Overexpression of TNF in mitochondrial diseases caused by mutations in mtDNA: Evidence for signaling through its receptors on mitochondria

Free Radical Biology and Medicine

Volumn 63, Issue , 2013, Pages 108-114

  Vattemi, Gaetano ^a   Marini, Matte ^a   Ferreri, Nicholas R ^b   Hao, Shouji ^b   Malatesta, Manuela ^c   Meneguzzi, Alessandr ^d   Guglielmi, Valeri ^a   Fava, Cristian ^d   Minuz, Pietro ^d   Tomelleri, Giulian ^a  

^a Section of Clinical Neurology   (Italy)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c Dept of Morphol Biomed Sciences   (Italy)

^d UNIVERSITY OF VERONA   (Italy)

Author keywords

Freeradicals; Mitochondria; Mitochondrial diseases; TNF receptortype1; TNF receptortype2; Tumor necrosisfactor

Indexed keywords

MESSENGER RNA; MITOCHONDRIAL DNA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; CYTOCHROME C OXIDASE; FREE RADICAL; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE;

ADULT; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; HUMAN TISSUE; MITOCHONDRIAL ENCEPHALOMYOPATHY; MUSCLE BIOPSY; MUSCLE CELL; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; BIOPSY; CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA; COX; FEMALE; GENE EXPRESSION; GENETICS; MALE; MD; MELAS SYNDROME; MERRF SYNDROME; METABOLISM; MITOCHONDRION; MUTATION; OXPHOS; QRT-PCR; QUANTITATIVE REAL-TIME PCR; ROS; TNF RECEPTOR TYPE 1; TNF RECEPTOR TYPE 2; TNF-Α; TNFR1; TNFR2; TUMOR NECROSIS FACTOR-Α;

CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA; COX; CPEO; CYTOCHROME C OXIDASE; FREE RADICALS; MD; MELAS; MERRF; MITOCHONDRIA; MITOCHONDRIAL DISEASE; MITOCHONDRIAL DISEASES; MITOCHONDRIAL ENCEPHALOMYOPATHY WITH LACTIC ACIDOSIS AND STROKE-LIKE EPISODES; MYOCLONIC EPILEPSY WITH RAGGED RED FIBERS; OXIDATIVE PHOSPHORYLATION; OXPHOS; QRT-PCR; QUANTITATIVE REAL-TIME PCR; REACTIVE OXYGEN SPECIES; ROS; SDH; SUCCINATE DEHYDROGENASE; TNF RECEPTOR TYPE 1; TNF RECEPTOR TYPE 2; TNF-Α; TNFR1; TNFR2; TUMOR NECROSIS FACTOR-Α;

BIOPSY; DNA, MITOCHONDRIAL; FEMALE; GENE EXPRESSION; HUMANS; MALE; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MUTATION; OXIDATIVE PHOSPHORYLATION; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84878691621     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.04.025     Document Type: Article

References (29)

