Clinical significance of RUNX2 expression in patients with nonsmall cell lung cancer: A 5-year follow-up study

Tumor Biology

Volumn 34, Issue 3, 2013, Pages 1807-1812

  Li, Hong ^a   Zhou, Ren Jie ^a   Zhang, Guo Qiang ^a   Xu, Jian Ping ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

NSCLC; Prognosis; RUNX2

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR RUNX2;

ADULT; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CLINICAL EVALUATION; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MARKER GENE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RISK FACTOR; SURVIVAL TIME; TRANSCRIPTION FACTOR RUNX2 GENE; TUMOR VOLUME; WESTERN BLOTTING;

EID: 84878727196     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-0720-4     Document Type: Article

References (25)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90. doi: 10.3322/caac.20107.
2. Soria JC, Kim ES, Fayette J, Lantuejoul S, Deutsch E, Hong WK. Chemoprevention of lung cancer. Lancet Oncol. 2003;4:659-69.
3. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300. doi: 10.3322/caac.20073.
4. Chimge NO, Baniwal SK, Little GH, Chen YB, Kahn M, Tripathy D, et al. Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2. Breast Cancer Res. 2011;13(6):R127. doi: 10.1186/bcr3073.
5. Slattery ML, Lundgreen A, Herrick JS, Caan BJ, Potter JD, Wolff RK. Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and risk of colon and rectal cancer: additional support for a TGF-β-signaling pathway. Carcinogenesis. 2011;32(3):318-26. doi: 10.1093/carcin/bgq245.
6. Little GH, Noushmehr H, Baniwal SK, Berman BP, Coetzee GA, Frenkel B. Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40:3538-47. doi: 10.1093/nar/gkr1219.
7. Martin JW, Zielenska M, Stein GS, van Wijnen AJ, Squire JA. The role of RUNX2 in osteosarcoma oncogenesis. Sarcoma. 2011;2011:282745. doi: 10.1155/2011/282745.
8. van der Deen M, Akech J, Lapointe D, Gupta S, Young DW, Montecino MA, et al. Genomic promoter occupancy of runt-related transcription factor RUNX2 in osteosarcoma cells identifies genes involved in cell adhesion and motility. J Biol Chem. 2012;287:4503-17. doi: 10.1074/jbc.M111.287771.
9. Chua CW, Chiu YT, Yuen HF, Chan KW, Man K, Wang X, et al. Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform. Clin Cancer Res. 2009;15:4322-35. doi: 10.1158/1078-0432.CCR-08-3157.
10. Pratap J, Javed A, Languino LR, van Wijnen AJ, Stein JL, Stein GS, et al. The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol. 2005;25:8581-91.
11. Kayed H, Jiang X, Keleg S, Jesnowski R, Giese T, Berger MR, et al. Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancer. Br J Cancer. 2007;97:1106-15. doi: 10.1038/sj.bjc.6603984.
12. Sase T, Suzuki T, Miura K, Shiiba K, Sato I, Nakamura Y, et al. Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor. Int J Cancer. 2012;131:2284-93. doi: 10.1002/ijc.27525.
13. Dalle Carbonare L, Frigo A, Francia G, Davì MV, Donatelli L, Stranieri C, et al. Runx2 mRNA expression in the tissue, serum, and circulating non-hematopoietic cells of patients with thyroid cancer. J Clin Endocrinol Metab. 2012;97:E1249-56. doi: 10.1210/jc.2011-2624.
14. Tandon M, Gokul K, Ali SA, Chen Z, Lian J, Stein GS, et al. Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells. Mol Cancer. 2012;11:27. doi: 10.1186/1476-4598-11-27.
15. Li W, Yu CP, Xia JT, Zhang L, Weng GX, Zheng HQ, et al. Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. Clin Cancer Res. 2009;15:1393-9. doi: 10.1158/1078-0432.CCR-08-1158.
16. Remmele W, Stegner HE. Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe. 1987;8:138-40.
17. Blyth K, Vaillant F, Jenkins A, McDonald L, Pringle MA, Huser C, et al. Runx2 in normal tissues and cancer cells: a developing story. Blood Cells Mol Dis. 2010;45:117-23. doi: 10.1016/j.bcmd.2010.05.007.
18. Purcell DJ, Khalid O, Ou CY, Little GH, Frenkel B, Baniwal SK, et al. Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription. J Cell Biochem. 2012;113:2406-14. doi: 10.1002/jcb.24114.
19. Underwood KF, D'Souza DR, Mochin-Peters M, Pierce AD, Kommineni S, Choe M, et al. Regulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity. J Bone Miner Res. 2012;27:913-25. doi: 10.1002/jbmr.1504.
20. Lee KN, Jang WG, Kim EJ, Oh SH, Son HJ, Kim SH, et al. Orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) protein negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation through suppressing runt-related gene 2 (Runx2) activity. J Biol Chem. 2012;287:18888-99. doi: 10.1074/jbc.M111.311878.
21. Li Y, Ge C, Long JP, Begun DL, Rodriguez JA, Goldstein SA, et al. Biomechanical stimulation of osteoblast gene expression requires phosphorylation of the RUNX2 transcription factor. J Bone Miner Res. 2012;27:1263-74. doi: 10.1002/jbmr.1574.
22. Park ES, Lind AK, Dahm-Kähler P, Brännström M, Carletti MZ, Christenson LK, et al. RUNX2 transcription factor regulates gene expression in luteinizing granulosa cells of rat ovaries. Mol Endocrinol. 2010;24:846-58. doi: 10.1210/me.2009-0392.
23. Tonomoto Y, Tachibana M, Dhar DK, Onoda T, Hata K, Ohnuma H, et al. Differential expression of RUNX genes in human esophageal squamous cell carcinoma: downregulation of RUNX3 worsens patient prognosis. Oncology. 2007;73:346-56. doi: 10.1159/000135350.
24. Lee SH, Che X, Jeong JH, Choi JY, Lee YJ, Lee YH, et al. Runx2 protein stabilizes hypoxia-inducible factor-1α through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes. J Biol Chem. 2012;287:14760-71. doi: 10.1074/jbc.M112.340232.
25. Edvardsson K, Ström A, Jonsson P, Gustafsson JÅ, Williams C. Estrogen receptor β induces antiinflammatory and antitumorigenic networks in colon cancer cells. Mol Endocrinol. 2011;25:969-79. doi: 10.1210/me.2010- 0452.