An in vivo drug screening model using glucose-6-phosphate dehydrogenase deficient mice to predict the hemolytic toxicity of 8-aminoquinolines

American Journal of Tropical Medicine and Hygiene

Volumn 88, Issue 6, 2013, Pages 1138-1145

  Zhang, Peng ^a   Gao, Xiugong ^a   Ishida, Hiroshi ^a   Amnuaysirikul, Jack ^a   Weina, Peter J ^a   Grogl, Max ^a   O'Neil, Michael T ^a   Li, Qigui ^a   Caridha, Diana ^a   Ohrt, Colin ^a   Hickman, Mark ^a   Magill, Alan J ^a   Ray, Prabhati ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; MEFLOQUINE; PAMAQUINE; PRIMAQUINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL COUNT; BLOOD TOXICITY; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVITY; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HEMOLYSIS; HEMOLYTIC ANEMIA; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHENOTYPE; RETICULOCYTE COUNT;

ACUTE DISEASE; AMINOQUINOLINES; ANEMIA, HEMOLYTIC; ANIMALS; ANTIMALARIALS; CHLOROQUINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GENOTYPE; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; GLUTATHIONE; HAPTOGLOBINS; HEMOLYTIC AGENTS; MALE; MEFLOQUINE; MICE; PHENOTYPE; PRIMAQUINE; RETICULOCYTE COUNT;

ANIMALIA; MUS;

EID: 84878771232     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.12-0682     Document Type: Article

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