1. Zeviani, M.; Di Donato, S. Mitochondrial disorders. Brain 127:2153-2172; 2004. (Pubitemid 39382225)
2. DiMauro, S.; Schon, E. A. Mitochondrial respiratory-chain diseases. N. Engl. J. Med. 348:2656-2668; 2003. (Pubitemid 36741594)
3. McKenzie, M.; Liolitsa, D.; Hanna, M. Mitochondrial disease: mutations and mechanisms. Neurochem. Res. 29:589-600; 2004. (Pubitemid 38295009)
4. Wajant, H.; Pfizenmaier, K.; Scheurich, P. Tumor necrosis factor signaling. Cell Death Differ. 10:45-65; 2003. (Pubitemid 36511832)
5. James, A.; Murphy, M. How mitochondrial damage affects cell function. J. Biomed. Sci. 9:475-487; 2002. (Pubitemid 35316860)
6. Vassalli, P. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10:411-452; 1992.
7. Tartaglia, L. A.; Weber, R. F.; Figari, I. S., et al. The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc. Natl. Acad. Sci. USA 88:9292-9296; 1991. (Pubitemid 21915617)
8. Manna, S. K.; Zhang, H. J.; Yan, T., et al. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-?B and activated protein-1. J. Biol. Chem 273:13245-13254; 1998. (Pubitemid 28246897)
9. Manna, S. K.; Kuo, M. T.; Aggarwal, B. B. Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apop-tosis and activation of nuclear transcription factor-kappa B and activator protein-1. Oncogene 18:4371-4382; 1999. (Pubitemid 29392378)
10. Busquets, S. L.; Aranda, X.; Ribas-Carbó, M., et al. Tumour necrosis factor-alpha uncouples respiration in isolated rat mitochondria. Cytokine 22:1-4; 2003. (Pubitemid 37222296)
11. Lancaster Jr J. R.; Laster, S. M.; Gooding, L. R. Inhibition of target cell mito-chondrial electron transfer by tumor necrosis factor. FEBS Lett. 248:169-174; 1989. (Pubitemid 19129336)
12. Jääskeläinen, M.; Nieminen, A.; Pökkylä, R. M., et al. Regulation of cell death in human fetal and adult ovaries-role of Bok and Bcl-XL. Mol. Cell. Endocrinol. 330:17-24; 2010.
13. Luce, A.; Courtin, A.; Levalois, C., et al. Death receptor pathways mediate targeted and non-targeted effects of ionizing radiations in breast cancer cells. Carcinogenesis 30:432-439; 2009.
14. Harry, G. J.; Lefebvre d'Hellencourt, C.; McPherson, C. A., et al. Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apoptosis of dentate granule neurons. J. Neurochem 106:281-298; 2008. (Pubitemid 351840211)
15. Li, Y. P.; Schwartz, R. J. TNF-a regulates early differentiation of C2C12 myoblasts in an autocrine fashion. FASEB J 15:1413-1415; 2001.
16. Keller, C.; Hellsten, Y.; Steensberg, A., et al. Differential regulation of IL-6 and TNF-a via calcineurin in human skeletal muscle cells. Cytokine 36:141-147; 2006.
17. Lindberg, C.; Oldfors, A. Local T-cell proliferation and differentiation in inflammatory myopathies. Scand. J. Immunol. 41:421-426; 1995.
18. Tews, D.; Goebel, H. Cytokine expression profile in idiopathic inflammatory myopathies. J. Neuropathol. Exp. Neurol. 55:342-347; 1996. (Pubitemid 26085583)
19. Kuru, S.; Inukai, A.; Kato, T., et al. Expression of tumor necrosis factor-a in regenerating muscle fibers in inflammatory and non-inflammatory myopa-thies. Acta Neuropathol. (Berlin 105:217-224; 2003. (Pubitemid 36798812)
20. Bradley, J. R. TNF-mediated inflammatory disease. J. Pathol. 214:149-160; 2008. (Pubitemid 351160153)
21. Torre-Amione, G.; Kapadia, S.; Lee, J., et al. Expression and functional significance of tumor necrosis factor receptors in human myocardium. Circulation 92:1487-1493; 1995.
22. Al-Lamki, R. S.; Brookes, A. P.; Wang, J., et al. TNF receptors differentially signal and are differentially expressed and regulated in the human heart. Am. J. Transplant. 9:2679-2696; 2009.
23. Dirks, A. J.; Leeuwenburgh, C. Tumor necrosis factor a signaling in skeletal muscle: effects of age and caloric restriction. J. Nutr. Biochem. 17: 501-508; 2006. (Pubitemid 44102706)
24. Plomgaard, P.; Bouzakri, K.; Krogh-Madsen, R., et al. Tumor necrosis factor-a induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes 54:2939-2945; 2005. (Pubitemid 41401090)
25. Saghizadeh, M.; Ong, J. M.; Garvey, W. T., et al. The expression of TNF alpha by human muscle: relationship to insulin resistance. J. Clin. Invest. 97:1111-1116; 1996. (Pubitemid 26070591)
26. De Bleecker, J. L.; Meire, V. I.; Declercq, W., et al. Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies. Neuro-muscul. Disord 9:239-246; 1999. (Pubitemid 29287259)
27. Ledgerwood, E. C.; Prins, J. B.; Bright, N. A., et al. Tumor necrosis factor is delivered to mitochondria where a tumor necrosis factor-binding protein is localized. Lab. Invest. 78:1583-1589; 1998. (Pubitemid 29022234)
28. Lacerda, L.; McCarthy, J.; Mungly, S., et al. TNFa protects cardiac mitochondria independently of its cell surface receptors. Basic Res. Cardiol. 105:751-762; 2010.
29. Bernardi, P.; Krauskopf, A.; Basso, E., et al. The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J. 273:2077-2099; 2006.