WNT3A modulates chondrogenesis via canonical and non-canonical Wnt pathways in MSCs

Frontiers in Bioscience

Volumn 18, Issue 2, 2013, Pages 493-503

  Qu, Feng ^a,b   Wang, Junliang ^b   Xu, Ningru ^a   Liu, Chang ^b   Li, Shuyuan ^b   Wang, Ning ^b   Qi, Wei ^b   Li, Haifeng ^b   Li, Chunbao ^b   Geng, Zhenying ^a   Liu, Yujie ^b  

^a NANKAI UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Adult; Articular; Chondrocytes; Human; Induced; Mesenchymal; Pluripotent; Stem Cells; Wnt3A

Indexed keywords

DKK1 PROTEIN, HUMAN; SIGNAL PEPTIDE; WNT3A PROTEIN;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CHONDROGENESIS; DRUG EFFECT; MALE; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; RAT; WNT SIGNALING PATHWAY;

ANIMALS; CELL DIFFERENTIATION; CHONDROGENESIS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MESENCHYMAL STROMAL CELLS; RATS; WNT SIGNALING PATHWAY; WNT3A PROTEIN;

MLCS; MLOWN;

EID: 84878784650     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4116     Document Type: Article

References (49)

1. Palmer GD, Steinert A, Pascher A, Gouze E, Gouze J,Betz O, Johnstone B,Evans CH, and Ghivizzani SC. Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro. Mol Ther 12, 219-228. (2005) (Pubitemid 41025091)
2. Caplan A I, and Bruder SP: Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med 7, 259-264. (2001) (Pubitemid 32545522)
3. Richter W: Cell-based cartilage repair: illusion or solution for osteoarthritis. Curr Opin Rheumatol 19, 451-456. (2007) (Pubitemid 47344237)
4. Vinatier C, Gauthier O, Masson M, Malard O, Moreau A, Fellah BH, Bilban M, Spaethe R, Daculsi G, and Guicheux J: Nasal chondrocytes and fibrin sealant for cartilage tissue engineering. J Biomed Mater Res A 89, 176-185. (2009)
5. Takahashi K, Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676. (2006) (Pubitemid 44233629)
6. Selvaraj V, Plane JM, Williams AJ, Deng W: Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies. Trends in Biotechnology 28, 214-223 (2010)
7. Zhao XY, Li Wei, Lv Zhuo, Liu Lei, Tong Man, Hai Tang, Hao Jie, Guo Chang-Long: iPS cells produce viable mice through tetraploid complementation. Nature 461, 86-90. (2009)
8. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM: Blastocysts Embryonic Stem Cell Lines Derived from Human. Science 282, 1145-1147. (1998) (Pubitemid 28516247)
9. Barrilleaux B, Phinney DG, Prockop DJ, O'Connor KC: Review: ex vivo engineering of living tissues with adult stem cells. Tissue Eng 12, 3007-3019 (2006) (Pubitemid 44846407)
10. Gimble JM, Katz AJ, Bunnell BA: Adipose-derived stem cells for regenerative medicine. Circ Res 100, 1249-1260. (2007) (Pubitemid 46742916)
11. Liao YH, Verchere CB, Warnock GL: Adult stem or progenitor cells in treatment for type 1 diabetes: current progress. Can J Surg 50,137-142. (2007)
12. Mimeault M, Hauke R, Batra SK: Stem Cells: A Revolution in Therapeutics-Recent Advances in Stem Cell Biology and Their Therapeutic Applications in Regenerative Medicine and Cancer Therapies. Clin Pharmacol Ther 82, 252-264. (2007) (Pubitemid 47260547)
13. Christoforou N, Gearhart JD: Stem Cells and Their Potential in Cell-Based Cardiac Therapies. Prog Cardiovasc Dis 49, 396-413. (2007) (Pubitemid 46693944)
14. Le Blanc K, Ringdén O: Mesenchymal stem cells: properties and role in clinical bone marrow transplantation. Curr Opin Immunol 18, 586-591. (2006) (Pubitemid 44311450)
15. Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 213, 341-347 (2007) (Pubitemid 47509711)
16. Ashton BA, Allen TD, Howlett CR, Eaglesom CC, Hattori A, and Owen M: Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo. Clin Orthop 151, 294-307 (1980)
17. Haynesworth SE, Goshima J, Goldberg VM, and Caplan AI: Characterization of cells with osteogenic potential from human marrow. Bone 13: 81-88. (1992)
18. Prockop DJ: Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276: 71-74. (1997) (Pubitemid 27161245)
19. Phinney DG, Prockop DJ: Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells. 25: 2896-2902 (2007) (Pubitemid 350127874)
20. Chanda D, Kumar S, Ponnazhagan S: Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton. J Cell Biochem 111:249-257. (2010)
21. Du SJ, Purcell SM, Christian JL, McGrew LL, Moon RT: Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos. Mol Cell Biol 15:2625-2634. (1995)
22. Kuhl M, Sheldahl LC, Park M, Miller JR, Moon RT: The Wnt/Ca2t pathway: A new vertebrate Wnt signaling pathway takes shape. Trends Genet 16,279-283 (2000) (Pubitemid 30389591)
