J, Toporik A, Levy O, Novik A, Levine Z, Beiman M, Dassa L, Achdout H, Stern-Ginossar N, Tsukerman P, Jonjic S, Mandelboim O. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci USA 2009, 106:17858-17863. 10.1073/pnas.0903474106, 2764881, 19815499.
20. Chan CJ, Andrews DM, Smyth MJ. Receptors that interact with nectin and nectin-like proteins in the immunosurveillance and immunotherapy of cancer. Curr Opin Immunol 2012, 24:246-251. 10.1016/j.coi.2012.01.009, 22285893.
21. Aoki J, Koike S, Asou H, Ise I, Suwa H, Tanaka T, Miyasaka M, Nomoto A. Mouse homolog of poliovirus receptor-related gene 2 product, mPRR2, mediates homophilic cell aggregation. Exp Cell Res 1997, 235:374-384. 10.1006/excr.1997.3685, 9299162.
22. Delboy MG, Patterson JL, Hollander AM, Nicola AV. Nectin-2-mediated entry of a syncytial strain of herpes simplex virus via pH-independent fusion with the plasma membrane of Chinese hamster ovary cells. Virol J 2006, 3:105. 10.1186/1743-422X-3-105, 1779275, 17192179.
23. Tomizuka K, Shinohara T, Yoshida H, Uejima H, Ohguma A, Tanaka S, Sato K, Oshimura M, Ishida I. Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies. Proc Natl Acad Sci USA 2000, 97:722-727. 10.1073/pnas.97.2.722, 15397, 10639146.
24. Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 2000, 6:443-446. 10.1038/74704, 10742152.
25. Steplewski Z, Sun LK, Shearman CW, Ghrayeb J, Daddona P, Koprowski H. Biological activity of human-mouse IgG1, IgG2, IgG3, and IgG4 chimeric monoclonal antibodies with antitumor specificity. Proc Natl Acad Sci USA 1988, 85:4852-4856. 10.1073/pnas.85.13.4852, 280534, 3387441.
26. Tao MH, Canfield SM, Morrison SL. The differential ability of human IgG1 and IgG4 to activate complement is determined by the COOH-terminal sequence of the CH2 domain. J Exp Med 1991, 173:1025-1028. 10.1084/jem.173.4.1025, 2190803, 2007852.
27. Castriconi R, Dondero A, Corrias MV, Lanino E, Pende D, Moretta L, Bottino C, Moretta A. Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction. Cancer Res 2004, 64:9180-9184. 10.1158/0008-5472.CAN-04-2682, 15604290.
28. Pende D, Spaggiari GM, Marcenaro S, Martini S, Rivera P, Capobianco A, Falco M, Lanino E, Pierri I, Zambello R, Bacigalupo A, Mingari MC, Moretta A, Moretta L. Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). Blood 2005, 105:2066-2073. 10.1182/blood-2004-09-3548, 15536144.
29. Tahara-Hanaoka S, Shibuya K, Kai H, Miyamoto A, Morikawa Y, Ohkochi N, Honda S, Shibuya A. Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor. Blood 2006, 107:1491-1496. 10.1182/blood-2005-04-1684, 16249389.