Saliva sampling in global clinical studies: The impact of low sampling volume on performance of DNA in downstream genotyping experiments

BMC Medical Genomics

Volumn 6, Issue 1, 2013, Pages

  Pulford, David J ^a   Mosteller, Michael ^b   Briley, J David ^b   Johansson, Kelley W ^b   Nelsen, Anita J ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

DNA characteristics; Genotyping performance; Global study; Volume of saliva collection

Indexed keywords

GENOMIC DNA; DIAGNOSTIC KIT; DNA;

ARTICLE; CLINICAL RESEARCH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DETERMINATION; GENOTYPE; HUMAN; LABORATORY DEVICE; PERFORMANCE; PHARMACOGENETICS; PRIORITY JOURNAL; QUALITY CONTROL; SAFETY; SALIVA SAMPLING; SAMPLE SIZE; SAMPLING; SPECTROPHOTOMETER; TURBIDITY; BLOOD; COHORT ANALYSIS; DIAGNOSTIC KIT; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC PROCEDURES; ISOLATION AND PURIFICATION; METABOLISM; SALIVA; SINGLE NUCLEOTIDE POLYMORPHISM; STANDARDS;

COHORT STUDIES; DNA; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TECHNIQUES; GENOTYPE; HUMANS; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; REAGENT KITS, DIAGNOSTIC; SALIVA;

EID: 84878720371     PISSN: None     EISSN: 17558794     Source Type: Journal    
DOI: 10.1186/1755-8794-6-20     Document Type: Article

References (13)

1. Guidance for Industry Clinical Pharmacogenomics, Premarket evaluation in early-phase clinical studies and recommendations for labeling U.S. Department of Health and Human Services Food and Drug Administration 2013 http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/ Guidances/UCM337169.pdf
2. Current practices for DNA sample collection and storage in the pharmaceutical industry, and potential areas for harmonization: perspective of the I-PWG. Franc MA, Warner AW, Cohen N, Shaw PM, Groenen P, Snapir A, Clin Pharm Therap 2010 89 546 552
3. Collection of blood, saliva, and buccal cell samples in a pilot study on the Danish nurse cohort: comparison of the response rate and quality of genomic DNA. Hansen TO, Simonsen MK, Nielsen FC, Hundrup YA, Cancer Epidemiol Biomarkers Prev 2007 16 2072 2076 10.1158/1055-9965.EPI-07-0611 17932355 (Pubitemid 47621182)
4. Laboratory management of samples in biobanks: European consensus expert group report. Yuille M, Illig T, Hveem K, Schmitz G, Hansen J, Neumaier M, Tybring G, Wichmann E, Ollier B, Biopreserv Biobank 2010 8 65 69 10.1089/bio.2010.8102
5. Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping. Abraham JE, Maranian MJ, Spiteri I, Russell R, Ingle S, Luccarini C, Earl HM, Pharoah PD, Dunning AM, Caldas C, BMC Med Genomics 2012 5 19 10.1186/1755-8794-5-19 22647440
6. Genotyping performance between saliva and blood-derived genomic DNAs on the DMET array: a comparison. Hu Y, Ehli EA, Nelson K, Bohlen K, Lynch C, Huizenga P, Kittlelsrud J, Soundy TJ, Davies GE, PLoS One 2012 7 33968 10.1371/journal.pone.0033968 22448283
7. DNA probes using fluorescence resonance energy transfer (FRET): designs and applications. Didenko V V, Biotechniques 2001 31 1106 1116 11730017
8. National Institute of Dental and Craniofacial Research, NIH Publication No. 99-3174: Dry mouth National Oral Health Information Clearinghouse June 1999 http://dental.ufl.edu/files/2012/06/drymouth.pdf
9. Clinical trial participant characteristics and saliva and DNA metrics. Nishita DM, Jack LM, McElroy M, McClure JB, Richards J, Swan GE, Bergen AW, BMC Med. Res. Methodology 2009 9 71 10.1186/1471-2288-9-71
10. Beyond genomics. Dollery CT, Clin Pharmacol Ther 2007 82 366 370 10.1038/sj.clpt.6100363 17851575 (Pubitemid 47414367)
11. HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer. Spraggs CF, Budde LR, Briley LR, Bing N, Cox CJ, King KS, Whittaker JC, Mooser VE, Preston AJ, Stein SH, Cardon LR, J Clin Oncol 2011 29 667 673 10.1200/JCO.2010.31.3197 21245432
12. Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. Xu CF, Reck BH, Xue Z, Huang L, Baker KL, Chen M, Chen EP, Ellens HE, Mooser VE, Cardon LR, Spraggs CF, Pandite L, Br J Cancer 2010 102 1371 1377 10.1038/sj.bjc.6605653 20389299
13. nd edition. Sreenby LM, Schwartz SS, Gerodontology 1997 14 33 47 10.1111/j.1741-2358.1997.00033.x 9610301