Brief report: Altered social behavior in isolation-reared Fmr1 knockout mice

Journal of Autism and Developmental Disorders

Volumn 43, Issue 6, 2013, Pages 1452-1458

  Heitzer, Andrew M ^a   Roth, Alexandra K ^a,b   Nawrocki, Lauren ^a,c   Wrenn, Craige C ^a   Valdovinos, Maria G ^a  

^a DRAKE UNIVERSITY   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c DES MOINES UNIVERSITY   (United States)

Author keywords

fmr1 knockout mouse; Fragile X syndrome; Social behavior

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; FMR1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FRAGILE X SYNDROME; GENOTYPE; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PROTEIN ISOLATION; SNIFFING; SOCIAL BEHAVIOR; SOCIAL INTERACTION; WILD TYPE; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; DISEASE MODEL; GENETICS; PHYSIOLOGY; REPRODUCIBILITY; SOCIAL ISOLATION;

ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REPRODUCIBILITY OF RESULTS; SOCIAL BEHAVIOR; SOCIAL ISOLATION;

EID: 84878716374     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-012-1670-1     Document Type: Article

References (26)

1. Bassell, G. J.; & Warren, S. T. (2008). Fragile X syndrome: Loss of local mRNA regulation alters synaptic development and function. Neuron, 60(2), 201-214.
2. Brodkin, E. S. (2008). Social behavior phenotypes in Fragile X syndrome, autism, and the Fmr1 knockout mouse: Theoretical comment on McNaughton et al. (2008). Behavioral Neuroscience, 122(2), 483-489.
3. Cohen, D.; Pichard, N.; Tordjman, S.; Baumann, C.; Burglen, L.; Excoffier, E.; et al. (2005). Specific genetic disorders and autism: Clinical contribution towards their identification. Journal of Autism and Developmental Disorders, 35(1), 103-116.
4. Dahlhaus, R.; & El-Husseini, A. (2009). Altered neuroligin expression is involved in social deficits in a mouse model of the Fragile X syndrome. Behavioural Brain Research, 208(1), 96-105.
5. Demark, J. L.; Feldman, M. A.; & Holden, J. J. A. (2003). Behavioral relationship between autism and Fragile X syndrome. American Journal on Mental Retardation, 108(5), 314-326 + 363.
6. Feyder, M.; Karlsson, R.; Mathur, P.; Lyman, M.; Bock, R.; Momenan, R.; et al. (2010). Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome. American Journal of Psychiatry, 167(12), 1508-1517.
7. Hagerman, R. J.; & Hagerman, P. J. (2002). The Fragile X premutation: Into the phenotypic fold. Current Opinion in Genetics & Development, 12(3), 278-283.
8. Hatton, D. D.; Sideris, J.; Skinner, M.; Mankowski, J.; Bailey, D. B.; Jr, Roberts, J.; et al. (2006). Autistic behavior in children with Fragile X syndrome: Prevalence, stability, and the impact of FMRP. American Journal of Medical Genetics, Part A, 140(17), 1804-1813.
9. Ibi, D.; Takuma, K.; Koike, H.; Mizoguchi, H.; Tsuritani, K.; Kuwahara, Y.; et al. (2008). Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. Journal of Neurochemistry, 105(3), 921-932.
10. Kercmar, J.; Büdefeld, T.; Grgurevic, N.; Tobet, S. A.; & Majdic, G. (2011). Research report: Adolescent social isolation changes social recognition in adult mice. Behavioural Brain Research, 216, 647-651.
11. Koike, H.; Ibi, D.; Mizoguchi, H.; Nagai, T.; Nitta, A.; Takuma, K.; et al. (2009). Research report: Behavioral abnormality and pharmacologic response in social isolation-reared mice. Behavioural Brain Research, 202, 114-121.
12. Liu, Z.; & Smith, C. B. (2009). Dissociation of social and nonsocial anxiety in a mouse model of Fragile X syndrome. Neuroscience Letters, 454(1), 62-66.
13. McKinney, B. C.; Grossman, A. W.; Elisseou, N. M.; & Greenough, W. T. (2005). Dendritic spine abnormalities in the occipital cortex of C57BL/6 Fmr1 knockout mice. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics, 136B, 98-102.
14. McNaughton, C. H.; Moon, J.; Strawderman, M. S.; Maclean, K. N.; Evans, J.; & Strupp, B. J. (2008). Evidence for social anxiety and impaired social cognition in a mouse model of Fragile X syndrome. Behavioral Neuroscience, 122(2), 293-300.
15. Mines, M. A.; Yuskaitis, C. J.; King, M. K.; Beurel, E.; & Jope, R. S. (2010). GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of Fragile X syndrome and autism. PLoS ONE, 5(3), e9706.
16. Mineur, Y. S.; Huynh, L. X.; & Crusio, W. E. (2006). Social behavior deficits in the Fmr1 mutant mouse. Behavioural Brain Research, 168(1), 172-175.
17. Mineur, Y. S.; Sluyter, F.; De Wit, S.; Oostra, B. A.; & Crusio, W. E. (2002). Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse. Hippocampus, 12(1), 39-46.
18. Moy, S. S.; Nadler, J. J.; Perez, A.; Barbaro, R. P.; Johns, J. M.; Magnuson, T. R.; et al. (2004). Sociability and preference for social novelty in five inbred strains: An approach to assess autistic-like behavior in mice. Genes, Brain and Behavior, 3, 287-302.
19. Moy, S. S.; Nadler, J. J.; Young, N. B.; Nonneman, R. J.; Grossman, A. W.; Murphy, D. L.; et al. (2009). Social approach in genetically engineered mouse lines relevant to autism. Genes, Brain and Behavior, 8(2), 129-142.
20. Nadler, J. J.; Moy, S. S.; Dold, G.; Trang, D.; Simmons, N.; Perez, A.; et al. (2004). Automated apparatus for quantitation of social approach behaviors in mice. Genes, Brain and Behavior, 3(5), 303-314.
21. Pearson, B. L.; Defensor, E. B.; Blanchard, D. C.; & Blanchard, R. J. (2010). Research report: C57BL/6J mice fail to exhibit preference for social novelty in the three-chamber apparatus. Behavioural Brain Research, 213, 189-194.
22. Pieretti, M.; Zhang, F.; Fu, Y.; Warren, S. T.; Oostra, B. A.; Caskey, C. T.; et al. (1991). Absence of expression of the FMR-1 gene in fragile X syndrome. Cell, 66(4), 817-822.
23. Spencer, C. M.; Alekseyenko, O.; Serysheva, E.; Yuva-Paylor, L. A.; & Paylor, R. (2005). Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of Fragile X syndrome. Genes, Brain and Behavior, 4(7), 420-430.
24. Spencer, C. M.; Graham, D. F.; Yuva-Paylor, L. A.; Nelson, D. L.; & Paylor, R. (2008). Social behavior in Fmr1 knockout mice carrying a human FMR1 transgene. Behavioral Neuroscience, 122(3), 710-715.
25. Symons, F. J.; Byiers, B. J.; Raspa, M.; Bishop, E.; & Bailey, D. B.; Jr. (2010). Self-injurious behavior and Fragile X syndrome: Findings from the national Fragile X survey. American Journal on Intellectual and Developmental Disabilities, 115(6), 473-481.
26. Ventura, R.; Pascucci, T.; Catania, M.; Musumeci, S.; & Puglisi-Allegra, S. (2004). Object recognition impairment in Fmr1 knockout mice is reversed by amphetamine: Involvement of dopamine in the medial prefrontal cortex. Behavioural Pharmacology, 15(5-6), 433-442.