23. Komiya Y, Habas R: Wnt signal transduction pathways. Organogenesis 42:68-75. (2008) (Pubitemid 351881302)
24. Miller JR, Hocking AM, Brown JD, Moon RT: Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways. Oncogene 1855, 7860-7872. (1999) (Pubitemid 30066232)
25. Logan CY, and Nusse R: The Wnt signaling pathway in development and disease: Annu Rev Cell Dev Biol 20, 781-810. (2004) (Pubitemid 39488658)
26. Moon RT, Kohn AD, De Ferrari GV, Kaykas A: WNT and beta-catenin signalling: Diseases and therapies. Nat Rev Genet 5:691-701. (2004) (Pubitemid 39150127)
27. Murdoch B, Chadwick K, Martin M, Shojaei F, Shah KV, Gallacher L, Moon RT, Bhatia M: Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci USA100:3422-3427. (2003) (Pubitemid 36356599)
28. Kawano Y, Kypta R: Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116, 2627-2634. (2003) (Pubitemid 36857216)
29. Nelson WJ, Nusse R: Convergence of Wnt, betacatenin, and cadherin pathways. Science 303, 1483-1487. (2004) (Pubitemid 38314410)
30. Macdonald BT, Semenov MV, and He X: SnapShot: Wnt/beta-catenin signaling. Cell 131, 1204.e1-1204.e2. (2007)
31. Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, and Dell'accio F: WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. J Cell Biol 193, 551-564. (2011)
32. Semenov MV, Habas R, Macdonald BT, and He X: SnapShot: noncanonical Wnt signaling pathways: Cell 131, 1378.e1-1378.e2. (2007)
33. Church V, Nohno T, Linker C, Marcelle C, and Francis-West P: Wnt regulation of chondrocyte differentiation. J Cell Sci 115, 4809-4818. (2002) (Pubitemid 36054634)
34. Akiyama, H, Lyons JP, Mori-Akiyama Y, Yang X, Zhang R, Zhang Z, Deng JM, Taketo MM, Nakamura T, Behringer RR: Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev 18, 1072-1087. (2004) (Pubitemid 38620246)
35. Lories RJ, Peeters J, Bakker A, Tylzanowski P, Derese I, Schrooten J, Thomas JT, and Luyten FP: Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum 56, 4095-4103. (2007) (Pubitemid 350262337)
36. Chen M, Zhu M, Awad H, Li TF, Sheu TJ, Boyce BF, Chen D, and O'Keefe RJ: Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. J Cell Sci 121, 1455-1465. (2008) (Pubitemid 351936310)
37. De Boer J, Siddappa R, Gaspar C, van Apeldoorn A, Fodde R, Van Blitterswijk C: Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 34, 818-826. (2004) (Pubitemid 38581127)
38. Etheridge SL, Spencer GJ, Heath DJ, Genever PG: Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells. Stem Cells 22, 849-860. (2004) (Pubitemid 39166941)
39. Samarzija I, Sini P, Schlange T, Macdonald G, Hynes NE: WNT3A regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways. Biochem Biophys Res Commun 386, 449-454. (2009)
40. Endo Y, Wolf V, Muraiso K, Kamijo K, Soon L, Uren A, Barshishat- Küpper M, Rubin JS: Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2. J Biol Chem 280, 777-786. (2005) (Pubitemid 40165046)
41. Tu X, Joeng KS, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, McMahon AP, Long F: Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell 12, 113-127. (2007) (Pubitemid 46002598)
42. Taschner MJ, Rafigh M, Lampert F, Schnaiter S, Hartmann C: Ca2+/Calmodulin-dependent kinase II signaling causes skeletal overgrowth and premature chondrocyte maturation. Dev Biol 317, 132-146. (2008)
43. Endo Y, Beauchamp E, Woods D, Taylor WG, Toretsky JA, Uren A, Rubin JS: Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol Cell Biol 28, 2368-2379. (2008) (Pubitemid 351429982)
44. Da Forno PD, Pringle JH, Hutchinson P, Osborn J, Huang Q, Potter L: WNT5A expression increases during melanoma progression and correlates with outcome. Clin Cancer Res 14, 5825-5832. (2008)
45. Yamamoto H, Oue N, Sato A, Hasegawa Y, Yamamoto H, Matsubara A: WNT5A signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase. Oncogene 29, 2036-2046. (2010)
46. Boland GM, Perkins G, Hall DJ, Tuan RS: Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cell Biochem 93, 1210-1230. (2004) (Pubitemid 44264134)
47. Baksh D, Boland GM, and Tuan RS: Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. J Cell Biochem 101, 1109-1124. (2007) (Pubitemid 47253714)
48. Mason JM, Grande DA, Barcia M, Grant R, Pergolizzi RG, and Breitbart AS: Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells: potential utility in gene therapy for osteochondral repair. Gene Ther 5, 1098-1104. (1998) (Pubitemid 28401312)
49. Gelse K, von der Mark K, Aigner T, Park J, and Schneider H: Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells. Arthritis Rheum 48, 430-441. (2003) (Pubitemid 36278012)